International Immunopharmacology, Journal Year: 2023, Volume and Issue: 125, P. 111196 - 111196
Published: Nov. 15, 2023
Language: Английский
Immunity, Journal Year: 2023, Volume and Issue: 56(10), P. 2188 - 2205
Published: Oct. 1, 2023
The cancer-immunity cycle provides a framework to understand the series of events that generate anti-cancer immune responses. It emphasizes iterative nature response where killing tumor cells by T initiates subsequent rounds antigen presentation and cell stimulation, maintaining active immunity adapting it evolution. Any step can become rate-limiting, rendering system unable control growth. Here, we update based on remarkable progress past decade. Understanding mechanism checkpoint inhibition has evolved, as our view dendritic in sustaining anti-tumor immunity. We additionally account for role microenvironment facilitating, not just suppressing, response, discuss importance considering tumor's immunological phenotype, "immunotype". While these new insights add some complexity cycle, they also provide targets research therapeutic intervention.
Language: Английский
Citations
355
Nature, Journal Year: 2023, Volume and Issue: 619(7970), P. 616 - 623
Published: June 28, 2023
Language: Английский
Citations
83
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: March 25, 2024
Abstract The innate immune pathway is receiving increasing attention in cancer therapy. This ubiquitous across various cell types, not only cells but also adaptive cells, tumor and stromal cells. Agonists targeting the have shown profound changes microenvironment (TME) improved prognosis preclinical studies. However, to date, clinical success of drugs remains limited. Interestingly, recent studies that activation can paradoxically promote progression. uncertainty surrounding therapeutic effectiveness targeted for a critical issue needs immediate investigation. In this review, we observe role demonstrates heterogeneity, linked development stage, status, specific types. We propose within TME, exhibits multidimensional diversity. diversity fundamentally rooted cellular heterogeneity manifested as variety signaling networks. pro-tumor effect essentially reflects suppression classical pathways potential alternative pathways. Refining our understanding tumor’s network employing appropriate strategies enhance ability harness anti-tumor ultimately bridge gap from application.
Language: Английский
Citations
54
Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)
Published: June 1, 2024
Abstract Significant advancements have been made in the application of chimeric antigen receptor (CAR)-T treatment for blood cancers during previous ten years. However, its effectiveness treating solid tumors is still lacking, necessitating exploration alternative immunotherapies that can overcome significant challenges faced by current CAR-T cells. CAR-based immunotherapy against shows promise with emergence macrophages, which possess robust phagocytic abilities, antigen-presenting functions, and ability to modify tumor microenvironment stimulate adaptive responses. This paper presents a thorough examination latest progress CAR-M therapy, covering both basic scientific studies clinical trials. study examines primary obstacles hindering realization complete potential as well strategies be employed these hurdles. With revolutionary technologies like situ genetic modification, synthetic biology techniques, biomaterial-supported gene transfer, provide wider array resources manipulating tumor-associated we suggest combining advanced methods will result creation new era therapy demonstrates improved efficacy, safety, availability. Graphical
Language: Английский
Citations
20
Advanced Science, Journal Year: 2024, Volume and Issue: 11(14)
Published: Feb. 2, 2024
Abstract Nicotinamide phosphoribosyltransferase (NAMPT) is a metabolic enzyme with key roles in inflammation. Previous studies have examined the consequences of its upregulated expression cancer cells themselves, but are limited respect to role other within tumor microenvironment (TME) during colorectal (CRC) progression. Using single‐cell RNA sequencing (scRNA‐seq) data, it founded that NAMPT highly expressed SPP1 + tumor‐associated macrophages (TAMs), unique subset TAMs associated immunosuppressive activity. A high gene signature correlated worse prognostic outcomes CRC patients. The effect Nampt deletion myeloid compartment mice development explored. deficiency resulted HIF‐1α destabilization, leading reduction M2‐like TAM polarization. caused significant decreases efferocytosis activity macrophages, which enhanced STING signaling and induction type I IFN‐response genes. Expression these genes contributed anti‐tumoral immunity via potentiation cytotoxic T cell TME. Overall, findings suggest NAMPT‐initiated TAM‐specific can be useful predicting poor patient outcomes; strategies aimed at targeting may provide promising therapeutic approach for building an immunostimulatory TME
Language: Английский
Citations
17
Cancer Discovery, Journal Year: 2024, Volume and Issue: 14(3), P. 524 - 545
Published: Jan. 19, 2024
Abstract The limited efficacy of currently approved immunotherapies in EGFR-driven lung adenocarcinoma (LUAD) underscores the need to better understand alternative mechanisms governing local immunosuppression fuel novel therapies. Elevated surfactant and GM-CSF secretion from transformed epithelium induces tumor-associated alveolar macrophage (TA-AM) proliferation, which supports tumor growth by rewiring inflammatory functions lipid metabolism. TA-AM properties are driven increased GM-CSF–PPARγ signaling inhibition airway or PPARγ TA-AMs suppresses cholesterol efflux cells, impairs EGFR phosphorylation restrains LUAD progression. In absence metabolic support, cells compensate increasing synthesis, blocking simultaneous with statin therapy further progression increases proinflammatory immune responses. These results reveal new therapeutic combinations for immunotherapy-resistant EGFR-mutant LUADs demonstrate how cancer can metabolically co-opt through provide nutrients that promote oncogenic growth. Significance: Alternate strategies harnessing anticancer innate immunity required cancers poor response rates T cell–based immunotherapies. This study identifies a targetable, mutually supportive, relationship between macrophages epithelium, is exploited tumors obtain immunologic support sustain proliferation signaling. article featured Selected Articles Issue, p. 384
Language: Английский
Citations
16
Immunity, Journal Year: 2023, Volume and Issue: 56(11), P. 2555 - 2569.e5
Published: Nov. 1, 2023
Language: Английский
Citations
23
Biomarker Research, Journal Year: 2024, Volume and Issue: 12(1)
Published: Sept. 3, 2024
Abstract Tumor cells possess complex immune evasion mechanisms to evade system attacks, primarily through metabolic reprogramming, which significantly alters the tumor microenvironment (TME) modulate cell functions. When a is sufficiently immunogenic, it can activate cytotoxic T-cells target and destroy it. However, tumors adapt by manipulating their pathways, particularly glucose, amino acid, lipid metabolism, create an immunosuppressive TME that promotes escape. These alterations impact function differentiation of non-tumor within TME, such as inhibiting effector T-cell activity while expanding regulatory myeloid-derived suppressor cells. Additionally, these changes lead imbalance in cytokine chemokine secretion, further enhancing landscape. Emerging research increasingly focusing on roles evaluating how reprogrammed metabolism influence functional ultimately aid evasion. Despite our incomplete understanding intricate interactions between cells, connection elements presents significant challenges for cancer immunotherapy. This review highlights altered providing new insights could facilitate development novel immunotherapies.
Language: Английский
Citations
16
Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)
Published: April 5, 2024
Abstract For decades, great strides have been made in the field of immunometabolism. A plethora evidence ranging from basic mechanisms to clinical transformation has gradually embarked on immunometabolism center stage innate and adaptive immunomodulation. Given this, we focus changes immunometabolism, a converging series biochemical events that alters immune cell function, propose roles played by diversified metabolic derivatives enzymes, emphasize key metabolism-related checkpoints distinct types, discuss ongoing upcoming realities treatment. It is expected future research will reduce current limitations immunotherapy provide positive hand responses exert broader therapeutic role.
Language: Английский
Citations
13
Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)
Published: Jan. 18, 2024
Abstract One of the key features cancer is energy metabolic reprogramming which tightly related to proliferation, invasion, metastasis, and chemotherapy resistance. NcRNAs are a class RNAs having no protein-coding potential mainly include microRNAs, lncRNAs circRNAs. Accumulated evidence has suggested that ncRNAs play an essential role in regulating reprogramming, altered networks mediated by primarily drive carcinogenesis expression enzymes transporter proteins. Importantly, accumulated research revealed dysregulated mediate contributing generation therapeutic tolerance. Elucidating molecular mechanism can provide promising metabolism-related targets for treatment as well overcome In conclusion, this review updates latest mechanisms reprogramming.
Language: Английский
Citations
10