Neuroscience, Journal Year: 2024, Volume and Issue: 564, P. 236 - 242
Published: Nov. 22, 2024
Language: Английский
Trends in Immunology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
1
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 29, 2025
Abstract Although IgA + long-lived plasma cells (LLPCs) generated following mucosal viral infection provide durable protection against reinfection, little is known about their generation. Here, we show that oral RV induces gut-resident LLPCs produce highly mutated protective IgA. Unlike RV-specific IgG LLPCs, were independently of MHCII expression by dendritic – rather B was both necessary and sufficient. cell also sufficient to induce a unique population T-bet follicular helper T (T FH 1) which crucial for LLPC accumulation in the gut via IFNγ- CXCR3-dependent mechanisms. Similar infection, 1 required influenza-specific response. However, unlike not suggesting operation site-specific priming Collectively, our data reveal unconventionally primed support responses infections.
Language: Английский
Citations
0
Cells, Journal Year: 2025, Volume and Issue: 14(6), P. 457 - 457
Published: March 19, 2025
Colorectal epithelium was the first long-term 3D organoid culture established in vitro. Identification of key components essential for survival stem cell niche allowed an indefinite propagation these cultures and modulation their differentiation into various lineages mature intestinal epithelial cells. While methods were eventually adapted to establish organoids from different organs, colorectal remain a pioneering model development new applications health disease. Several basic applicative aspects culture, modeling, monitoring testing are analyzed this review. We also tackle ethical problems biobanking distribution precious research tools, frequently confined laboratory origin or condemned destruction at end project.
Language: Английский
Citations
0
Molecular Immunology, Journal Year: 2025, Volume and Issue: 182, P. 11 - 19
Published: March 30, 2025
Language: Английский
Citations
0
Journal of Immunology Research, Journal Year: 2025, Volume and Issue: 2025(1)
Published: Jan. 1, 2025
Colorectal cancer (CRC) stands as one of the tumors with globally high incidence and mortality rates. In recent years, researchers have extensively explored role tumor immune microenvironment (TME) in CRC, highlighting crucial influence cell populations driving progression shaping therapeutic outcomes. The TME encompasses an array cellular noncellular constituents, spanning cells, myeloid tumor-associated fibroblasts, among others. However, composition within is highly dynamic, evolving throughout different stages progression. These shifts subpopulation proportions lead to a gradual transition response, shifting from early antitumor growth late-stage environment that supports survival. Therefore, it further investigate understand complex interactions various TME. this review, we explore key components varying origins, subpopulations shared elements CRC TME, examining their interconnections critical considerations for developing personalized precise immunotherapy strategies.
Language: Английский
Citations
0
Current Opinion in Immunology, Journal Year: 2025, Volume and Issue: 94, P. 102557 - 102557
Published: April 18, 2025
Adaptive immunity towards self-antigens (autoimmunity) and intestinal commensal microbiota is a key feature of inflammatory bowel disease (IBD). Considering mucosal adaptive from holobiont perspective, where the host its microbiome form single physiological unit, emphasises challenge avoiding damaging responses to self-antigen symbiotic microbial communities in gut while protecting against potential pathogens. Intestinal tolerance mechanisms prevent maladaptive T B cell microbial, environmental, self-antigens, which drive inflammation. We discuss spectrum antimicrobial autoantibody highlight by common IBD-associated immune contribute disease.
Language: Английский
Citations
0
Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)
Published: April 24, 2025
Microglia and Th17 cells are the major immunopathogenic in multiple sclerosis its animal model of immune aspects, experimental autoimmune encephalomyelitis (EAE). While studies have highlighted distinct roles microglia EAE, it remains unclear whether microglia, as potential professional antigen-presenting cells, activate stabilize effector program EAE-pathogenic vivo; if so, could turn reinforce active state microglia. Our data demonstrate an array mouse models, including active/passive-EAE transgenic mice, a microglia-Th17 feed-forward activation loop drives EAE disease progression through mechanism dependent on both MHC-II, proinflammatory cytokines, inflammatory chemokines well STING→NF-κB pathway cytokines produced by pathogenic cells. We also captured identified molecular properties loop, which two-cell entities microglia-Th17, proved them functional units antigen presentation bi-directional between two cell types. Moreover, ACT001, orphan drug to treat glioblastoma, disrupts this inhibiting thereby alleviating EAE. These findings emphasize importance interactions activations neuroinflammation, provide rationale for further investigation ACT001 therapeutic option diseases driven similar mechanisms.
Language: Английский
Citations
0
Immunity, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
The central nervous system (CNS) was once perceived as entirely shielded from the immune system, protected behind blood-brain barrier and thought to lack lymphatic drainage. However, recent evidence has challenged many dogmas in neuroimmunology. Indeed, by means of glymphatics, brain-derived "waste" deep within CNS mobilizes toward immunologically active brain borders, where meningeal vessels are appropriately positioned drain antigens periphery. Accordingly, presentation self-peptides emerges at brain's borders drives T cell responses with suppressive properties, critical allowing immunosurveillance while limiting aberrant reactivity. Taking into consideration these concepts, we further discuss how inflammation, aging, neurodegenerative diseases potentially reshape repertoire self-antigens cells, disrupting healthy dialogue between system. Collectively, this evolving perspective unveils new therapeutic avenues for pathologies.
Language: Английский
Citations
0
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(5), P. 609 - 609
Published: May 4, 2025
The oral delivery of DNA/RNA nanoparticles represents a transformative approach in immunotherapy and vaccine development. These enable targeted immune modulation by delivering genetic material to specific cells the gut-associated system, triggering both mucosal systemic responses. Unlike parenteral administration, route offers unique immunological environment that supports tolerance activation, depending on formulation design. This review explores underlying mechanisms nanoparticles, their design strategies, recent advances application. Emphasis is placed strategies overcome physiological barriers such as acidic pH, enzymatic degradation, mucus entrapment, epithelial tight junctions. Special attention given role lymphoid tissue mediating responses therapeutic potential these systems platforms, food allergies, autoimmune diseases, chronic inflammation. Despite challenges, nanoparticle support translation technologies into clinical applications for immunomodulation vaccination.
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 125053 - 125053
Published: Dec. 1, 2024
Language: Английский
Citations
1