Jurnal Kimia Sains dan Aplikasi,
Journal Year:
2024,
Volume and Issue:
27(10), P. 464 - 469
Published: Sept. 23, 2024
The
issue
of
antibiotic
resistance
by
bacteria
has
been
studied
to
develop
a
new
agent
inhibit
bacterial
activity.
Recent
studies
have
reported
on
nanoparticles
promising
antibacterial
properties.
Zirconium
dioxide
(ZrO2
NPs)
emerged
as
potential
agents
for
gram-negative
bacteria.
Nevertheless,
there
remains
gap
in
research
done
producing
stable
nanoparticles.
Additionally,
it
the
impact
liquid
environment
synthesis
keep
small
size.
In
this
present
work,
ZrO2
NPs
successfully
synthesized
various
liquids
pulse
laser
ablation
using
Nd:YAG
laser.
was
ablated
surface
zirconium
metal
plate
different
media,
such
deionized
water,
ethylene
diamine,
and
chitosan
solution.
Furthermore,
media
used
an
effect
characteristics
their
An
investigation
scanning
electron
microscope
images
reveals
that
solutions
spherical
morphology
with
diameters
measuring
around
24.33
nm,
19.76
15.05
respectively.
solution
against
E.
coli
is
assessed
diameter
inhibition
zone
(DIZ),
which
greater
colloidal
stability
than
other
media.
findings
indicate
size
enhance
ability
growth
Applied Organometallic Chemistry,
Journal Year:
2025,
Volume and Issue:
39(4)
Published: March 3, 2025
ABSTRACT
Cancer
is
a
significant
global
public
health
concern,
being
the
second
leading
cause
of
mortality,
accounting
for
one
in
six
cases
worldwide.
Researchers
have
employed
various
approaches
cancer
treatment,
with
nanobiotechnology
emerging
as
standout
technique
developing
anticancer
agents.
This
study
assessed
activity
chitosan
(CS)‐coated
gold
nanoparticles
(AuNPs)
and
combination
AuNPs–papain
(Pap)–folic
acid
(FA)
nanomaterial
platforms
against
Michigan
Foundation‐7
(MCF‐7)
cell
lines.
A
range
methods,
including
ultraviolet–visible
(UV–Vis),
Fourier
transform
infrared
(FTIR),
scanning
electron
microscopy
(SEM),
transmission
(TEM),
X‐ray
diffraction
(XRD),
energy‐dispersive
spectroscopy
(EDS),
zeta
potential,
were
used
to
characterize
prepared
nanomaterials.
AuNPs
AuNPs–Pap–FA
exhibited
UV–Vis
absorption
at
525
558
nm,
respectively.
In
XRD
test,
peaks
found
32°,
39°,
45°,
65°,
78.5°,
AuNPs–CS–Pap–FA
identified
29,
37°,
78.5°.
SEM
revealed
irregularly
dispensed
oval
shapes
AuNPs.
TEM
images
confirmed
shape
before
after
coating
Pap
FA.
The
mean
diameter
was
15
AuNPs–CS–Pap–FA,
it
22.5
nm.
Acridine
orange–ethidium
bromide
(AO/EB)
staining,
flow
cytometry
assay,
2,2‐diphenyl‐1‐picrylhydrazyl
(DPPH),
vitro
hemolysis
assays
conducted.
maximum
scavenging
observed
reaching
up
90%.
hemolytic
rate
low
concentrations
(3.12,
6.25,
12.5
μg
mL
−1
)
within
permissible
levels.
concentration
100
reduced
viability
MCF‐7
cells
10%
when
compared
nontreated
cells.
highest
expression
caspase‐8
achieved
treating
line
AuNPs–CS–Pap–FA.
nanopreparation
remarkable
holds
promise
potential
candidate
further
development
towards
clinical
applications
an
agent.
