Potential Anti-Rheumatoid Arthritis Activities and Mechanisms of Ganoderma lucidum Polysaccharides DOI Creative Commons
Meng Meng, Jialin Yao, Yukun Zhang

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(6), P. 2483 - 2483

Published: March 8, 2023

Rheumatoid arthritis (RA) is a chronic and autoimmune disease characterized by inflammation, dysfunction, cartilage bone destruction. In this review, we summarized the available reports on protective effects of Ganoderma lucidum polysaccharides (GLP) RA in terms anti-inflammatory, immunomodulatory, anti-angiogenic osteoprotective effects. Firstly, GLP inhibits synovial fibroblast (RASF) proliferation migration, modulates pro- anti-inflammatory cytokines reduces inflammation. Secondly, regulates differentiation antigen-presenting cells such as dendritic cells, phagocytosis mononuclear macrophages nature killer (NK) ratio M1, M2 related inflammatory cytokines. addition, produced activities balancing humoral cellular immunity, regulating immunoglobulin production, modulating T B lymphocyte proliferative responses cytokine release, exhibiting immunomodulatory Thirdly, angiogenesis through direct inhibition vascular endothelial cell induction death indirect growth factor (VEGF) production cells. Finally, can inhibit matrix metalloproteinases promote osteoblast formation, exerting articular cartilage. It suggested that may be promising agent for treatment RA.

Language: Английский

The pathogenesis of rheumatoid arthritis DOI Creative Commons
Stefano Alivernini, Gary S. Firestein, Iain B. McInnes

et al.

Immunity, Journal Year: 2022, Volume and Issue: 55(12), P. 2255 - 2270

Published: Dec. 1, 2022

Language: Английский

Citations

467
The Role of Viral Infections in the Onset of Autoimmune Diseases DOI Creative Commons
Bhargavi Sundaresan, Fatemeh Shirafkan, Kevin Ripperger

et al.

Viruses, Journal Year: 2023, Volume and Issue: 15(3), P. 782 - 782

Published: March 18, 2023

Autoimmune diseases (AIDs) are the consequence of a breach in immune tolerance, leading to inability sufficiently differentiate between self and non-self. Immune reactions that targeted towards self-antigens can ultimately lead destruction host’s cells development autoimmune diseases. Although disorders comparatively rare, worldwide incidence prevalence is increasing, they have major adverse implications for mortality morbidity. Genetic environmental factors thought be contributing autoimmunity. Viral infections one triggers Current research suggests several mechanisms, such as molecular mimicry, epitope spreading, bystander activation, cause viral-induced Here we describe latest insights into pathomechanisms discuss recent findings on COVID-19 AIDs.

Language: Английский

Citations

87
Harmonized cross-species cell atlases of trigeminal and dorsal root ganglia DOI Creative Commons
Shamsuddin A. Bhuiyan, Mengyi Xu,

Lite Yang

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(25)

Published: June 21, 2024

Sensory neurons in the dorsal root ganglion (DRG) and trigeminal (TG) are specialized to detect transduce diverse environmental stimuli central nervous system. Single-cell RNA sequencing has provided insights into diversity of sensory ganglia cell types rodents, nonhuman primates, humans, but it remains difficult compare across studies species. We thus constructed harmonized atlases DRG TG that describe facilitate comparison 18 neuronal 11 non-neuronal six species 31 datasets. then performed single-cell/nucleus from both human highly regenerative axolotl found atlas also improves type annotation, particularly sparse subtypes. observed transcriptomes neuron subtypes broadly similar vertebrates, expression functionally important neuropeptides channels can vary notably. The resources presented here guide future comparative transcriptomics, simplify cell-type nomenclature differences studies, help prioritize targets for analgesic development.

Language: Английский

Citations

43
T Cell Dysregulation in Rheumatoid Arthritis: from Genetic Susceptibility to Established Disease DOI Creative Commons

Athena Chin,

Annabelle Small, Soon Wei Wong

et al.

Current Rheumatology Reports, Journal Year: 2025, Volume and Issue: 27(1)

Published: Jan. 25, 2025

Abstract Purpose of Review Rheumatoid arthritis (RA) is a complex autoimmune disease characterized by chronic inflammation the synovial tissue, where T cells play central role in pathogenesis. Recent research has identified peripheral helper (Tph) as critical mediators local B cell activation inflamed tissues. This review synthesizes latest advancements our understanding RA, from initiation to established disease. Findings We explore recent advances regarding genetic and epigenetic factors that predispose individuals mechanisms differentiation, interactions between other immune stromal within microenvironment. The emergence Tph key drivers RA pathobiology highlighted, along with their potential therapeutic targets. also discuss heterogeneity responses interplay cells, while addressing gaps such recruitment plasticity phenotypes. Summary A deeper dynamics will provide valuable insights for developing targeted therapies modulate cell-mediated improve patient outcomes.

Language: Английский

Citations

2
Genetically predicted C-reactive protein mediates the association between rheumatoid arthritis and atlantoaxial subluxation DOI Creative Commons
Jiaqin Yuan,

Xiaoqin Xiong,

Bin Zhang

et al.

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: Dec. 16, 2022

Investigating the causal relationship between rheumatoid arthritis (RA) and atlantoaxial subluxation (AAS) identifying quantifying role of C-reactive protein (CRP) as a potential mediator.Using summary-level data from genome-wide association study (GWAS), two-sample Mendelian randomization (MR) analysis genetically predicted (14,361 cases, 43,923 controls) AAS (141 227,388 was performed. Furthermore, we used two-step MR to quantitate proportion effect c-reactive protein-mediated RA on AAS.MR identified higher (primary odds ratio (OR) 0.61/SD increase, 95% confidence interval (CI) 1.36-1.90) increased risk AAS. There no strong evidence that had an (OR 1.001, CI 0.97-1.03). The mediated by 3.7% (95%CI 0.1%-7.3%).In conclusion, our AAS, with small CRP, but majority remains unclear. Further research is needed additional factors mediators. In clinical practice, lesions upper cervical spine in patients need be given more attention.

Language: Английский

Citations

40
Oral Delivery of siRNA Using Fluorinated, Small‐Sized Nanocapsules toward Anti‐Inflammation Treatment DOI
Yuansong Wei,

Xudong Li,

Juanhui Lin

et al.

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(11)

Published: Dec. 27, 2022

Oral delivery of small interfering RNA (siRNA) provides a promising paradigm for treating diseases that require regular injections. However, the multiple gastrointestinal (GI) and systemic barriers often lead to inefficient oral absorption low bioavailability siRNA. Technologies can overcome these are still lacking, which hinders clinical potential orally delivered Herein, small-sized, fluorinated nanocapsules (F-NCs) developed mediate efficient tumor necrosis factor α (TNF-α) siRNA anti-inflammation treatment. The NCs possess disulfide-cross-linked shell structure, thus featuring robust stability in GI tract. Because their size (≈30 nm) fluorocarbon-assisted repelling mucin adsorption, best-performing F3 -NCs show excellent mucus penetration intestinal transport capabilities without impairing tight junction, conferring 20.4% relative intravenous injection. disulfide cross-linker be cleaved inside target cells, causing dissociation release potentiate TNF-α silencing efficiency. In murine models acute chronic inflammation, provoke pronounced anti-inflammatory efficacies. This study therefore transformative strategy delivery, will render utilities

Language: Английский

Citations

39
Bone/cartilage organoid on-chip: Construction strategy and application DOI Creative Commons
Yan Hu, Hao Zhang, Sicheng Wang

et al.

Bioactive Materials, Journal Year: 2023, Volume and Issue: 25, P. 29 - 41

Published: Jan. 20, 2023

The necessity of disease models for bone/cartilage related disorders is well-recognized, but the barrier between ex-vivo cell culture, animal and real human body has been pending decades. organoid-on-a-chip technique showed opportunity to revolutionize basic research drug screening diseases like osteoporosis arthritis. organoid on-chip (BCoC) system a novel platform multi-tissue which faithfully emulate essential elements, biologic functions pathophysiological response under circumstances. In this review, we propose concept BCoC platform, summarize modules current efforts orchestrate them on single microfluidic system. Current models, unsolved problems future challenging are also discussed, aim should be deeper understanding diseases, ultimate realization generic tools further therapeutic strategies pathological conditions.

Language: Английский

Citations

38
Development of a Nanohybrid Peptide Hydrogel for Enhanced Intervertebral Disc Repair and Regeneration DOI

Brian Conley,

Letao Yang,

Basanta Bhujel

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(4), P. 3750 - 3764

Published: Feb. 13, 2023

Effective therapeutic approaches to overcome the heterogeneous pro-inflammatory and inhibitory extracellular matrix (ECM) microenvironment are urgently needed achieve robust structural functional repair of severely wounded fibrocartilaginous tissues. Herein we developed a dynamic multifunctional nanohybrid peptide hydrogel (NHPH) through hierarchical self-assembly amphiphile modified with biodegradable two-dimensional nanomaterials enzyme-like functions. NHPH is not only injectable, biocompatible, but also by catalyzing scavenging reactive oxygen species promoting ECM remodeling. In addition, our method facilitated recovery intervertebral disc (IVD) after severe injuries delivering pro-regenerative cytokines in sustained manner, effectively suppressing immune responses eventually restoring regenerative ECM. parallel, NHPH-enhanced nucleus pulposus cell differentiation pain reduction rat nucleotomy model further validated potential NHPH. Collectively, advanced nanoscaffold technology will provide an alternative approach for effective treatment IVD degeneration as well other tissue injuries.

Language: Английский

Citations

36
A Targeted Exosome Therapeutic Confers Both CfDNA Scavenging and Macrophage Polarization for Ameliorating Rheumatoid Arthritis DOI Open Access
Zhe Wang, Chuanjie Zhang, Jiaqi Meng

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(48)

Published: Sept. 8, 2023

Only a minority of rheumatoid arthritis (RA) patients achieve disease remission, so the exploration additional pathogenic factors and development new therapeutics are needed. Here, strong correlations among cell-free DNA (cfDNA) level inflammatory response in clinical synovial fluid samples RA activity discovered. The important role cfDNA collagen-induced (CIA) murine model is also demonstrated. Building on these findings, novel therapeutic based anti-inflammatory (M2) macrophage-derived exosomes as chassis, that modified with both oligolysine matrix metalloproteinase (MMP)-cleavable polyethylene glycol (PEG) membrane, developed. After intravenous injection, PEG-enabled prolonged circulation C─C motif chemokine ligand-directed accumulation together result enrichment at inflamed joints. Following subsequent MMP cleavage, positively charged exposed for scavenging, while induce M2 polarization. By using classical CIA newly established canine model, it demonstrated rationally designed exosome substantially suppresses inflammation joints provides chondroprotection osteoprotection, revealing its potential effective amelioration.

Language: Английский

Citations

36
Peptide-anchored neutrophil membrane-coated biomimetic nanodrug for targeted treatment of rheumatoid arthritis DOI Creative Commons

Ni Yang,

Miaomiao Li,

Ling Wu

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Jan. 13, 2023

Macrophage polarization determines the production of cytokines that fuel initiation and evolution rheumatoid arthritis (RA). Thus, modulation macrophage might represent a potential therapeutic strategy for RA. However, coordinated macrophages in synovium synovial fluid has not been achieved thus far. Herein, we develop biomimetic ApoA-I mimetic peptide-modified neutrophil membrane-wrapped F127 polymer (R4F-NM@F127) targeted drug delivery during RA treatment. Due to high expression adhesion molecules chemokine receptors on neutrophils, membrane coating can endow nanocarrier with synovitis-targeting ability, subsequent recruitment under chemotactic effects IL-8. Moreover, R4F peptide modification further endows ability target SR-B1 receptor, which is highly expressed fluid. Long-term vivo imaging shows R4F-NM@F127 preferentially accumulates inflamed joints engulfed by macrophages. After loading anti-inflammatory celastrol (Cel), R4F-NM@F127-Cel significant reduction hepatotoxicity, effectively inhibits inflammation alleviates joint damage reprogramming polarization. our results highlight as promising option treatment

Language: Английский

Citations

31