Current Sleep Medicine Reports, Journal Year: 2025, Volume and Issue: 11(1)
Published: Jan. 3, 2025
Language: Английский
Nature Aging, Journal Year: 2024, Volume and Issue: 4(6), P. 761 - 770
Published: June 5, 2024
Language: Английский
Citations
12
Cells, Journal Year: 2024, Volume and Issue: 13(6), P. 474 - 474
Published: March 7, 2024
Parkinson’s disease (PD) is a progressive neurodegenerative characterized by resting tremor, bradykinesia, rigidity, and postural instability that also includes non-motor symptoms such as mood dysregulation. Dopamine (DA) the primary neurotransmitter involved in this disease, but cholinergic imbalance has been implicated. Current intervention PD focused on replenishing central DA, which provides remarkable temporary symptomatic relief does not address neuronal loss progression of disease. It well established nicotinic receptors (nAChRs) can regulate DA release nicotine itself may have neuroprotective effects. Recent studies identified nAChRs nonneuronal cell types, including glial cells, where they inflammatory responses. Given crucial role neuroinflammation dopaminergic degeneration involvement microglia astrocytes response, provide novel therapeutic target prevention and/or treatment PD. In review, following brief discussion PD, we focus cells and, specifically, their pathology treatment.
Language: Английский
Citations
11
Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(9), P. 6590 - 6605
Published: July 19, 2024
Abstract INTRODUCTION The apolipoprotein E gene ( APOE ) is an established central player in the pathogenesis of Alzheimer's disease (AD), with distinct apoE isoforms exerting diverse effects. influences not only amyloid‐beta and tau pathologies but also lipid energy metabolism, neuroinflammation, cerebral vascular health, sex‐dependent manifestations. Furthermore, ancestral background may significantly impact link between AD, underscoring need for more inclusive research. METHODS In 2023, Association convened multidisciplinary researchers at “AAIC Advancements: APOE” conference to discuss various topics, including their roles AD pathogenesis, progress apoE‐targeted therapeutic strategies, updates on models interventions that modulate expression function. RESULTS This manuscript presents highlights from provides overview opportunities further research field. DISCUSSION Understanding apoE's multifaceted will help develop targeted advance field precision medicine. Highlights a disease. exerts numerous effects throughout brain amyloid‐beta, tau, other pathways. AAIC encouraged discussions collaborations understanding role APOE.
Language: Английский
Citations
10
ACS Nano, Journal Year: 2024, Volume and Issue: 18(6), P. 5051 - 5067
Published: Feb. 2, 2024
Modulating the properties of biomaterials in terms host immune response is critical for tissue repair and regeneration. However, it unclear how preference cellular microenvironment manipulates chiral responses under physiological or pathological conditions. Here, we reported that vivo vitro oligopeptide immunosuppressive modulation was achieved by manipulation macrophage polarization using tetrapeptide (Ac-FFFK-OH, marked as FFFK) supramolecular polymers. The results suggested FFFK nanofibers can serve a defense mechanism restoration homeostasis upregulating M2 via Src-STAT6 axis. More importantly, transiently acting STAT6, insufficient to induce sustained program, then passes baton EGR2, thereby continuously maintaining program. It worth noting L-chirality exhibits more potent effect inducing than does D-chirality, leading enhanced reconstruction. These findings elucidate crucial molecular signals mediate chirality-dependent immunosuppression damaged tissues while also providing an effective strategy regulating promoting injury based on self-assembling peptide design.
Language: Английский
Citations
9
Current Sleep Medicine Reports, Journal Year: 2025, Volume and Issue: 11(1)
Published: Jan. 3, 2025
Language: Английский
Citations
1