Innate Lymphoid Cells: 10 Years On

Cell, Journal Year: 2018, Volume and Issue: 174(5), P. 1054 - 1066

Published: Aug. 1, 2018

Language: Английский

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Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

Journal of Clinical Investigation, Journal Year: 2018, Volume and Issue: 128(7), P. 2657 - 2669

Published: May 13, 2018

Countless times each day, the acute inflammatory response protects us from invading microbes, injuries, and insults within, as in surgery-induced tissue injury. These challenges go unnoticed because they are self-limited naturally resolve without progressing to chronic inflammation. Peripheral blood markers of inflammation present many common diseases, including bowel disease, cardiovascular neurodegenerative cancer. While is protective, excessive swarming neutrophils amplifies collateral damage Hence, understanding mechanisms that control resolution provides insight into preventing treating diseases multiple organs. This Review focuses on phase with identification specialized pro-resolving mediators (SPMs) involve three separate biosynthetic potent mediator families, which defined using first quantitative indices score this vital process. resolvins, protectins, maresins: bioactive metabolomes stimulate innate responses, enhance microbial killing clearance, organ-protective. We briefly address biosynthesis SPMs their activation endogenous programs terrain for new therapeutic approaches not, by definition, immunosuppressive, but rather immunoresolvent therapies.

Language: Английский

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Advances in the understanding and treatment of sepsis-induced immunosuppression

Nature Reviews Nephrology, Journal Year: 2017, Volume and Issue: 14(2), P. 121 - 137

Published: Dec. 11, 2017

Language: Английский

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Mechanisms and Therapeutic Relevance of Neuro-immune Communication

Immunity, Journal Year: 2017, Volume and Issue: 46(6), P. 927 - 942

Published: June 1, 2017

Language: Английский

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Molecular and Functional Neuroscience in Immunity

Annual Review of Immunology, Journal Year: 2018, Volume and Issue: 36(1), P. 783 - 812

Published: April 20, 2018

The nervous system regulates immunity and inflammation. molecular detection of pathogen fragments, cytokines, other immune molecules by sensory neurons generates immunoregulatory responses through efferent autonomic neuron signaling. functional organization this neural control is based on principles reflex regulation. Reflexes involving the vagus nerve nerves have been therapeutically explored in models inflammatory autoimmune conditions, recently clinical settings. brain integrates neuro-immune communication, function altered diseases characterized peripheral dysregulation Here we review anatomical basis interface with immunity, focusing functions role model immunological homunculus. Clinical advances stemming from knowledge within framework bioelectronic medicine are also briefly outlined.

Language: Английский

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Innate Lymphoid Cells: Diversity, Plasticity, and Unique Functions in Immunity

Immunity, Journal Year: 2018, Volume and Issue: 48(6), P. 1104 - 1117

Published: June 1, 2018

Language: Английский

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Innate lymphoid cells: major players in inflammatory diseases

Nature reviews. Immunology, Journal Year: 2017, Volume and Issue: 17(11), P. 665 - 678

Published: Aug. 14, 2017

Language: Английский

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Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors

Molecular Aspects of Medicine, Journal Year: 2017, Volume and Issue: 58, P. 114 - 129

Published: March 31, 2017

Language: Английский

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Resolution of inflammation: An organizing principle in biology and medicine

Pharmacology & Therapeutics, Journal Year: 2021, Volume and Issue: 227, P. 107879 - 107879

Published: April 27, 2021

Language: Английский

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Discovery of specialized pro-resolving mediators marks the dawn of resolution physiology and pharmacology

Molecular Aspects of Medicine, Journal Year: 2017, Volume and Issue: 58, P. 1 - 11

Published: March 3, 2017

Language: Английский

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