The Novel Role of the NLRP3 Inflammasome in Mycotoxin-Induced Toxicological Mechanisms DOI Creative Commons
Chengshui Liao,

Fengru Xu,

Zuhua Yu

et al.

Veterinary Sciences, Journal Year: 2024, Volume and Issue: 11(7), P. 291 - 291

Published: June 28, 2024

Mycotoxins are secondary metabolites produced by several fungi and moulds that exert toxicological effects on animals including immunotoxicity, genotoxicity, hepatotoxicity, teratogenicity, neurotoxicity. However, the mechanisms of mycotoxins complex unclear. The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin containing 3 (NLRP3) inflammasome is a multimeric cytosolic protein composed NLRP3 sensor, ASC adapter protein, caspase-1 effector. Activation plays crucial role in innate immune defence homeostatic maintenance. Recent studies have revealed activation linked to tissue damage inflammation induced mycotoxin exposure. Thus, this review summarises latest advancements research roles pathogenesis exposure multiple mycotoxins, deoxynivalenol, aflatoxin B1, zearalenone, T-2 toxin, ochratoxin A, fumonisim pyroptosis-related factors inflammation-related vitro vivo pharmacological inhibition specific nonspecific inhibitors summarized examined. This comprehensive contributes better understanding toxicity provides novel insights for pharmacologically targeting as anti-inflammatory agent against

Language: Английский

Mechanistic insights into ferroptosis and apoptosis pathways: Synergistic effects of multi-organ toxicity and transgenerational effects induced by co-exposure of epoxiconazole and aflatoxin B1 in zebrafish DOI Creative Commons

Ruike Wang,

Qi Zhang, Gang Chen

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
SIRT1 Regulates Fumonisin B1-Induced LMH Cell PANoptosis and Antagonism of Lycopene DOI
Xueqi Wang, Yuan‐Hang Chang,

Xiaochun Wang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Mycotoxin contamination is a universal agricultural problem and critical health issue. Fumonisin B1 (FB1) one of the most toxic extensive fumonisins that exist in various agro-products foods. Lycopene (LYC), as natural carotenoid, becoming increasingly favored owing to its oxidation resistance. Here, we aim explore mechanism FB1-induced hepatotoxicity antagonism LYC. In this study, our findings indicated FB1 induced mitochondrial structure damage loss function chicken hepatocytes. Furthermore, upregulated expression PANoptosis-related signal molecules. also reduced levels SIRT1 Ac-FOXO1 protein expression, which then inhibited mitophagy. However, LYC relieved these alterations. Most importantly, knockdown protective effects PANoptosis. Our study provides evidence for role mycotoxin-induced hepatocyte injury points potential target liver protection.

Language: Английский

Citations

1
Gut microbiota in health and disease: advances and future prospects DOI Creative Commons
Y J Zhang, Hong Wang, Yingpeng Sang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Nov. 20, 2024

Abstract The gut microbiota plays a critical role in maintaining human health, influencing wide range of physiological processes, including immune regulation, metabolism, and neurological function. Recent studies have shown that imbalances composition can contribute to the onset progression various diseases, such as metabolic disorders (e.g., obesity diabetes) neurodegenerative conditions Alzheimer's Parkinson's). These are often accompanied by chronic inflammation dysregulated responses, which closely linked specific forms cell death, pyroptosis ferroptosis. Pathogenic bacteria trigger these death pathways through toxin release, while probiotics been found mitigate effects modulating responses. Despite insights, precise mechanisms influences diseases remain insufficiently understood. This review consolidates recent findings on impact immune‐mediated inflammation‐associated conditions. It also identifies gaps current research explores potential advanced technologies, organ‐on‐chip models microbiome–gut–organ axis, for deepening our understanding. Emerging tools, single‐bacterium omics spatial metabolomics, discussed their promise elucidating microbiota's disease development.

Language: Английский

Citations

7
From Inflammasomes to Pyroptosis: Molecular Mechanisms in Chronic Intestinal Diseases — Opportunity or Challenge? DOI Creative Commons
Jintao Fang,

Weihan Zhu,

Dian Yu

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 3349 - 3360

Published: March 1, 2025

Pyroptosis is a unique form of programmed cell death characterized by intense inflammation. It involves the activation Gasdermin proteins, which membrane pores, leading to rapid rupture and release inflammatory molecules. Unlike other types death, pyroptosis has distinct mechanisms plays complex role in chronic intestinal diseases, including bowel disease, fibrosis, infectious enteritis, colorectal cancer. This review comprehensively examines how influences disease development progression while exploring therapeutic potential targeting pyroptosis-related pathways. Moreover, interplay between gut microbiota summarized, highlighting its critical pathogenesis disorders. A deeper understanding these diseases may provide valuable insights for future research contribute innovative strategies gastroenterology.

Language: Английский

Citations

0
Optimizing Fermentation of Morus nigra L. Residues with Schizophyllum commune to Enhance Anthocyanin Release and Anti-Inflammatory Activity via Pyroptosis Pathway Modulation DOI Creative Commons

Lin Ye,

Qin Hu, Ying Lin

et al.

Fermentation, Journal Year: 2025, Volume and Issue: 11(3), P. 145 - 145

Published: March 14, 2025

Morus nigra L. is rich in anthocyanins and other active ingredients, but its extraction residues pose a burden on the environment. In present study, residue resource utilization was achieved through liquid fermentation of Schizophyllum commune, with aim enhancing anthocyanin solubilization evaluating anti-inflammatory activity. Response surface methodology used to optimize parameters quantify fractions by HPLC. The effect evaluated using lipopolysaccharide-induced inflammation model human foreskin fibroblast (BJ cell), interaction cyanidin-3-O-glucoside (C3G) NLRP3, key target pyroptosis pathway, resolved molecular docking. Our results indicated that optimal conditions (substrate 3.4%, inoculum 9%, time 50 h) enabled total reach 85.1 μg/mL, which C3G content elevated 66.7 μg/mL (release efficiency 83.9%). fermented filtrate effectively promoted BJ cell proliferation inhibited inflammatory response, signaling pathway playing significant role. Molecular docking confirmed binds strongly NLRP3 protein. This technology provides new strategy for high-value development natural drugs.

Language: Английский

Citations

0
The Novel Role of the NLRP3 Inflammasome in Mycotoxin-Induced Toxicological Mechanisms DOI Creative Commons
Chengshui Liao,

Fengru Xu,

Zuhua Yu

et al.

Veterinary Sciences, Journal Year: 2024, Volume and Issue: 11(7), P. 291 - 291

Published: June 28, 2024

Mycotoxins are secondary metabolites produced by several fungi and moulds that exert toxicological effects on animals including immunotoxicity, genotoxicity, hepatotoxicity, teratogenicity, neurotoxicity. However, the mechanisms of mycotoxins complex unclear. The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin containing 3 (NLRP3) inflammasome is a multimeric cytosolic protein composed NLRP3 sensor, ASC adapter protein, caspase-1 effector. Activation plays crucial role in innate immune defence homeostatic maintenance. Recent studies have revealed activation linked to tissue damage inflammation induced mycotoxin exposure. Thus, this review summarises latest advancements research roles pathogenesis exposure multiple mycotoxins, deoxynivalenol, aflatoxin B1, zearalenone, T-2 toxin, ochratoxin A, fumonisim pyroptosis-related factors inflammation-related vitro vivo pharmacological inhibition specific nonspecific inhibitors summarized examined. This comprehensive contributes better understanding toxicity provides novel insights for pharmacologically targeting as anti-inflammatory agent against

Language: Английский

Citations

2