Particle and Fibre Toxicology,
Journal Year:
2024,
Volume and Issue:
21(1)
Published: Sept. 27, 2024
There
has
been
an
exponential
increase
in
the
number
of
studies
reporting
on
toxicological
effects
associated
with
exposure
to
nano
and
microplastic
particles
(NMPs).
The
majority
these
studies,
however,
have
used
monodispersed
polystyrene
microspheres
(PSMs)
as
'model'
particles.
Here
we
review
differences
between
manufacture
resulting
physicochemical
properties
commerce
PSMs
most
commonly
toxicity
studies.
Ecotoxicology and Environmental Safety,
Journal Year:
2025,
Volume and Issue:
293, P. 118007 - 118007
Published: March 1, 2025
The
increasing
use
of
plastic
polymers
in
3D
printing
applications
may
lead
to
human
exposure
micro-
and
nanoplastics
(MNPLs),
raising
concerns
regarding
adverse
health
consequences
such
as
cancer
induction.
Little
attention
has
been
given
MNPLs
originated
at
the
end
life
cycle
3D-printed
objects
because
mechanical
environmental
degradation
waste.
This
study
assessed
carcinogenic
potential
secondary
generated
through
cryomilling
using
validated
vitro
Bhas
42
cell
transformation
assay
(CTA).
Three-dimensional
were
printed
four
types
polycarbonate
(PC)-
polypropylene
(PP)-modified
thermoplastic
filaments,
undoped
doped
with
single-walled
carbon
nanotubes
(PC-CNT)
silver
nanoparticles
(PP-Ag),
respectively.
(<
5
µm)
following
a
three-step
top-down
process
thoroughly
characterized.
cells
treated
once
(initiation
assay)
or
repeatedly
(promotion
several
concentrations
(3.125-100
µg/mL)
mimicking
realistic
conditions,
transformed
foci
formation
was
evaluated
after
21
days.
Furthermore,
cellular
internalization
mRNA
expression
seven
genes
previously
recognized
part
predictive
early
signature
also
evaluated.
Despite
being
internalized,
none
particles
able
initiate
promote
transformation,
regardless
doping
nanomaterials.
Alternatively,
all
significantly
increased
decreased
Prl2c3
Timp4,
respectively,
under
promotion
indicating
changes
that
occur
before
foci.
These
findings
suggest
test
could
have
tumorigenic
despite
not
showing
morphological
cells.
Journal of Hazardous Materials,
Journal Year:
2025,
Volume and Issue:
493, P. 138359 - 138359
Published: April 21, 2025
This
study
examines
the
long-term
impact
of
polyethylene
terephthalate
nanoplastics
(PET-NPLs)
and
cigarette
smoke
condensate
(CSC)
on
human
lung
BEAS-2B
cells,
focusing
key
biological
hallmarks
carcinogenesis.
True-to-life
PET-NPLs
were
generated
from
plastic
water
bottles
characterized
to
simulate
environmental
exposure
conditions;
a
comprehensive
battery
assays
was
employed
assess
genotoxicity,
cellular
transformation,
invasiveness.
It
observed
that,
compared
passage
control
individual
exposures,
co-exposure
CSC
exacerbates
oxidative
stress,
tumorigenic
as
evidenced
by
increased
DNA
damage,
colony
formation
in
soft
agar,
enhanced
cell
migration
invasion.
Transcriptomic
analysis
revealed
shift
stress
regulation
including
upregulation
stress-response
genes,
SLC7A11,
NQO1,
HSPA1A,
which
are
linked
adaptation
tumor
survival.
At
same
time,
tumor-suppressor
such
LOX,
FN1,
significantly
downregulated,
promoting
transformation
These
results
provide
compelling
evidence
that
combination
enhances
carcinogenic
traits
through
genomic
instability,
disruption
tumor-suppressive
pathways.
underscores
importance
evaluating
synergistic
effects
combined
exposures
their
implications
for
health.
Toxics,
Journal Year:
2024,
Volume and Issue:
12(8), P. 553 - 553
Published: July 30, 2024
Micro/nanoplastics
(MNPs),
as
emerging
pollutants,
have
been
detected
in
both
the
maternal
and
fetal
sides
of
placenta
pregnant
women,
their
reproductive
toxicity
has
demonstrated
vivo
vitro
experimental
models.
The
Targeted
Risk
Assessment
Environmental
Chemicals
(TRAEC)
strategy
innovatively
devised
to
facilitate
valid
risk
assessment,
encompassing
a
comprehensive
evaluation
reliability,
correlation,
outcome
fitness,
integrity
across
four
dimensions
based
on
included
published
evidence
our
own
findings.
This
study
serves
an
application
case
TRAEC,
with
40
items
research
MNPs
placenta,
which
were
rigorously
screened
incorporated
into
final
scoring
system.
score
for
this
TRAEC
is
5.63,
suggesting
moderate-to-low
associated
may
potentially
increase
decreasing
particle
size.
It
essential
emphasize
that
findings
also
report
original
data
from
assays
indicating
exposure
high-dose
groups
(100
μg/mL,
200
μg/mL)
50
nm
polystyrene
nanoplastics
(PS-NPs)
induces
HTR8/SVneo
cell
cycle
arrest
apoptosis,
lead
by
disrupting
mitochondrial
function.
Overall,
employed
provide
insight
potential
health
effects
ubiquitous
MNPs.
Chemosphere,
Journal Year:
2024,
Volume and Issue:
368, P. 143702 - 143702
Published: Nov. 1, 2024
Inhalation
is
one
of
the
main
exposure
routes
to
nanoplastics.
Knowledge
toxicological
impact
nanoplastics
on
airway-
and
lung
epithelium
limited
almost
exclusively
based
submerged
in
vitro
models
using
spherical
polystyrene
(PS)
particles.
The Science of The Total Environment,
Journal Year:
2024,
Volume and Issue:
947, P. 174609 - 174609
Published: July 10, 2024
This
work
presents
the
changing
abundance
of
surface
functional
groups
(SFGs)
on
polystyrene
(PS)
upon
weathering
within
one
or
a
few
molecular
monolayers
from
point
view.
PS
particles
were
aged
by
exposing
it
to
gas
flow
typically
(5
%)
O
Advances in environmental engineering and green technologies book series,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 26
Published: Sept. 25, 2024
Micro/nanoplastic
pollution
is,
without
a
doubt,
one
of
the
most
acute
and
daunting
environmental
problems
worldwide.
This
chapter,
therefore,
uses
comprehensive
bibliometric
analysis
as
method
to
present
research
status
micro/nanoplastic
pollution.
With
respect
broader
aspects,
first,
data
are
collected
from
Scopus
database.
Therefore,
advanced
methodologies
used
detect
publication
patterns
citation
fronts.
The
results
show
that
number
publications
has
tended
increase
in
recent
years,
them
about
marine
problems.
Second,
according
thematic
available
publications,
focus
should
be
on
areas
such
sources
micro/nanopolluction,
distribution,
ecological
damage
determination,
further
expansion.
Importantly,
few
networks
identified,
they
easy
recognize
relation
concerned.
Finally,
it
becomes
clear
is
global,
not
only
local,
almost
limited
country.
