Beneficial effects and possible mechanism of intake coffee for COVID-19: A meta-analysis and molecular docking DOI Creative Commons
Yong-Zheng Fan,

Yun-Li Duan,

Ao Zhang

et al.

Medicine, Journal Year: 2025, Volume and Issue: 104(7), P. e41550 - e41550

Published: Feb. 14, 2025

Background: To systematically evaluate the effectiveness of regular coffee intake in prevention or treatment COVID-19 infection, and to explore its possible mechanism action using computer molecular docking technology. Methods: We searched for relevant ClinicalTrials.gov, Cochrane Library, PubMed, Web Science, Embase, China Biomedicine, Wanfang, CNKI, VIP databases summarize studies on preventing treating COVID-19. The search period lasted until August 1, 2024. 2 researchers screened literature data Rev Man 5.4 software (the Collaboration, 2020) analysis used Schrodinger 2018-1 mechanisms action. Results: A total 5 with 39,290 participants were included. results showed that compared control group drank less no coffee, experimental more than 1 cup per day had significantly higher benefit rates (RD = 0.17, 95% confidence intervals [CI] 0.08–0.27, P .0005), including lower infection improved recovery from 0.24, CI 0.13–0.35), < .0001). Molecular CGA caffeine present could combine key amino acid residues ACE2 3CL proteins form hydrogen bonds. Conclusions: Regular consumption may have certain preventive therapeutic effects COVID-19, be or/caffeine related formation bonds by such as ARG273/HIE345 CYS145 3CL. Owing limited number quality included studies, effect evaluation needs further confirmed clinical randomized controlled trials. exact requires verification at level, both inside outside cells.

Language: Английский

Green Tea: Current Knowledge and Issues DOI Creative Commons
Maya Radeva–Ilieva, Stanila Stoeva, Nadezhda Hvarchanova

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(5), P. 745 - 745

Published: Feb. 22, 2025

Green tea possesses antioxidant, anti-inflammatory, anticancer, and antimicrobial activities, reduces body weight, slows down aging. These effects are primarily attributed to catechins contained in green leaves, particularly epigallocatechin-3-gallate. However, humans, the realization of tea's beneficial is limited. In order summarize critically analyze available scientific information about health benefits issues related its use, we conducted an in-depth literature review databases. A number vitro studies reported that modulate various signaling pathways cells, which thought underlie their effects. data on humans scarce, partly due low stability oral bioavailability. Furthermore, may also participate pharmacokinetic interactions when co-administered with certain drugs such as anticancer agents, for cardiovascular diseases, immunosuppressors, etc. As a result, adverse drug reactions or therapy failure occur. conclusion, over years, approaches have been investigated optimize catechin intake achieve but date, use prophylaxis disease treatment remains Therefore, future regarding possibilities administration needed.

Language: Английский

Citations

2

The medicinal and aromatic plants as ingredients in functional beverage production DOI Creative Commons
Ivanka Maleš, Sandra Pedišić, Zoran Zorić

et al.

Journal of Functional Foods, Journal Year: 2022, Volume and Issue: 96, P. 105210 - 105210

Published: Aug. 9, 2022

The functional beverages (FBs) are an important segment of food products due to health benefits they provide and their appealing sensory characteristics, suitability affordability. FBs market offers many opportunities for new product development (nutraceuticals, colorants, plant-based medicines products) with desirable effective composition nutrients bioactive molecules (BAMs) aimed deliver improve human well-being. Recently, the use medicinal aromatic plants (MAPs) in production has become increasingly popular specific content (amino fatty acids) BAMs (volatile non-volatile) attributed biological effects benefits. stored leaves, flowers, fruits, seeds, barks roots, mostly include phenolics (phenolic acids, flavonoids, tanins, anthocyanins, lignans stilbenes), essential oils (EOs), terpenoids, alkaloids, phytosterols saponins. features MAPs mainly related volatile compounds EOs, but presence non-volatile compounds, such as phenolics, also contributes properties. Phytochemical profiling plant species containing complex mixtures BAMs, provides numerous categories FBs, opens challenges isolation using conventional advanced extraction techniques, well determination potential effects. This review summarizes most common from selected effects, techniques suitable extracts quality prediction trends, several directions towards future research on strategies.

Language: Английский

Citations

67

Potential Uses of Spent Coffee Grounds in the Food Industry DOI Creative Commons
Adriana S. Franca, Leandro S. Oliveira

Foods, Journal Year: 2022, Volume and Issue: 11(14), P. 2064 - 2064

Published: July 12, 2022

Current estimates place the amount of spent coffee grounds annually generated worldwide in 6 million ton figure, with sources being classified as domestic (i.e., household), commercial houses, cafeterias and restaurants), industrial soluble instant industries). The majority produced are currently inappropriately destined for landfills or to a form energy recovery (e.g., incineration) refuse-derived fuel. disposal allows its anaerobic degradation consequent generation emission aggressive greenhouse gases such methane CO2, processes must be considered an end-of-life stage lifecycle grounds, way delaying CO2 emissions avoiding toxic organic volatile compounds during combustion this type waste. Aside from these environmental issues, aspect that should is inappropriate product (SCG) presents unique thermo-mechanical properties textural characteristics rich diversity classes compounds, polysaccharides, proteins, phenolics, lipids alkaloids, which could recovered used applications, including food-related ones. Therefore, researchers invested studying variety possible applications products thereof, (but not limited to) biofuels, catalysts, cosmetics, composite materials, feed food ingredients. Hence, aim essay was present comprehensive review recent literature on proposals utilization focus chemical composition coffee, bioactive use ingredients components manufacture materials can packaging.

Language: Английский

Citations

58

Molecular Mechanisms of Action of Selected Substances Involved in the Reduction of Benzo[a]pyrene-Induced Oxidative Stress DOI Creative Commons
Bożena Bukowska, Piotr Duchnowicz

Molecules, Journal Year: 2022, Volume and Issue: 27(4), P. 1379 - 1379

Published: Feb. 18, 2022

Benzo[a]pyrene (BaP) is a polycyclic aromatic hydrocarbon (PAH) primarily formed by burning of fossil fuels, wood and other organic materials. BaP as group I carcinogen shows mutagenic carcinogenic effects. One the important mechanisms action its free radical activity, effect which induction oxidative stress in cells. induces through production reactive oxygen species (ROS), disturbances activity antioxidant enzymes, reduction level non-enzymatic antioxidants well cytokine production. Chemical compounds, such vitamin E, curcumin, quercetin, catechin, cyanidin, kuromanin, berberine, resveratrol, baicalein, myricetin, catechin hydrate, hesperetin, rhaponticin, taurine, atorvastatin, diallyl sulfide, those contained green white tea, lower induced BaP. They regulate expression genes involved inflammation, therefore can reduce ROS. These substances remove ROS lipid protein peroxidation, formation adducts with DNA, increase enzymatic pro-inflammatory cytokines. undergo chemical modification living cells, results more metabolites formation. Some protective have ability to metabolism, particular cytochrome (CYP P450), reduces metabolites, decreases The aim this review discuss properties BaP, describe activities selected chemicals against based on latest publications.

Language: Английский

Citations

47

Epigallocatechin-3-Gallate (EGCG): A unique secondary metabolite with diverse roles in plant-environment interaction DOI
Golam Jalal Ahammed,

Yaxian Wu,

Yameng Wang

et al.

Environmental and Experimental Botany, Journal Year: 2023, Volume and Issue: 209, P. 105299 - 105299

Published: March 17, 2023

Language: Английский

Citations

24

Neurotoxicity of ochratoxin A: Molecular mechanisms and neurotherapeutic strategies DOI

Blessing A. Obafemi,

Isaac A. Adedara, João Batista Teixeira da Rocha

et al.

Toxicology, Journal Year: 2023, Volume and Issue: 497-498, P. 153630 - 153630

Published: Sept. 13, 2023

Language: Английский

Citations

24

An extensive review on phenolic compounds and their potential estrogenic properties on skin physiology DOI Creative Commons

Francesca Rispo,

Giulia De Negri Atanasio,

Ilaria Demori

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 4, 2024

Polyphenolic compounds constitute a diverse group of natural components commonly occurring in various plant species, known for their potential to exert both beneficial and detrimental effects. Additionally, these polyphenols have also been implicated as endocrine-disrupting (ED) chemicals, raising concerns about widespread use the cosmetics industry. In this comprehensive review, we focus on body literature pertaining estrogenic properties ED with particular emphasis interaction isoflavones estrogen receptors. Within aim elucidate multifaceted roles effects skin, exploring benefits well capacity act agents. By delving into intricate subject matter, intend provoke thoughtful consideration, effectively opening Pandora’s box questions reader ponder. Ultimately, invite contemplate whether should be regarded friends or foes realm skincare endocrine disruption.

Language: Английский

Citations

9

Biological Role of Nutrients, Food and Dietary Patterns in the Prevention and Clinical Management of Major Depressive Disorder DOI Open Access
Miguel Á. Ortega, Oscar Fraile‐Martínez, Cielo García‐Montero

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(15), P. 3099 - 3099

Published: July 28, 2022

Major Depressive Disorder (MDD) is a growing disabling condition affecting around 280 million people worldwide. This complex entity the result of interplay between biological, psychological, and sociocultural factors, compelling evidence suggests that MDD can be considered disease occurs as consequence an evolutionary mismatch unhealthy lifestyle habits. In this context, diet one core pillars health, influencing multiple biological processes in brain entire body. It seems there bidirectional relationship malnutrition, depressed individuals often lack certain critical nutrients along with aberrant dietary pattern. Thus, interventions are most promising tools to explore field MDD, specific group (i.e., omega 3, vitamins, polyphenols, caffeine), foods (fish, nuts, seeds fruits, vegetables, coffee/tea, fermented products) or supplements (such S-adenosylmethionine, acetyl carnitine, creatine, amino acids, etc.), which being currently studied. Likewise, nutritional context pattern seem another potential area study, some strategies such Mediterranean have demonstrated relevant benefits patients MDD; although, further efforts still needed. present work, we will state-of-the-art prevention clinical support focusing on properties its main nutrients, foods, patterns their possible implications for these patients.

Language: Английский

Citations

37

A Comparative Study for Nutritional and Phytochemical Profiling of Coffea arabica (C. arabica) from Different Origins and Their Antioxidant Potential and Molecular Docking DOI Creative Commons
Akhtar Ali, Hafza Fasiha Zahid, Jeremy J. Cottrell

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(16), P. 5126 - 5126

Published: Aug. 11, 2022

Coffee is the most widely used beverage globally and contains many bioactive compounds, including phenolic alkaloids, triterpenes, organic acids, amino hormones, fatty acids. The main objective of this study was comparative profiling Australian, Colombian, Ethiopian, Peruvian C. arabica using LC-ESI-QTOF-MS/MS. In study, we tentatively identified 136 metabolites, five (05) six (06) three (03) acids (l-phenylalanine, l-tyrosine, l-pyroglutamic acid), two (02) hormones (melatonin serotonin), one (01) furopyrans (goniothalenol), carotenoid (crocetin), terpenoids, thirty-eight (38) forty-one (41) flavonoids, stilbenes, lignans twenty-three (23) other polyphenols in arabica. highest TPC value (17.74 ± 0.32 mg GAE/g) measured Colombian coffee while lowest (10.24 0.73 coffee. has a higher antioxidant potential than studied samples. A total nineteen metabolites were mapped through LC-MS/MS. Quinic acid derivatives quantified concentrations metabolites. Furthermore, molecular docking predicted that chlorogenic compound contributes to anti-Alzheimer anti-diabetic activities obtained results indicate vast number compounds which have health benefits. research could be conducted validate effect these on flavor profile beverages.

Language: Английский

Citations

35

Hormonal regulation of health-promoting compounds in tea (Camellia sinensis L.) DOI
Golam Jalal Ahammed, Xin Li

Plant Physiology and Biochemistry, Journal Year: 2022, Volume and Issue: 185, P. 390 - 400

Published: June 21, 2022

Language: Английский

Citations

30