Micro- and nanoplastics concepts for particle and fibre toxicologists

Particle and Fibre Toxicology, Journal Year: 2024, Volume and Issue: 21(1)

Published: April 2, 2024

Abstract Micro- and nanoplastic particles (MNP) are omnipresent as either pollution or intentionally used in consumer products, released from packaging even food. There is an exponential increase the production of plastics. With realization bioaccumulation humans, toxicity research quickly expanding. a rapid number papers published on potential implications exposure to MNP which necessitates call for quality criteria be applied when doing research. At present, most describe effects commercially available polymer (mostly polystyrene) beads that typically not greatest concern. This fault community, necessarily, MNPs humans exposed usually quantities needed toxicological innovations supply environmentally-relevant models. In addition, like we have learned decades with particulate matter engineered nanomaterials, sample physicochemical characteristics preparation can major impacts biological responses interpretation findings. Lastly, dosimetry may pose challenges (1) seeing early evidence plastics already human body at quite high levels difficult achieve acute vitro studies (2) diets fed preclinical commentary highlights pitfalls recommendations particle fibre toxicologists should considered performing disseminating

Language: Английский

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Ingested Polystyrene Micro-Nanoplastics Increase the Absorption of Co-Ingested Arsenic and Boscalid in an In Vitro Triculture Small Intestinal Epithelium Model

Microplastics, Journal Year: 2025, Volume and Issue: 4(1), P. 4 - 4

Published: Jan. 7, 2025

Micro-nano plastics (MNPs) are emerging environmental and food contaminants that raising serious health concerns. Due to the polycontamination of web with pollutants (EPs), now MNPs, co-ingestion EPs MNPs is likely occur, potential synergistic effects such co-ingestions completely unstudied. In this study, we therefore sought determine two model EPs, arsenic boscalid, on uptake toxicity 25 1000 nm polystyrene (PS-25 PS-1000), vice versa, employing a triculture small intestinal epithelium combined simulated digestion. 24 h exposures, neither nor + caused significant toxicity. The presence PS-25 significantly increased (from 0.0 5.8%, p < 0.001) translocation 5.2 9.8%, 0.05) but had no effect boscalid or translocation, whereas PS-1000 either EP. both PS was also by rising from 10.6 19.5% (p 0.01) for 4.8 8.5% PS-1000. These findings highlight need further studies assess MNP-EP interactions possible adverse impacts.

Language: Английский

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Micro-nanoscale polystyrene co-exposure impacts the uptake and translocation of arsenic and boscalid by lettuce (Lactuca sativa)

NanoImpact, Journal Year: 2025, Volume and Issue: 37, P. 100541 - 100541

Published: Jan. 1, 2025

Language: Английский

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The association between micro- and nano-plastics and cardiovascular outcomes: a comprehensive review

Toxicology and Environmental Health Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Language: Английский

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Nanoplastics in focus: Exploring interdisciplinary approaches and future directions

NanoImpact, Journal Year: 2025, Volume and Issue: unknown, P. 100544 - 100544

Published: Jan. 1, 2025

Language: Английский

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Size-Dependent Pulmonary Toxicity and Whole-Body Distribution of Inhaled Micro/Nanoplastic Particles in Male Mice from Chronic Exposure

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

The ubiquitous presence of micro/nanoplastics (MP/NP) in the atmosphere has raised significant concerns about their potential health risks through inhalation, yet effects natural respiratory exposure remain underexplored. This study addresses this critical knowledge void by utilizing a whole-body inhalation system to investigate distribution, accumulation, and pulmonary toxicity polystyrene MP/NP (1.5 × 105 particles/m3) male ICR mice (n = 16/group). Fluorescently labeled revealed highest particle accumulation lungs, followed bloodstream spleen, with minimal detection brain. Unsurprisingly, 80 nm nanoplastics displayed greater intertissue transport efficiency than 1 μm microplastics. Chronic both microplastics disrupted oxidative balance exacerbated stress within extracellular environment lungs. impaired antioxidant defenses intra- metabolism led inflammation, apoptosis, fibrosis. Intriguingly, induced more severe smaller counterparts, promoting epithelial-mesenchymal transition These findings underscore need for nuanced understanding size-dependent toxicities inhalable plastic particles highlight posed airborne MP/NP.

Language: Английский

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In vitro cell-transforming potential of secondary polyethylene terephthalate and polylactic acid nanoplastics

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 469, P. 134030 - 134030

Published: March 13, 2024

Continuous exposure to plastic pollutants may have serious consequences on human health. However, most toxicity assessments focus non-environmentally relevant particles and rarely investigate long-term effects such as cancer induction. The present study assessed the carcinogenic potential of two secondary nanoplastics: polyethylene terephthalate (PET) generated from bottles, a biodegradable polylactic acid material, respective examples environmentally existing new bioplastics. Pristine polystyrene nanoplastics were also included for comparison. A broad concentration range (6.25 – 200 μg/mL) each nanoplastic was tested in both initiation promotion conditions regulatory assessment-accepted vitro Bhas 42 cell transformation assay. Parallel cultures allowed confirmation efficient cellular internalisation three nanoplastics. Cell growth enhanced by assay, PET conditions. Moreover, number transformed foci significantly increased only highest which showed dose-dependency, indicating that nano can act non-genotoxic tumour promotor. Together, these findings support risk assessment raise concerns regarding whether real-life co-exposure other environmental result synergistic capacities. Secondary (NPLs) waste degradation bioaccumulate tissues cause cancer. Currently, information NPL carcinogenicity remains scarce. By using we first time NPLs, bioplastic, widely spread petroleum-based alternative, respectively. Notably, accelerated bioplastics has been associated with an release NPLs into environment. data will serve plastics.

Language: Английский

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Exploring the potential and challenges of developing physiologically-based toxicokinetic models to support human health risk assessment of microplastic and nanoplastic particles

Environment International, Journal Year: 2024, Volume and Issue: 186, P. 108617 - 108617

Published: March 30, 2024

Microplastics (MPs) and nanoplastics (NPs) pollution has emerged as a significant widespread environmental issue. Humans are inevitably exposed to MPs NPs via ingestion, inhalation, dermal contacts from various sources. However, mechanistic knowledge of their distribution, interaction, potency in the body is still lacking. To address this gap, we have undertaken task elucidating toxicokinetic (TK) behaviors NPs, aiming provide information for constructing conceptual physiologically based (PBTK) model support silico modeling approaches. Our effort involved thorough examination existing literature data collation on presence human vitro/ex vivo/in vivo biodistribution across cells tissues. By comprehending absorption, metabolism, excretion mechanisms relation physicochemical attributes, established foundational understanding link between external exposure internal tissue dosimetry. We observed that particle size surface chemistry been thoroughly explored previous experimental studies. certain such polymer type, shape, biofilm/biocorona, warrant attention further examination. discussed fundamental disparities TK properties MPs/NPs those engineered nanoparticles. proposed preliminary PBTK framework with several possible approaches challenges investigation. Overall, article provides comprehensive compilation MPs/NPs, critical overview processes mechanisms, proposes potential approaches, particularly regarding applicability system, outlines future perspectives developing models integration into health risk assessment NPs.

Language: Английский

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Mechanisms of ingested polystyrene micro-nanoplastics (MNPs) uptake and translocation in an in vitro tri-culture small intestinal epithelium

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 473, P. 134706 - 134706

Published: May 22, 2024

Micro and nanoplastics (MNPs) are now ubiquitous contaminants of food water. Many cellular animal studies have shown that ingested MNPs can breach the intestinal barrier to reach circulation. To date however, mechanisms involved in absorption not been investigated with physiologically relevant models, thus remain unknown. We employed vitro simulated digestion, a tri-culture small epithelium model, panel inhibitors assess contributions possible 26 nm carboxylated polystyrene (PS26C) MNPs. Inhibition ATP synthesis reduced translocation by only 35 %, suggesting uptake both active endocytic pathways passive diffusion. Translocation was also decreased inhibition dynamin clathrin, involvement clathrin mediated endocytosis (CME) fast endophilin-mediated (FEME). actin polymerization significantly translocation, macropinocytosis or phagocytosis. However, Na

Language: Английский

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A review on toxicity mechanism and risk factors of nanoparticles in respiratory tract

Toxicology, Journal Year: 2024, Volume and Issue: 504, P. 153781 - 153781

Published: March 15, 2024

Language: Английский

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