Shared inflammatory glial cell signature after stab wound injury, revealed by spatial, temporal, and cell-type-specific profiling of the murine cerebral cortex DOI Creative Commons
Christina Koupourtidou, Veronika Schwarz, Hananeh Aliee

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 3, 2024

Traumatic brain injury leads to a highly orchestrated immune- and glial cell response partially responsible for long-lasting disability the development of secondary neurodegenerative diseases. A holistic understanding mechanisms controlling responses specific types their crosstalk is required develop an efficient strategy better regeneration. Here, we combine spatial single-cell transcriptomics chart transcriptomic signature injured male murine cerebral cortex, identify states different cells contributing this signature. Interestingly, distinct share large fraction injury-regulated genes, including inflammatory programs downstream innate immune-associated pathways Cxcr3 Tlr1/2. Systemic manipulation these decreases reactivity state associated with poor The functional relevance discovered shared highlights importance our resource enabling comprehensive analysis early events after injury.

Language: Английский

Beyond the neuron: Role of non-neuronal cells in stress disorders DOI Creative Commons
Flurin Cathomas, Leanne M. Holt, Eric M. Parise

et al.

Neuron, Journal Year: 2022, Volume and Issue: 110(7), P. 1116 - 1138

Published: Feb. 18, 2022

Language: Английский

Citations

50
Role of lipocalin 2 in stroke DOI Creative Commons
Ruoyu Zhao,

Pengju Wei,

Xin Sun

et al.

Neurobiology of Disease, Journal Year: 2023, Volume and Issue: 179, P. 106044 - 106044

Published: Feb. 17, 2023

Stroke is the second leading cause of death worldwide; however, treatment choices available to neurologists are limited in clinical practice. Lipocalin 2 (LCN2) a secreted protein, belonging lipocalin superfamily, with multiple biological functions mediating innate immune response, inflammatory iron-homeostasis, cell migration and differentiation, energy metabolism, other processes body. LCN2 expressed at low levels brain under normal physiological conditions, but its expression significantly up-regulated acute stimulations chronic pathologies. An up-regulation has been found blood/cerebrospinal fluid patients ischemic/hemorrhagic stroke, could serve as potential biomarker for prediction severity stroke. activates reactive astrocytes microglia, promotes neutrophil infiltration, amplifies post-stroke inflammation, blood-brain barrier disruption, white matter injury, neuronal death. Moreover, involved injury induced by thrombin erythrocyte lysates, well microvascular thrombosis after hemorrhage. In this paper, we review role pathological ischemic stroke; intracerebral hemorrhage; subarachnoid stroke-related diseases, such vascular dementia depression, their underlying mechanisms. We hope that will help elucidate value therapeutic target

Language: Английский

Citations

36
Reactive Astrocytes and Emerging Roles in Central Nervous System (CNS) Disorders DOI
Shane A. Liddelow, Michelle L. Olsen, Michael V. Sofroniew

et al.

Cold Spring Harbor Perspectives in Biology, Journal Year: 2024, Volume and Issue: 16(7), P. a041356 - a041356

Published: Feb. 5, 2024

In addition to their many functions in the healthy central nervous system (CNS), astrocytes respond CNS damage and disease through a process called "reactivity." Recent evidence reveals that astrocyte reactivity is heterogeneous spectrum of potential changes occur context-specific manner. These are determined by diverse signaling events vary not only with nature severity different insults but also location CNS, genetic predispositions, age, potentially "molecular memory" previous events. Astrocyte can be associated both essential beneficial as well harmful effects. The available information rapidly expanding much has been learned about molecular diversity reactivity. Emerging functional associations point toward roles for determining outcome disorders.

Language: Английский

Citations

16
M2 Microglia-derived Exosomes Promote Spinal Cord Injury Recovery in Mice by Alleviating A1 Astrocyte Activation DOI
Jing Zhang, Die Hu, Liping Li

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(9), P. 7009 - 7025

Published: Feb. 17, 2024

Language: Английский

Citations

16
Shared inflammatory glial cell signature after stab wound injury, revealed by spatial, temporal, and cell-type-specific profiling of the murine cerebral cortex DOI Creative Commons
Christina Koupourtidou, Veronika Schwarz, Hananeh Aliee

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 3, 2024

Traumatic brain injury leads to a highly orchestrated immune- and glial cell response partially responsible for long-lasting disability the development of secondary neurodegenerative diseases. A holistic understanding mechanisms controlling responses specific types their crosstalk is required develop an efficient strategy better regeneration. Here, we combine spatial single-cell transcriptomics chart transcriptomic signature injured male murine cerebral cortex, identify states different cells contributing this signature. Interestingly, distinct share large fraction injury-regulated genes, including inflammatory programs downstream innate immune-associated pathways Cxcr3 Tlr1/2. Systemic manipulation these decreases reactivity state associated with poor The functional relevance discovered shared highlights importance our resource enabling comprehensive analysis early events after injury.

Language: Английский

Citations

15