Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Cell Death and Differentiation, Journal Year: 2018, Volume and Issue: 25(3), P. 486 - 541

Published: Jan. 23, 2018

Over the past decade, Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for definition and interpretation of cell death from morphological, biochemical, functional perspectives. Since field continues to expand novel mechanisms that orchestrate multiple pathways are unveiled, we propose an updated classification subroutines focusing mechanistic essential (as opposed correlative dispensable) aspects process. As provide molecularly oriented definitions terms including intrinsic apoptosis, extrinsic mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic death, NETotic lysosome-dependent autophagy-dependent immunogenic cellular senescence, mitotic catastrophe, discuss utility neologisms refer highly specialized instances these processes. The mission NCCD is a widely accepted nomenclature in support continued development field.

Language: Английский

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Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

Nature Reviews Drug Discovery, Journal Year: 2019, Volume and Issue: 18(3), P. 197 - 218

Published: Jan. 4, 2019

Language: Английский

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Immunogenic cell death in cancer and infectious disease

Nature reviews. Immunology, Journal Year: 2016, Volume and Issue: 17(2), P. 97 - 111

Published: Oct. 17, 2016

Language: Английский

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Dendritic cells in cancer immunology and immunotherapy

Nature reviews. Immunology, Journal Year: 2019, Volume and Issue: 20(1), P. 7 - 24

Published: Aug. 29, 2019

Language: Английский

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Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

Nature Immunology, Journal Year: 2016, Volume and Issue: 17(10), P. 1142 - 1149

Published: Sept. 20, 2016

Language: Английский

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Inflammation and tumor progression: signaling pathways and targeted intervention

Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)

Published: July 12, 2021

Abstract Cancer development and its response to therapy are regulated by inflammation, which either promotes or suppresses tumor progression, potentially displaying opposing effects on therapeutic outcomes. Chronic inflammation facilitates progression treatment resistance, whereas induction of acute inflammatory reactions often stimulates the maturation dendritic cells (DCs) antigen presentation, leading anti-tumor immune responses. In addition, multiple signaling pathways, such as nuclear factor kappa B (NF-kB), Janus kinase/signal transducers activators transcription (JAK-STAT), toll-like receptor (TLR) cGAS/STING, mitogen-activated protein kinase (MAPK); factors, including cytokines (e.g., interleukin (IL), interferon (IFN), necrosis (TNF)-α), chemokines C-C motif chemokine ligands (CCLs) C-X-C (CXCLs)), growth factors vascular endothelial (VEGF), transforming (TGF)-β), inflammasome; well metabolites prostaglandins, leukotrienes, thromboxane, specialized proresolving mediators (SPM), have been identified pivotal regulators initiation resolution inflammation. Nowadays, local irradiation, recombinant cytokines, neutralizing antibodies, small-molecule inhibitors, DC vaccines, oncolytic viruses, TLR agonists, SPM developed specifically modulate in cancer therapy, with some these already undergoing clinical trials. Herein, we discuss crosstalk between processes. We also highlight potential targets for harnessing cancer.

Language: Английский

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DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity

Nature Communications, Journal Year: 2017, Volume and Issue: 8(1)

Published: June 9, 2017

Abstract Radiotherapy is under investigation for its ability to enhance responses immunotherapy. However, the mechanisms by which radiation induces anti-tumour T cells remain unclear. We show that DNA exonuclease Trex1 induced doses above 12–18 Gy in different cancer cells, and attenuates their immunogenicity degrading accumulates cytosol upon radiation. Cytosolic stimulates secretion of interferon-β following activation sensor cGAS downstream effector STING. Repeated irradiation at do not induce amplifies production, resulting recruitment Batf3-dependent dendritic cells. This effect essential priming CD8 + mediate systemic tumour rejection (abscopal effect) context immune checkpoint blockade. Thus, an upstream regulator radiation-driven immunity. induction may guide selection dose fractionation patients treated with

Language: Английский

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The cGAS–STING pathway as a therapeutic target in inflammatory diseases

Nature reviews. Immunology, Journal Year: 2021, Volume and Issue: 21(9), P. 548 - 569

Published: April 8, 2021

Language: Английский

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Molecular mechanisms and cellular functions of cGAS–STING signalling

Nature Reviews Molecular Cell Biology, Journal Year: 2020, Volume and Issue: 21(9), P. 501 - 521

Published: May 18, 2020

Language: Английский

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CD4+ T cell help in cancer immunology and immunotherapy

Nature reviews. Immunology, Journal Year: 2018, Volume and Issue: 18(10), P. 635 - 647

Published: July 29, 2018

Language: Английский

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