The efficacy of herbal medicines on the length of stay and negative conversion time/rate outcomes in patients with COVID-19: a systematic review

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 30, 2024

Introduction In recent years, diverse initiatives have been carried out to control the COVID-19 pandemic, ranging from measures restricting social activities analyzing drugs and vaccines. Studies on herbal medicines are also increasingly conducted in various countries as an adjuvant therapy or supplement. Therefore, this systematic review aimed investigate efficacy of analyzed through clinical trials with randomized controlled trial method. The outcomes Length Stay (LOS), Negative Conversion Time (NCT), Rate (NCR) were main focus. Methods An extensive literature spanning 2019 2023 was using well-known databases including PubMed, Scopus, Cochrane. search included relevant keywords such “randomized trial,” “COVID-19,” “herbal medicine.” Results A total 8 articles part inclusion criteria LOS, NCT, NCR. terms LOS outcomes, all types showed significant results, Persian Medicine Herbal (PM Herbal), Barley Water (PBW), Jingyin Granules (JY granules), Reduning Injection, Phyllanthus emblica (Amla). However, only JY granules results NCR outcome, while Injection reducing NCT. Conclusion These findings enrich our understanding potential benefits influencing NCT parameters patients. worked treat antiviral, anti-inflammatory, immunomodulatory mechanisms.

Language: Английский

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From Archipelago to Pandemic Battleground: Unveiling Indonesia’s COVID-19 Crisis

Journal of Epidemiology and Global Health, Journal Year: 2023, Volume and Issue: 13(4), P. 591 - 603

Published: Sept. 14, 2023

Abstract The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to countries worldwide, including Indonesia. With its unique archipelagic geography consisting of more than 17,000 thousand islands, Indonesia faces complexities in managing the spread virus. Based on existing literature, this review article elaborates key issues that have shaped Indonesia’s COVID-19 response. begins by examining early stages Indonesia, along with implementation various preventive measures and impact virus public health. This examines how socio-economic factors generally influenced healthcare system further delves into response strategies implemented Indonesian government health authorities as well overall crisis preparedness. It discusses actions taken control virus, testing vaccination efforts. difficulties encountered implementing these are presented. In conclusion, provides a comprehensive understanding covering facts multiple dimensions ranging from timeline efforts, epidemiology, implications, strategies, mobility patterns, holidays, working home, utilization complementary alternative medicine addition standard care for COVID-19. insights gained can complement future management other facing similar challenges.

Language: Английский

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The methodological reporting quality in strictly randomized controlled trials for COVID-19 and precise reporting of Chinese herbal medicine formula intervention

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 31, 2025

Chinese herbal medicine (CHM) formulas played an important role during the pandemic of coronavirus disease 2019 (COVID-19). Many randomized controlled trials (RCTs) on CHM for COVID-19 were quickly published. Concerns have been raised about their quality. In addition, inadequate detailed information formula intervention may arouse suspicion effectiveness. We aim to assess most recent evidence methodological reporting quality these RCTs with strict randomization, and precise intervention. searched from nine databases. The CONSORT 2010, CONSORT-CHM Formulas 2017, risk bias guidelines used included RCTs. checklist sub-questions based 2017 was evaluate A comparison made between that enrolled participants after first wave (defined here as December March 2020). average score 66 studies evaluated three guidelines, is 16.4, 15.2, 17.2, respectively. rate sample size calculation, allocation concealment, blinding less than 30%. can help report more precisely. Most assessed "unclear bias" due insufficient information. published in English recruited subjects a higher participant (P < 0.05). strictly inadequate-the need improve especially. worse pandemic.

Language: Английский

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Therapeutic and palliative role of a Unani herbal decoction in COVID-19 and similar respiratory viral illnesses: Phytochemical & pharmacological perspective

Journal of Ethnopharmacology, Journal Year: 2022, Volume and Issue: 297, P. 115526 - 115526

Published: July 14, 2022

Language: Английский

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The effects of acute hydrogen peroxide exposure on respiratory cilia motility and viability

PeerJ, Journal Year: 2023, Volume and Issue: 11, P. e14899 - e14899

Published: Feb. 27, 2023

COVID-19 has seen the propagation of alternative remedies to treat respiratory disease, such as nebulization hydrogen peroxide (H 2 O ). As H known cytotoxicity, it was hypothesised that inhalation would negatively impact cilia function. To test this hypothesis, mouse tracheal samples were incubated with different concentrations (0.1–1%) then motility, generated flow, and cell death assessed 0–120 min following treatment. 0.1–0.2% caused immediate depression motility complete cessation flow. Higher (≥0.5%) Cilia flow restored 30 after 0.1% remained depressed 120 0.2–0.5% No recovery treatment ≥1% . Live/dead staining revealed preferential ciliated epithelia over non-ciliated epithelia, 1% causing 35.3 ± 7.0% cells die initial This study shows significantly impacts characterised by a significant impairment in even at low concentrations, higher doses, cytotoxic effect on epithelial promoting death. While data needs further using vivo models, suggests extreme care should be taken when considering treating diseases nebulised

Language: Английский

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Complementary and alternative medicine for long COVID: a systematic review of randomized controlled trials

Therapeutic Advances in Chronic Disease, Journal Year: 2023, Volume and Issue: 14

Published: Jan. 1, 2023

Complementary and alternative medicine (CAM) interventions are growing in popularity as possible treatments for long COVID symptoms. However, comprehensive analysis of current evidence this setting is still lacking.

Language: Английский

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Use of traditional and complementary medicine for COVID 19 prophylaxis among healthcare professionals and students in Jordan: A cross-sectional study

PLoS ONE, Journal Year: 2022, Volume and Issue: 17(10), P. e0276015 - e0276015

Published: Oct. 20, 2022

There is inadequate evidence to recommend the use of any traditional and complementary medicine (T&CM) methods such as vitamin, mineral, herbal or other dietary supplements prevent treat COVID 19. Members medical team are particularly at risk exposure high viral load coronavirus. They have also best access professional information regarding disease treatment prophylaxis disseminate knowledge. The aim study was assess prevalence T&CM for 19 among healthcare professionals students in Jordan, along with most common types factors associated use.A cross-sectional conducted Jordan using a snowball sampling method distribute Google Forms enrol participants during coronavirus outbreak between June 10, 2021, August 28, 2021. included who consented participate survey. survey excluded those had filled questionnaire least once were pregnant/breast-feeding time study. consisted 29 items, including screening, checkbox, dichotomous, matrix open-ended questions.The response rate 97.1%. Out 560 respondents, 359 (64.1%) reported prevention. Vitamins nutrients consumed by almost half (48.4%) participants, while nonpharmacological remedies 35.2% 25.2%, respectively. source scientific publications (59.5%), followed guidelines (38.0%) social media (32.3%). Adverse effects 8.5% possible adverse another participants. working contact patients (OR: 1.625 (95% CI 1.047-2.523) (P = 0.03) having colleague 1.720 1.026-2.883) 0.04).The prevention high, significant proportion reporting effects. an urgent need further research toward efficacy safety well development appropriate public health policy on this issue specific each country.

Language: Английский

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Attitudes and beliefs regarding the use of herbs and supplementary medications with COVID-19: A systematic review

Research in Social and Administrative Pharmacy, Journal Year: 2022, Volume and Issue: 19(3), P. 343 - 355

Published: Nov. 13, 2022

Language: Английский

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Combination of Chinese herbal medicine and conventional western medicine for coronavirus disease 2019: a systematic review and meta-analysis

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: July 17, 2023

This study aimed to assess the efficacy and safety of Chinese herbal medicine (CHM) plus conventional western (CWM) in comparison with CWM against COVID-19.We searched eight electronic databases three trial registers spanning from January 1, 2020 May 18, 2023. We included randomized controlled trials (RCTs) comparing effectiveness CHM COVID-19 our study. The Cochrane Risk Bias tool 2.0 (RoB2) was applied evaluate methodological quality RCTs. Grading Recommendations, Assessment, Development, Evaluation (GRADE) system employed certainty evidence. Statistical analysis implemented R version 4.1.2.Our 50 RCTs involving 11,624 patients. In sole CWM, significantly enhanced clinical effective rate (RR = 1.18, 95% CI [1.13, 1.22]), improved chest image 1.19, [1.11, 1.28]), inhibited deterioration 0.45, [0.33, 0.60]), lowered mortality 0.53, [0.40, 0.70]), reduced total score TCM syndrome (SMD -1.24, [-1.82, -0.66]). SARS-CoV-2 nucleic acid conversion time (MD -2.66, [-3.88, -1.44]), duration hospitalization -2.36, [-3.89, -0.82]), symptom (fever, cough, fatigue, shortness breath) recovery times were shorter groups than groups. Further, treatment more conducive for some laboratory indicators returning normal levels. No statistical difference found incidence adverse reactions between two 0.97, [0.88, 1.07]). assessed risk bias 246 outcomes, categorized 55 into "low risk", 151 "some concerns", 40 "high risk". Overall, evidence ranged moderate very low.Potentially, listed this study, as an adjunctive therapy, combining is safe therapy mode COVID-19. However, high-quality are needed draw accurate conclusions.https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=293963.

Language: Английский

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Curative Potential of High-Value Phytochemicals on COVID-19 Infection

Biochemistry (Moscow), Journal Year: 2023, Volume and Issue: 88(1), P. 64 - 72

Published: Jan. 1, 2023

Language: Английский

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