Medicine,
Journal Year:
2025,
Volume and Issue:
104(7), P. e41550 - e41550
Published: Feb. 14, 2025
Background:
To
systematically
evaluate
the
effectiveness
of
regular
coffee
intake
in
prevention
or
treatment
COVID-19
infection,
and
to
explore
its
possible
mechanism
action
using
computer
molecular
docking
technology.
Methods:
We
searched
for
relevant
ClinicalTrials.gov,
Cochrane
Library,
PubMed,
Web
Science,
Embase,
China
Biomedicine,
Wanfang,
CNKI,
VIP
databases
summarize
studies
on
preventing
treating
COVID-19.
The
search
period
lasted
until
August
1,
2024.
2
researchers
screened
literature
data
Rev
Man
5.4
software
(the
Collaboration,
2020)
analysis
used
Schrodinger
2018-1
mechanisms
action.
Results:
A
total
5
with
39,290
participants
were
included.
results
showed
that
compared
control
group
drank
less
no
coffee,
experimental
more
than
1
cup
per
day
had
significantly
higher
benefit
rates
(RD
=
0.17,
95%
confidence
intervals
[CI]
0.08–0.27,
P
.0005),
including
lower
infection
improved
recovery
from
0.24,
CI
0.13–0.35),
<
.0001).
Molecular
CGA
caffeine
present
could
combine
key
amino
acid
residues
ACE2
3CL
proteins
form
hydrogen
bonds.
Conclusions:
Regular
consumption
may
have
certain
preventive
therapeutic
effects
COVID-19,
be
or/caffeine
related
formation
bonds
by
such
as
ARG273/HIE345
CYS145
3CL.
Owing
limited
number
quality
included
studies,
effect
evaluation
needs
further
confirmed
clinical
randomized
controlled
trials.
exact
requires
verification
at
level,
both
inside
outside
cells.
Foods,
Journal Year:
2025,
Volume and Issue:
14(5), P. 745 - 745
Published: Feb. 22, 2025
Green
tea
possesses
antioxidant,
anti-inflammatory,
anticancer,
and
antimicrobial
activities,
reduces
body
weight,
slows
down
aging.
These
effects
are
primarily
attributed
to
catechins
contained
in
green
leaves,
particularly
epigallocatechin-3-gallate.
However,
humans,
the
realization
of
tea's
beneficial
is
limited.
In
order
summarize
critically
analyze
available
scientific
information
about
health
benefits
issues
related
its
use,
we
conducted
an
in-depth
literature
review
databases.
A
number
vitro
studies
reported
that
modulate
various
signaling
pathways
cells,
which
thought
underlie
their
effects.
data
on
humans
scarce,
partly
due
low
stability
oral
bioavailability.
Furthermore,
may
also
participate
pharmacokinetic
interactions
when
co-administered
with
certain
drugs
such
as
anticancer
agents,
for
cardiovascular
diseases,
immunosuppressors,
etc.
As
a
result,
adverse
drug
reactions
or
therapy
failure
occur.
conclusion,
over
years,
approaches
have
been
investigated
optimize
catechin
intake
achieve
but
date,
use
prophylaxis
disease
treatment
remains
Therefore,
future
regarding
possibilities
administration
needed.
Journal of Functional Foods,
Journal Year:
2022,
Volume and Issue:
96, P. 105210 - 105210
Published: Aug. 9, 2022
The
functional
beverages
(FBs)
are
an
important
segment
of
food
products
due
to
health
benefits
they
provide
and
their
appealing
sensory
characteristics,
suitability
affordability.
FBs
market
offers
many
opportunities
for
new
product
development
(nutraceuticals,
colorants,
plant-based
medicines
products)
with
desirable
effective
composition
nutrients
bioactive
molecules
(BAMs)
aimed
deliver
improve
human
well-being.
Recently,
the
use
medicinal
aromatic
plants
(MAPs)
in
production
has
become
increasingly
popular
specific
content
(amino
fatty
acids)
BAMs
(volatile
non-volatile)
attributed
biological
effects
benefits.
stored
leaves,
flowers,
fruits,
seeds,
barks
roots,
mostly
include
phenolics
(phenolic
acids,
flavonoids,
tanins,
anthocyanins,
lignans
stilbenes),
essential
oils
(EOs),
terpenoids,
alkaloids,
phytosterols
saponins.
features
MAPs
mainly
related
volatile
compounds
EOs,
but
presence
non-volatile
compounds,
such
as
phenolics,
also
contributes
properties.
Phytochemical
profiling
plant
species
containing
complex
mixtures
BAMs,
provides
numerous
categories
FBs,
opens
challenges
isolation
using
conventional
advanced
extraction
techniques,
well
determination
potential
effects.
This
review
summarizes
most
common
from
selected
effects,
techniques
suitable
extracts
quality
prediction
trends,
several
directions
towards
future
research
on
strategies.
Foods,
Journal Year:
2022,
Volume and Issue:
11(14), P. 2064 - 2064
Published: July 12, 2022
Current
estimates
place
the
amount
of
spent
coffee
grounds
annually
generated
worldwide
in
6
million
ton
figure,
with
sources
being
classified
as
domestic
(i.e.,
household),
commercial
houses,
cafeterias
and
restaurants),
industrial
soluble
instant
industries).
The
majority
produced
are
currently
inappropriately
destined
for
landfills
or
to
a
form
energy
recovery
(e.g.,
incineration)
refuse-derived
fuel.
disposal
allows
its
anaerobic
degradation
consequent
generation
emission
aggressive
greenhouse
gases
such
methane
CO2,
processes
must
be
considered
an
end-of-life
stage
lifecycle
grounds,
way
delaying
CO2
emissions
avoiding
toxic
organic
volatile
compounds
during
combustion
this
type
waste.
Aside
from
these
environmental
issues,
aspect
that
should
is
inappropriate
product
(SCG)
presents
unique
thermo-mechanical
properties
textural
characteristics
rich
diversity
classes
compounds,
polysaccharides,
proteins,
phenolics,
lipids
alkaloids,
which
could
recovered
used
applications,
including
food-related
ones.
Therefore,
researchers
invested
studying
variety
possible
applications
products
thereof,
(but
not
limited
to)
biofuels,
catalysts,
cosmetics,
composite
materials,
feed
food
ingredients.
Hence,
aim
essay
was
present
comprehensive
review
recent
literature
on
proposals
utilization
focus
chemical
composition
coffee,
bioactive
use
ingredients
components
manufacture
materials
can
packaging.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(4), P. 1379 - 1379
Published: Feb. 18, 2022
Benzo[a]pyrene
(BaP)
is
a
polycyclic
aromatic
hydrocarbon
(PAH)
primarily
formed
by
burning
of
fossil
fuels,
wood
and
other
organic
materials.
BaP
as
group
I
carcinogen
shows
mutagenic
carcinogenic
effects.
One
the
important
mechanisms
action
its
free
radical
activity,
effect
which
induction
oxidative
stress
in
cells.
induces
through
production
reactive
oxygen
species
(ROS),
disturbances
activity
antioxidant
enzymes,
reduction
level
non-enzymatic
antioxidants
well
cytokine
production.
Chemical
compounds,
such
vitamin
E,
curcumin,
quercetin,
catechin,
cyanidin,
kuromanin,
berberine,
resveratrol,
baicalein,
myricetin,
catechin
hydrate,
hesperetin,
rhaponticin,
taurine,
atorvastatin,
diallyl
sulfide,
those
contained
green
white
tea,
lower
induced
BaP.
They
regulate
expression
genes
involved
inflammation,
therefore
can
reduce
ROS.
These
substances
remove
ROS
lipid
protein
peroxidation,
formation
adducts
with
DNA,
increase
enzymatic
pro-inflammatory
cytokines.
undergo
chemical
modification
living
cells,
results
more
metabolites
formation.
Some
protective
have
ability
to
metabolism,
particular
cytochrome
(CYP
P450),
reduces
metabolites,
decreases
The
aim
this
review
discuss
properties
BaP,
describe
activities
selected
chemicals
against
based
on
latest
publications.
Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
11
Published: Jan. 4, 2024
Polyphenolic
compounds
constitute
a
diverse
group
of
natural
components
commonly
occurring
in
various
plant
species,
known
for
their
potential
to
exert
both
beneficial
and
detrimental
effects.
Additionally,
these
polyphenols
have
also
been
implicated
as
endocrine-disrupting
(ED)
chemicals,
raising
concerns
about
widespread
use
the
cosmetics
industry.
In
this
comprehensive
review,
we
focus
on
body
literature
pertaining
estrogenic
properties
ED
with
particular
emphasis
interaction
isoflavones
estrogen
receptors.
Within
aim
elucidate
multifaceted
roles
effects
skin,
exploring
benefits
well
capacity
act
agents.
By
delving
into
intricate
subject
matter,
intend
provoke
thoughtful
consideration,
effectively
opening
Pandora’s
box
questions
reader
ponder.
Ultimately,
invite
contemplate
whether
should
be
regarded
friends
or
foes
realm
skincare
endocrine
disruption.
Nutrients,
Journal Year:
2022,
Volume and Issue:
14(15), P. 3099 - 3099
Published: July 28, 2022
Major
Depressive
Disorder
(MDD)
is
a
growing
disabling
condition
affecting
around
280
million
people
worldwide.
This
complex
entity
the
result
of
interplay
between
biological,
psychological,
and
sociocultural
factors,
compelling
evidence
suggests
that
MDD
can
be
considered
disease
occurs
as
consequence
an
evolutionary
mismatch
unhealthy
lifestyle
habits.
In
this
context,
diet
one
core
pillars
health,
influencing
multiple
biological
processes
in
brain
entire
body.
It
seems
there
bidirectional
relationship
malnutrition,
depressed
individuals
often
lack
certain
critical
nutrients
along
with
aberrant
dietary
pattern.
Thus,
interventions
are
most
promising
tools
to
explore
field
MDD,
specific
group
(i.e.,
omega
3,
vitamins,
polyphenols,
caffeine),
foods
(fish,
nuts,
seeds
fruits,
vegetables,
coffee/tea,
fermented
products)
or
supplements
(such
S-adenosylmethionine,
acetyl
carnitine,
creatine,
amino
acids,
etc.),
which
being
currently
studied.
Likewise,
nutritional
context
pattern
seem
another
potential
area
study,
some
strategies
such
Mediterranean
have
demonstrated
relevant
benefits
patients
MDD;
although,
further
efforts
still
needed.
present
work,
we
will
state-of-the-art
prevention
clinical
support
focusing
on
properties
its
main
nutrients,
foods,
patterns
their
possible
implications
for
these
patients.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(16), P. 5126 - 5126
Published: Aug. 11, 2022
Coffee
is
the
most
widely
used
beverage
globally
and
contains
many
bioactive
compounds,
including
phenolic
alkaloids,
triterpenes,
organic
acids,
amino
hormones,
fatty
acids.
The
main
objective
of
this
study
was
comparative
profiling
Australian,
Colombian,
Ethiopian,
Peruvian
C.
arabica
using
LC-ESI-QTOF-MS/MS.
In
study,
we
tentatively
identified
136
metabolites,
five
(05)
six
(06)
three
(03)
acids
(l-phenylalanine,
l-tyrosine,
l-pyroglutamic
acid),
two
(02)
hormones
(melatonin
serotonin),
one
(01)
furopyrans
(goniothalenol),
carotenoid
(crocetin),
terpenoids,
thirty-eight
(38)
forty-one
(41)
flavonoids,
stilbenes,
lignans
twenty-three
(23)
other
polyphenols
in
arabica.
highest
TPC
value
(17.74
±
0.32
mg
GAE/g)
measured
Colombian
coffee
while
lowest
(10.24
0.73
coffee.
has
a
higher
antioxidant
potential
than
studied
samples.
A
total
nineteen
metabolites
were
mapped
through
LC-MS/MS.
Quinic
acid
derivatives
quantified
concentrations
metabolites.
Furthermore,
molecular
docking
predicted
that
chlorogenic
compound
contributes
to
anti-Alzheimer
anti-diabetic
activities
obtained
results
indicate
vast
number
compounds
which
have
health
benefits.
research
could
be
conducted
validate
effect
these
on
flavor
profile
beverages.