The immunology of systemic lupus erythematosus

Nature Immunology, Journal Year: 2024, Volume and Issue: 25(8), P. 1332 - 1343

Published: July 15, 2024

Language: Английский

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TLRs signaling pathway regulation, antibacterial and apoptotic activity of largemouth bass ECSIT during Edwardsiella piscicida infection

Aquaculture, Journal Year: 2024, Volume and Issue: 595, P. 741615 - 741615

Published: Sept. 16, 2024

Language: Английский

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Control of adaptive immunity by pattern recognition receptors

Immunity, Journal Year: 2024, Volume and Issue: 57(4), P. 632 - 648

Published: April 1, 2024

Language: Английский

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MAP Kinase Signaling at the Crossroads of Inflammasome Activation

Immunological Reviews, Journal Year: 2025, Volume and Issue: 329(1)

Published: Jan. 1, 2025

ABSTRACT Inflammasomes are crucial mediators of both antimicrobial host defense and inflammatory pathology, requiring stringent regulation at multiple levels. This review explores the pivotal role mitogen‐activated protein kinase (MAPK) signaling in modulating inflammasome activation through various regulatory mechanisms. We detail recent advances understanding MAPK‐mediated NLRP3 priming, licensing activation, with emphasis on MAPK‐induced activator protein‐1 (AP‐1) ERK1 JNK licensing, TAK1 connecting death receptor to activation. Furthermore, we discuss novel insights into MAPK human NLRP1 focusing MAP3K member ZAKα as a key linking ribosomal stress Lastly, work elucidating how Bacillus anthracis lethal toxin (LeTx) manipulates induce macrophage apoptosis an immune evasion strategy, counteraction this effect genotype‐specific Nlrp1b certain rodent strains.

Language: Английский

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Innate immune sensing of cell death in disease and therapeutics

Nature Cell Biology, Journal Year: 2024, Volume and Issue: 26(9), P. 1420 - 1433

Published: Sept. 1, 2024

Language: Английский

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Immune regulation of host energy metabolism and periodicity of malaria parasites

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2025, Volume and Issue: 380(1918)

Published: Jan. 23, 2025

The synchronization of Plasmodium parasites as they replicate within red blood cells their vertebrate host remains largely unexplored. Understanding this could reveal how optimize lifecycle to maximize transmission, evade the immune response and energy acquisition. Rhythmic replication fulfils some criteria an endogenous oscillator with time day cues potentially provided by temperature, oxygen levels, hormones and/or nutrient availability. Recent research on a rodent malaria model has highlighted that rhythms associated host’s feeding/fasting cycle are crucial factor influencing erythrocytic stages circadian cycle. Innate responses also rhythmic can regulate metabolism, suggesting innate triggered contributes its replication. Here, we outline interplay between metabolism influence timing ’s rhythm, focusing roles cytokine tumour necrosis factor, mitochondrial function metabolites generated tricarboxylic acid in highly activated monocytes. These processes pivotal controlling parasitemia determining disease outcome, better understanding host–parasite interactions may provide new insights for therapeutic interventions against malaria. This article is part Theo Murphy meeting issue ‘Circadian infection immunity’.

Language: Английский

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Novel Insights into Neuroinflammatory Mechanisms in Traumatic Brain Injury: Focus on Pattern Recognition Receptors as Therapeutic Targets

Cytokine & Growth Factor Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Human and Murine Toll-like Receptor-Driven Disease in Systemic Lupus Erythematosus

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5351 - 5351

Published: May 14, 2024

The pathogenesis of systemic lupus erythematosus (SLE) is linked to the differential roles toll-like receptors (TLRs), particularly TLR7, TLR8, and TLR9. TLR7 overexpression or gene duplication, as seen with Y-linked autoimmune accelerator (Yaa) locus agonist imiquimod, correlates increased SLE severity, specific polymorphisms gain-of-function variants are associated enhanced susceptibility severity. In addition, X-chromosome location its escape from inactivation provide a genetic basis for female predominance in SLE. absence TLR8 TLR9 have been shown exacerbate detrimental effects leading upregulated activity disease severity mouse models regulatory functions proposed involve competition endosomal trafficking chaperone UNC93B1. However, recent evidence implies more direct, on activity. association between age-associated B cells (ABCs) autoantibody production positions these potential targets treatment SLE, but lack markers necessitates further research precise therapeutic intervention. Therapeutically, targeting TLRs promising strategy treatment, drugs like hydroxychloroquine already clinical use.

Language: Английский

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Aflatoxin B1-induced liver pyroptosis is mediated by disturbing the gut microbial metabolites: the roles of pipecolic acid and norepinephrine

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 474, P. 134822 - 134822

Published: June 5, 2024

Language: Английский

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Pattern-Recognition Receptors and Immunometabolic Reprogramming: What We Know and What to Explore

Journal of Innate Immunity, Journal Year: 2024, Volume and Issue: 16(1), P. 295 - 323

Published: Jan. 1, 2024

Evolutionarily, immune response is a complex mechanism that protects the host from internal and external threats. Pattern-recognition receptors (PRRs) recognize MAMPs, PAMPs, DAMPs to initiate protective pro-inflammatory response. PRRs are expressed on cell membranes by TLR1, 2, 4, 6 in cytosolic organelles TLR3, 7, 8, 9, NLRs, ALRs, cGLRs. We know their downstream signaling pathways controlling immunoregulatory However, impact of metabolic control cells pro- anti-inflammatory activity has not been discussed extensively.

Language: Английский

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