Gut,
Journal Year:
2024,
Volume and Issue:
73(8), P. 1376 - 1387
Published: May 22, 2024
Background
Metabolic
disorders
and
inflammatory
bowel
diseases
(IBD)
have
captured
the
globe
during
Westernisation
of
lifestyle
related
dietary
habits
over
last
decades.
Both
disease
entities
are
characterised
by
complex
heterogeneous
clinical
spectra
linked
to
distinct
symptoms
organ
systems
which,
on
a
first
glimpse,
do
not
many
commonalities
in
practice.
However,
experimental
studies
indicate
common
backbone
mechanisms
metabolic
gut
inflammation,
emerging
evidence
suggests
an
intricate
interplay
between
IBD.
Objective
We
depict
parallels
IBD
diseases,
easily
overlooked
routine.
Design
provide
overview
recent
literature
discuss
implications
morbidity
patients
with
for
researchers,
clinicians
healthcare
providers.
Conclusion
The
Western
diet
microbial
perturbation
serve
as
fuel
inflammation
beyond
gut.
syndrome
increasingly
affect
IBD,
expected
negative
impact
both
risk
complications.
This
concept
implies
that
tackling
obesity
pandemic
exerts
beneficial
effects
health.
Journal of Diabetes,
Journal Year:
2024,
Volume and Issue:
16(10)
Published: Oct. 1, 2024
Abstract
The
global
prevalence
of
diabetes
has
increased
significantly,
leading
to
various
complications
and
a
negative
impact
on
quality
life.
Hyperglycemia
hyperglycemic‐induced
oxidative
stress
(OS)
inflammation
are
closely
associated
with
the
development
progression
type
2
mellitus
(T2D)
its
complications.
This
review
explores
effect
T2D
target
organ
damage
potential
treatments
minimize
this
damage.
paper
examines
pathophysiology
T2D,
focusing
low‐grade
chronic
OS
their
insulin
resistance.
discusses
role
in
microvascular
macrovascular
findings
highlight
mechanisms
by
which
inflammatory
cytokines,
kinases,
reactive
oxygen
species
(ROS)
interfere
signaling
pathways,
impaired
glucose
metabolism
dysfunction.
Lifestyle
interventions,
including
balanced
diet
exercise,
can
help
reduce
OS,
thereby
preventing
controlling
Additionally,
antioxidants
anti‐inflammatory
agents
show
reducing
inflammation.
Some
anti‐diabetic
drugs,
like
pioglitazone,
metformin,
glucagon‐like
peptide‐1
(GLP‐1)
agonists,
may
also
have
effects.
Further
research,
randomized
controlled
trials,
is
needed
evaluate
efficacy
these
interventions.
image
Gut,
Journal Year:
2024,
Volume and Issue:
73(8), P. 1376 - 1387
Published: May 22, 2024
Background
Metabolic
disorders
and
inflammatory
bowel
diseases
(IBD)
have
captured
the
globe
during
Westernisation
of
lifestyle
related
dietary
habits
over
last
decades.
Both
disease
entities
are
characterised
by
complex
heterogeneous
clinical
spectra
linked
to
distinct
symptoms
organ
systems
which,
on
a
first
glimpse,
do
not
many
commonalities
in
practice.
However,
experimental
studies
indicate
common
backbone
mechanisms
metabolic
gut
inflammation,
emerging
evidence
suggests
an
intricate
interplay
between
IBD.
Objective
We
depict
parallels
IBD
diseases,
easily
overlooked
routine.
Design
provide
overview
recent
literature
discuss
implications
morbidity
patients
with
for
researchers,
clinicians
healthcare
providers.
Conclusion
The
Western
diet
microbial
perturbation
serve
as
fuel
inflammation
beyond
gut.
syndrome
increasingly
affect
IBD,
expected
negative
impact
both
risk
complications.
This
concept
implies
that
tackling
obesity
pandemic
exerts
beneficial
effects
health.
