Integrated control of leukocyte compartments as a feature of adaptive physiology

Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Conductive Hydrogel Inspires Neutrophil Extracellular Traps to Combat Bacterial Infections in Wounds

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Thetreatment of infected wounds is currently a major challenge in clinical medicine, and enhancing antimicrobial angiogenic capacity one the most common strategies. However, current treatment makes it difficult to balance effect early stage later stages wound healing, leading an increased rate poor prognosis. Here, we present nanoconductive hydrogel EF@S-HGM, consisting HGM with ECGS, FMLP, SWCNT. The host-guest supramolecular macromolecule (HGM) biocompatible can be injected situ wound. endothelial cell growth factor (ECGS) accelerates vascular remodeling repairs by promoting proliferation cells. N-Formyl-Met-Leu-Phe (FMLP) recruits neutrophils increases capacity. Single-walled carbon nanotubes (SWCNT) make conductive, enabling utilize endogenous electric field recruit multiple kinds In addition, found that EF@S-HGM activates glucocorticoid receptor senescence pathway promotes formation NET, which enhances effect. As tissue-engineered skin, conductive promising material for regenerative medicine may provide potential option care significantly improve patient outcomes

Language: Английский

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β-hydroxybutyrate serves as a regulator in ketone body metabolism through lysine β-hydroxybutyrylation

Journal of Biological Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108475 - 108475

Published: April 1, 2025

β-hydroxybutyrate (β-HB) may serve as a signaling metabolite in many physiological processes beyond fuel source for tissues. However, whether and how it is involved ketone body metabolism still unknown. The present study aims to investigate the role of lysine β-hydroxybutyrylation (Kbhb) modification mediated by β-HB regulating metabolic homeostasis both vivo vitro. starvation ketosis type 1 diabetes mouse models were introduced evaluate influence on Kbhb mice. modifications OXCT1 HMGCS2, two rate-limiting enzymes ketogenesis utilization, showed positive correlation with level vitro vivo. levels increased during fasting but decreased after refeeding. all detected tissues minor change since blood non-significantly model. experiments further indicated that mutation at site significantly inhibited enzymatic activity not HMGCS2. SIRT1 CBP identified potential dehydrogenase transferase OXCT1, respectively. Lysine 421 increases its enzyme accumulation, accelerating utilization finally maintaining homeostasis. Our proposes new regulatory mode primarily accumulation.

Language: Английский

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Lactate metabolism and lactylation in cardiovascular disease: novel mechanisms and therapeutic targets

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 27, 2024

Cardiovascular disease (CVD) is responsible for approximately 30% of annual global mortality rates, yet existing treatments this condition are considered less than ideal. Despite being previously overlooked, lactate, a byproduct glycolysis, now acknowledged its crucial role in the cellular functions cardiovascular system. Recent studies have shown that lactate influences proliferation, differentiation, and activation immune cells through modulation post-translational protein modifications, thereby affecting development prognosis disease. Consequently, there has been notable increase interest towards drug targets targeting lactylation cells, prompting further exploration. In light swift advancements domain, review article dedicated to examining potential regulating lactylation, with aim enhancing comprehension intricate field.

Language: Английский

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Crinecerfont in Adult Congenital Adrenal Hyperplasia

New England Journal of Medicine, Journal Year: 2024, Volume and Issue: 391(16), P. 1556 - 1558

Published: Oct. 23, 2024

Language: Английский

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Atypical monocyte dynamics in healthy humans in response to fasting and refeeding are distinguished by fasting HDL and postprandial cortisol

AJP Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 327(2), P. E229 - E240

Published: July 3, 2024

Monocytes are innate immune cells that continuously produced in bone marrow which enter and circulate the vasculature. In response to nutrient scarcity, monocytes migrate back marrow, where, upon refeeding, they rereleased into bloodstream replenish circulation. humans, variability monocyte behavior fasting refeeding has not been characterized. To investigate dynamics we measured blood fluctuations 354 clinically healthy individuals after a 12-h overnight fast at 3 6 h consuming mixed macronutrient challenge meal. Using cluster analysis, identified three distinct behaviors.

Language: Английский

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