Mechanistic Insights into Cellular and Molecular Basis of Protein‐Nanoplastic Interactions DOI Open Access
Goutami Naidu, Nupur Nagar, Krishna Mohan Poluri

et al.

Small, Journal Year: 2023, Volume and Issue: 20(5)

Published: Oct. 2, 2023

Abstract Plastic waste is ubiquitously present across the world, and its nano/sub‐micron analogues (plastic nanoparticles, PNPs), raise severe environmental concerns affecting organisms’ health. Considering direct indirect toxic implications of PNPs, their biological impacts are actively being studied; lately, with special emphasis on cellular molecular mechanistic intricacies. Combinatorial OMICS studies identified proteins as major regulators PNP mediated toxicity via activation oxidative enzymes generation ROS. Alteration protein function by PNPs results in DNA damage, organellar dysfunction, autophagy, thus resulting inflammation/cell death. The basis these endeavors fine‐tuned at level structural alterations physiological relevance. Detailed biophysical such protein‐PNP interactions evidenced prominent modifications architecture conformational energy landscape. Another essential aspect includes bioenzymatic plastic degradation perspective, interactive units plastics essentially nano‐sized. Combining all attributes interactions, current review comprehensively documented contemporary understanding concerned light cellular, molecular, kinetic/thermodynamic details. Additionally, applicatory, economical facet biogeochemical cycle enzymatic advances pertaining to has also been discussed.

Language: Английский

Surface interaction of vancomycin with polystyrene microplastics and its effect on human serum albumin DOI

Lydia Ann Vinod,

Durgalakshmi Rajendran,

Murugesh Shivashankar

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 256, P. 128491 - 128491

Published: Dec. 2, 2023

Language: Английский

Citations

8
A Comparative Study on the Interaction Between Protein and PET Micro/Nanoplastics: Structural and Surface Characteristics of Particles and Impacts on Lung Carcinoma Cells (A549) and Staphylococcus aureus DOI
Aslı Baysal, Hasan Saygın, Ahu Soyocak

et al.

Environmental Toxicology, Journal Year: 2024, Volume and Issue: 39(11), P. 4899 - 4926

Published: June 25, 2024

ABSTRACT The interaction between particles and proteins is a key factor determining the toxicity responses of particles. Therefore, this study aimed to examine emerging pollutant polyethylene terephthalate micro/nanoplastics from water bottles with bovine serum albumin. physicochemical characteristics were investigated using nuclear magnetic resonance, x‐ray diffraction, Fourier transform infrared, dynamic light scattering, energy dispersive spectroscopy after exposure various concentrations durations protein. Furthermore, impact protein‐treated on biological activities was examined mitochondrial activity membrane integrity A549 cells biofilm production Staphylococcus aureus . structural revealed an For instance, assignment protein‐related new proton signals (e.g., CH 2 , methylene protons CH O), changes in available s 3 ), crystallinity, functional groups, elemental ratios, zeta potentials (−11.3 ± 1.3 −12.4 1.7 25.5 2.3 mV), particle size (395 76 496 60 866 82 nm) significantly observed protein treatment. In addition, loading (0.012–0.027 mM) releasing (0.008–0.013 also showed similar characteristics. Moreover, cell‐based changed regarding surface efficiencies example, insignificant (2%–10%) significant (12%–28%) increased compared control, reductions bacterial (5%–40%) many cases specifically at low dose all treatment stages (13%–46% reduction) observed.

Language: Английский

Citations

2
Interaction of antidiabetic formulation with nanoplastics and its binary influence on plasma protein DOI Open Access

Durgalakshmi Rajendran,

Rinku Polachirakkal Varghese,

C. George Priya Doss

et al.

Environmental Toxicology and Pharmacology, Journal Year: 2023, Volume and Issue: 102, P. 104249 - 104249

Published: Aug. 18, 2023

Language: Английский

Citations

6
The occurrence of microplastic in marine ecosystems in the Middle East: A review DOI
Walied M. Alarif, Fitri Budiyanto, Nahed O. Bawakid

et al.

Regional Studies in Marine Science, Journal Year: 2023, Volume and Issue: 67, P. 103208 - 103208

Published: Sept. 22, 2023

Language: Английский

Citations

6
Mechanistic Insights into Cellular and Molecular Basis of Protein‐Nanoplastic Interactions DOI Open Access
Goutami Naidu, Nupur Nagar, Krishna Mohan Poluri

et al.

Small, Journal Year: 2023, Volume and Issue: 20(5)

Published: Oct. 2, 2023

Abstract Plastic waste is ubiquitously present across the world, and its nano/sub‐micron analogues (plastic nanoparticles, PNPs), raise severe environmental concerns affecting organisms’ health. Considering direct indirect toxic implications of PNPs, their biological impacts are actively being studied; lately, with special emphasis on cellular molecular mechanistic intricacies. Combinatorial OMICS studies identified proteins as major regulators PNP mediated toxicity via activation oxidative enzymes generation ROS. Alteration protein function by PNPs results in DNA damage, organellar dysfunction, autophagy, thus resulting inflammation/cell death. The basis these endeavors fine‐tuned at level structural alterations physiological relevance. Detailed biophysical such protein‐PNP interactions evidenced prominent modifications architecture conformational energy landscape. Another essential aspect includes bioenzymatic plastic degradation perspective, interactive units plastics essentially nano‐sized. Combining all attributes interactions, current review comprehensively documented contemporary understanding concerned light cellular, molecular, kinetic/thermodynamic details. Additionally, applicatory, economical facet biogeochemical cycle enzymatic advances pertaining to has also been discussed.

Language: Английский

Citations

6