Immunity,
Journal Year:
2025,
Volume and Issue:
58(3), P. 535 - 554
Published: March 1, 2025
SummaryLactate,
the
end
product
of
both
anaerobic
and
aerobic
glycolysis
in
proliferating
growing
cells—with
latter
process
known
as
Warburg
effect—is
historically
considered
a
mere
waste
cell
tissue
metabolism.
However,
research
over
past
ten
years
has
unveiled
multifaceted
functions
lactate
that
critically
shape
impact
cellular
biology.
Beyond
serving
fuel
source,
is
now
to
influence
gene
expression
through
histone
modification
function
signaling
molecule
impacts
wide
range
activities.
These
properties
have
been
particularly
studied
context
adaptive
innate
immune
responses.
Here,
we
review
diverse
roles
regulation
system
during
homeostasis
disease
pathogenesis
(including
cancer,
infection,
cardiovascular
diseases,
autoimmunity).
Furthermore,
describe
recently
proposed
therapeutic
interventions
for
manipulating
metabolism
human
diseases.
Theranostics,
Journal Year:
2025,
Volume and Issue:
15(5), P. 1787 - 1821
Published: Jan. 2, 2025
Lactate
is
an
indispensable
substance
in
various
cellular
physiological
functions
and
plays
regulatory
roles
different
aspects
of
energy
metabolism
signal
transduction.
Lactylation
(Kla),
a
key
pathway
through
which
lactate
exerts
its
functions,
has
been
identified
as
novel
posttranslational
modification
(PTM).
Research
indicates
that
Kla
essential
balancing
mechanism
variety
organisms
involved
many
biological
processes
pathways.
closely
related
to
disease
development
represents
potential
important
new
drug
target.
In
line
with
existing
reports,
we
searched
for
newly
discovered
sites
on
histone
nonhistone
proteins;
reviewed
the
mechanisms
(particularly
focusing
enzymes
directly
reversible
regulation
Kla,
including
"writers"
(modifying
enzymes),
"readers"
(modification-binding
"erasers"
(demodifying
enzymes);
summarized
crosstalk
between
PTMs
help
researchers
better
understand
widespread
distribution
diverse
functions.
Furthermore,
considering
"double-edged
sword"
role
both
pathological
contexts,
this
review
highlights
"beneficial"
states
(energy
metabolism,
inflammatory
responses,
cell
fate
determination,
development,
etc.)
"detrimental"
pathogenic
or
inducive
effects
processes,
particularly
malignant
tumors
complex
nontumor
diseases.
We
also
clarify
molecular
health
disease,
discuss
feasibility
therapeutic
Finally,
describe
detection
technologies
their
applications
diagnosis
clinical
settings,
aiming
provide
insights
treatment
diseases
accelerate
translation
from
laboratory
research
practice.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 10, 2025
Lactate,
long
viewed
as
a
byproduct
of
glycolysis
and
metabolic
waste.
Initially
identified
within
the
context
yogurt
fermentation,
lactate's
role
extends
beyond
culinary
applications
to
its
significance
in
biochemical
processes.
Contemporary
research
reveals
that
lactate
functions
not
merely
terminal
product
but
also
nexus
for
initiating
physiological
pathological
responses
body.
Lysine
lactylation
(Kla),
novel
post-translational
modification
(PTM)
proteins,
has
emerged
pivotal
mechanism
by
which
exerts
regulatory
influence.
This
epigenetic
potential
alter
gene
expression
patterns,
thereby
impacting
Increasing
evidence
indicates
correlation
between
adverse
prognosis
various
malignancies.
Consequently,
this
review
article
aims
encapsulate
proteins
interact
with
lactate,
elucidate
tumorigenesis
progression,
explore
therapeutic
targets
afforded
modulation
lactylation.
The
objective
is
clarify
oncogenic
provide
strategic
framework
future
directions
burgeoning
field.
Translational Cancer Research,
Journal Year:
2025,
Volume and Issue:
14(1), P. 296 - 312
Published: Jan. 1, 2025
The
occurrence
rate
of
liver
cancer
is
increasing
in
recent
years.
significance
lactylation
tumor
cells
should
not
be
neglected.
This
study
aimed
to
discover
a
gene
signature
related
that
can
used
for
diagnostic
applications.
Data
were
downloaded
from
Cancer
Genome
Atlas
(TCGA),
GSE14520,
GSE84402,
and
GSE62232
datasets.
Differential
analysis
random
forest
performed
hepatocellular
carcinoma
(HCC).
Receiver
operating
characteristic
(ROC)
curve
was
evaluate
efficiency,
logistic
regression
established
obtain
the
risk
score
equation.
Besides,
expression
genes
identified
by
TCGA
database
verified
real-time
quantitative
polymerase
chain
reaction
(RT-PCR).
In
order
analyze
prognostic
performance,
patients
diagnosed
with
HCC
stratified
into
either
high
or
low
categories
based
on
median
score.
addition,
immunotherapy
drug
sensitivity
groups
assessed.
performance
model
validated
Gene
Expression
Omnibus
(GEO)
dataset.
had
worse
outcomes
than
those
database.
ROC
curves
showed
characteristics
lactylation-related
good
predictive
capability.
Furthermore,
we
developed
nomogram
patients,
utilizing
data
resources
TCGA.
Finally,
terms
assessing
potency
group
lower
Tumor
Immune
Dysfunction
Exclusion
(TIDE)
score,
indicating
response
immunotherapy.
Our
identification
associated
presents
promising
avenue
development
targeted
immunotherapeutic
strategies.
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: March 5, 2025
Targeting
the
dysregulation
of
epigenetic
mechanisms
in
cancer
has
emerged
as
a
promising
therapeutic
strategy.
Although
significant
rationale
progress
therapies
blocking
cells,
how
regulation
shapes
tumor
microenvironment
(TME)
and
establishes
antitumor
immunity
remains
less
understood.
Recent
study
focus
been
put
on
epigenetic-mediated
changes
fate
immune
including
differentiation,
expansion,
recruitment,
functionalization,
exhaustion
T
natural
killer
(NK)
tumor-associated
macrophages
(TAMs),
dendritic
cells
(DCs),
myeloid-derived
suppressor
(MDSCs),
B
within
TME.
Here,
we
review
latest
molecular
clinical
insights
into
DNA
modifications,
histone
modification,
epitranscriptome-related
regulations
shape
various
cancers.
We
also
discuss
opportunities
for
leveraging
to
improve
immunotherapies.
This
provides
foundations
proposes
future
direction
combination
therapies.
