Biofunctionalized polymeric nanoparticles for the enhanced delivery of erlotinib in cancer therapy DOI
Ruchı Tıwarı, Anasuya Patil,

Ritu Verma

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 26

Published: Nov. 23, 2024

Erlotinib, a potent epidermal growth factor receptor (EGFR) inhibitor, faces bioavailability challenges due to poor water solubility and stability. This study aims optimize erlotinib-loaded PLGA nanoparticles using 32 factorial design enhance drug delivery therapeutic efficacy. The effects of concentration (R1) NaTPP (R2) on nanoparticle characteristics, including particle size, zeta potential, polydispersity index (PDI), were investigated. optimal formulation (F5) was identified characterized, showing size 169.1 nm, potential 20.0 mV, PDI 0.146, indicating uniform stable nanoparticles. Transmission electron microscopy (TEM) confirmed spherical with minimal aggregation, while X-ray diffraction (XRD) indicated an amorphous state erlotinib. Formulation F5 demonstrated entrapment efficiency 81.9% yield 83.0%. In-vitro release studies revealed sustained pattern 90.0% cumulative at 48 h, following Zero Order kinetics. Cytotoxicity assays showed low cytotoxicity across various cell lines. Statistical analysis the significant impact variables properties. systematic optimization has successfully as candidate favorable high stability, controlled release, safe profile. Notably, optimized enhances efficacy through improved targeted delivery, addressing limitations conventional therapies. These findings suggest that hold for enhanced

Language: Английский

Polymeric and non-polymeric oxaliplatin nanomedicine for cancer therapy: A comprehensive review DOI
Mehrab Pourmadadi,

Meysam Shaghaghi,

Rabia Arshad

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: 208, P. 112870 - 112870

Published: Feb. 23, 2024

Language: Английский

Citations

11
Cerium Oxide Nanoparticles and Their Polymeric Composites: Advancements in Biomedical Applications DOI
Satheesh Selvaraj, Ankush Chauhan, Arunkumar Radhakrishnan

et al.

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 27, 2024

Language: Английский

Citations

11
On QSPR analysis of pulmonary cancer drugs using python-driven topological modeling DOI Creative Commons

Huiling Qin,

Mazhar Hussain, Muhammad Farhan Hanif

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 1, 2025

Language: Английский

Citations

1
A computer-aided, heterodimer-based “triadic” carrier-free drug delivery platform to mitigate multidrug resistance in lung cancer and enhance efficiency DOI
Liyan Yang, Yingying Zhang,

Yuxin Lai

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 677, P. 523 - 540

Published: Aug. 14, 2024

Language: Английский

Citations

7
A comprehensive perspective of trastuzumab-based delivery systems for breast cancer treatment DOI

Arezoo Gholami,

Hamidreza Abdouss, Mehrab Pourmadadi

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 95, P. 105592 - 105592

Published: March 16, 2024

Language: Английский

Citations

6
The Construction of Polyethylene Glycol‐Folic Acid Modified Magnetic Layered Hydroxide Nanoplatform for Controlled Drug Delivery DOI
Mengyuan Li,

Jinling Guo,

Jiaming Ge

et al.

Journal of Applied Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: May 3, 2025

ABSTRACT The application prospects of magnetic nanocomposites in cancer treatment and diagnosis are extensive, as they enable targeted drug delivery to tumors. Herein, a novel therapeutic strategy was proposed for oral squamous cell carcinoma (OSCC), which polyethylene glycol‐folic acid (FA‐PEG) modified on by combining Fe 3 O 4 layered double hydroxide (LDH) obtain carrier the anticancer berberine (Ber). We have confirmed that FA‐PEG/Fe @LDH exhibited high loading capacity Ber excellent biocompatibility. Moreover, it demonstrated remarkable pH‐responsive release (Ber 3.87% 53.77% within 48 h at pH 7.4 5.0, respectively). cellular experiments @LDH@Ber significant inhibition activity, while effectively depleted overexpressed GSH promoted ROS generation, thereby facilitating oxidative stress inducing mitochondrial dysfunction CAL27 cells, thus promoting apoptosis cells. Therefore, can be used potential pH‐controlled system has great significance therapy OSCC.

Language: Английский

Citations

0
Homologous-adhering/targeting cell membrane- and cell-mediated delivery systems: a cancer-catch-cancer strategy in cancer therapy DOI Creative Commons
Chenguang Liu, Jingjie Gao, Yuying Cheng

et al.

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 12

Published: Nov. 20, 2024

Abstract Low tumor enrichment remains a serious and urgent problem for drug delivery in cancer therapy. Accurate targeting of sites is still critical aim Though there have been variety strategies to improve the enrichment, biological barriers cause most delivered guests fail or be excreted before they work. Recently, cell membrane-based systems attracted huge amount attention due their advantages such as easy access, good biocompatibility immune escape, which contribute biomimetic structures specific surface proteins. Furthermore, are referred homologous-targeting function exhibit significantly high adhesion internalization homologous-type cells even though exact mechanism not entirely revealed. Here, we summarize sources characterizations membrane systems, including reconstructed single hybrid nano-/microcarriers, well engineered cells. Additionally, advanced applications these therapy categorized summarized according components membranes. The potential factors related homologous also discussed. By discussing applications, challenges opportunities, expect far-reaching development preclinic clinics.

Language: Английский

Citations

3
The smart nanocarrier containing zein/starch co-biopolymers enhanced by graphitic carbon nitride; exploring opportunities in brain cancer treatment DOI
Mehrab Pourmadadi,

Pegah Poorkhalili,

Maral Sorourian

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 274, P. 133275 - 133275

Published: June 19, 2024

Language: Английский

Citations

2
Nanotechnology in Glioblastoma Therapy: Advances in Drug Delivery Systems and Diagnostic Approaches DOI Creative Commons

Maimoona Qindeel,

Mahnoor Irfan,

Sami Ullah

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 102, P. 106322 - 106322

Published: Oct. 24, 2024

Language: Английский

Citations

2
Biofunctionalized polymeric nanoparticles for the enhanced delivery of erlotinib in cancer therapy DOI
Ruchı Tıwarı, Anasuya Patil,

Ritu Verma

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 26

Published: Nov. 23, 2024

Erlotinib, a potent epidermal growth factor receptor (EGFR) inhibitor, faces bioavailability challenges due to poor water solubility and stability. This study aims optimize erlotinib-loaded PLGA nanoparticles using 32 factorial design enhance drug delivery therapeutic efficacy. The effects of concentration (R1) NaTPP (R2) on nanoparticle characteristics, including particle size, zeta potential, polydispersity index (PDI), were investigated. optimal formulation (F5) was identified characterized, showing size 169.1 nm, potential 20.0 mV, PDI 0.146, indicating uniform stable nanoparticles. Transmission electron microscopy (TEM) confirmed spherical with minimal aggregation, while X-ray diffraction (XRD) indicated an amorphous state erlotinib. Formulation F5 demonstrated entrapment efficiency 81.9% yield 83.0%. In-vitro release studies revealed sustained pattern 90.0% cumulative at 48 h, following Zero Order kinetics. Cytotoxicity assays showed low cytotoxicity across various cell lines. Statistical analysis the significant impact variables properties. systematic optimization has successfully as candidate favorable high stability, controlled release, safe profile. Notably, optimized enhances efficacy through improved targeted delivery, addressing limitations conventional therapies. These findings suggest that hold for enhanced

Language: Английский

Citations

0