Functional states of myeloid cells in cancer DOI Creative Commons

Lilian van Vlerken-Ysla,

Yulia Y. Tyurina, Valerian E. Kagan

et al.

Cancer Cell, Journal Year: 2023, Volume and Issue: 41(3), P. 490 - 504

Published: March 1, 2023

Language: Английский

Synovial tissue macrophages in joint homeostasis, rheumatoid arthritis and disease remission DOI
Mariola Kurowska‐Stolarska, Stefano Alivernini

Nature Reviews Rheumatology, Journal Year: 2022, Volume and Issue: 18(7), P. 384 - 397

Published: June 7, 2022

Language: Английский

Citations

129
NF-κB in monocytes and macrophages – an inflammatory master regulator in multitalented immune cells DOI Creative Commons
Marion Mußbacher, Martina Derler, José Basílio

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 23, 2023

Nuclear factor κB (NF-κB) is a dimeric transcription constituted by two of five protein family members. It plays an essential role in inflammation and immunity regulating the expression numerous chemokines, cytokines, factors, regulatory proteins. Since NF-κB expressed almost all human cells, it important to understand its cell type-, tissue-, stimulus-specific roles as well temporal dynamics disease-specific context. Although was discovered more than 35 years ago, many questions are still unanswered, with availability novel technologies such single-cell sequencing fate-mapping, new fascinating arose. In this review, we will summarize current findings on monocytes macrophages. These innate immune cells show high plasticity dynamically adjust their effector functions against invading pathogens environmental cues. Their versatile can range from antimicrobial defense antitumor responses foam formation wound healing. crucial for activation balances phenotypes finely coordinating transcriptional epigenomic programs. Thereby, critically involved inflammasome activation, cytokine release, survival. Macrophage-specific has far-reaching implications development progression inflammatory diseases. Moreover, recent highlighted myeloid underlined complexity master regulator. This review provide overview complex macrophage signal transduction, polarization,

Language: Английский

Citations

125
Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease DOI Creative Commons

Alba Garrido-Trigo,

A M Corraliza, Marisol Veny

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: July 26, 2023

Abstract Ulcerative colitis and Crohn’s disease are chronic inflammatory intestinal diseases with perplexing heterogeneity in manifestation response to treatment. While the molecular basis for this remains uncharacterized, single-cell technologies allow us explore transcriptional states within tissues at an unprecedented resolution which could further understanding of these complex diseases. Here, we apply RNA-sequencing human inflamed intestine show that largest differences among patients present myeloid compartment including macrophages neutrophils. Using spatial transcriptomics tissue (CosMx Spatial Molecular Imaging) spatially localize each macrophage neutrophil subsets identified by unravel diversity based on their localization. Finally, combined analysis reveals a strong communication network involving fibroblasts. Our data sheds light cellular complexity points towards stromal compartments as important patient-to-patient heterogeneity.

Language: Английский

Citations

117
Discovering dominant tumor immune archetypes in a pan-cancer census DOI Creative Commons
Alexis J. Combes, Bushra Samad, Jessica Tsui

et al.

Cell, Journal Year: 2021, Volume and Issue: 185(1), P. 184 - 203.e19

Published: Dec. 27, 2021

Language: Английский

Citations

115
Functional states of myeloid cells in cancer DOI Creative Commons

Lilian van Vlerken-Ysla,

Yulia Y. Tyurina, Valerian E. Kagan

et al.

Cancer Cell, Journal Year: 2023, Volume and Issue: 41(3), P. 490 - 504

Published: March 1, 2023

Language: Английский

Citations

114