Elsevier eBooks, Journal Year: 2022, Volume and Issue: unknown, P. 313 - 338
Published: Oct. 29, 2022
Language: Английский
Journal of Infection and Public Health, Journal Year: 2022, Volume and Issue: 16(1), P. 4 - 14
Published: Nov. 19, 2022
Newly emerging variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are continuously posing high global public health concerns and panic resulting in waves disease 2019 (COVID-19) pandemic. Depending on the extent genomic variations, mutations adaptation, few gain ability to spread quickly across many countries, acquire higher virulency cause disease, morbidity mortality. These have been implicated lessening efficacy current COVID-19 vaccines immunotherapies break-through viral infections vaccinated individuals recovered patients. Altogether, these could hinder protective herd immunity be achieved through ongoing progressive vaccination. Currently, only variant interest SARS-CoV-2 is Omicron that was first identified South Africa. In this review, we present overview with a special focus variant, its lineages hybrid variants. We discuss hypotheses origin, genetic change underlying molecular mechanism behind transmissibility immune escape variant. Major related including available immunotherapeutics vaccines, transmissibility, severity, mortality discussed. last part, challenges strategies counter amid pandemic presented.
Language: Английский
Citations
206
Frontiers in Virology, Journal Year: 2024, Volume and Issue: 4
Published: March 14, 2024
Introduction The severe acute respiratory syndrome coronavirus (SARS-CoV-2) spike (S) protein is essential in mediating membrane fusion of the virus with target cells. Several reports demonstrated that SARS-CoV-2 S fusogenicity reportedly closely associated intrinsic pathogenicity determined using hamster models. However, association between and other virological parameters remains elusive. Methods In this study, we investigated (e.g., S1/S2 cleavage efficiency, plaque size, pseudoviral infectivity, pseudovirus entry viral replication kinetics) eleven previous variants concern (VOCs) interest (VOIs) correlating fusogenicity. Results discussion was found to be strongly correlated efficiency size formed by clinical isolates. less kinetics. Taken together, our results suggest could potential indicators predict newly emerged variants.
Language: Английский
Citations
12
Heliyon, Journal Year: 2023, Volume and Issue: 9(11), P. e21369 - e21369
Published: Oct. 21, 2023
Breast cancer stands as the second most deadly form of among women worldwide. Early diagnosis and treatment can significantly mitigate mortality rates.
Language: Английский
Citations
20
Vaccines, Journal Year: 2022, Volume and Issue: 10(5), P. 702 - 702
Published: April 29, 2022
With the emergence and rapid spread of new pandemic variants, especially variants concern (VOCs), development next-generation vaccines with broad-spectrum neutralizing activities is great importance. In this study, SCTV01C, a clinical stage bivalent vaccine based on trimeric spike extracellular domain (S-ECD) SARS-CoV-2 Alpha (B.1.1.7) Beta (B.1.351) squalene-based oil-in-water adjuvant was evaluated in comparison to its two corresponding (Alpha Beta) monovalent mouse immunogenicity studies. The induced potent antibody responses against antigen-matched but drastic reductions titers antigen-mismatched were observed. comparison, SCTV01C relatively higher cross-neutralizing various including D614G variant, VOCs (B.1.1.7, B.1.351, P.1, B.1.617.2, B.1.1.529), interest (VOIs) (C.37, B.1.621), under monitoring (VUMs) (B.1.526, B.1.617.1, B.1.429, C.36.3) other (B.1.618, 20I/484Q). All three elicited Th1-biased T-cell immune responses. These results provide direct evidence that variant-based multivalent could play important roles addressing critical issue reduced protective efficacy existing emerging variants.
Language: Английский
Citations
24
IntechOpen eBooks, Journal Year: 2023, Volume and Issue: unknown
Published: Oct. 3, 2023
The proposed chapter aims to provide an overview of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant and its potential effects on public health. origins disease 2019 (COVID-19) pandemic SARS-CoV-2 virus evolution through time will be briefly covered at beginning with emphasis emergence new variants. next section present Omicron, outlining where it was first identified, key mutations that set apart from prior variants, how has spread worldwide. In following section, we discuss evidence regarding Omicron’s rapid in comparison other COVID-19 variants along any possible implications severity hospitalization rates. also explores could affect natural immunity vaccination efficiency information recent studies effectiveness vaccines against Omicron. Finally, health responses outline effective strategies can lessen effects.
Language: Английский
Citations
8
Human Vaccines & Immunotherapeutics, Journal Year: 2022, Volume and Issue: 18(1)
Published: Jan. 31, 2022
Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have recently been reported in many countries. These exacerbated the disease 2019 (COVID-19)-induced global health threats and hindered COVID-19 vaccine development therapeutic progress. This commentary discusses potential risk of newly classified Mu variant interest, seeming a highly vaccine-resistant variant, approaches that can be adopted to tackle this based on available evidence. The SARS-CoV-2 B.1.621 (Mu variant) lineage has shown approximately ten times higher resistance neutralizing sera obtained from survivors or BNT161b2-vaccinated people than parenteral B.1 lineage. urgent long-term strategic plans, including quick genomic surveillance for uncovering genetic characteristics variants, equitable mass vaccination, booster dose administration if required, strict implementation public measures non-pharmaceutical interventions, must undertaken concertedly restrict further infections, mutations, recombination virus its deadly strains.
Language: Английский
Citations
9
Biological Trace Element Research, Journal Year: 2024, Volume and Issue: unknown
Published: June 14, 2024
Language: Английский
Citations
1
Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(35), P. 13185 - 13190
Published: Aug. 23, 2023
Since the outbreak of COVID-19, SARS-CoV-2, infection has been spreading to date. The rate false-negative result on a polymerase chain reaction (PCR) test considered gold standard is roughly 20%. Therefore, its accuracy poses question as well needs improvement in test. This study reports fabrication substrate an anti-spike protein (AS)-immobilized porous material having selective adsorption toward spike protruding from surface SARS-CoV-2. We have employed organic polymer called spongy monolith (SPM). SPM through-pores about 10 μm and adequate for flowing liquid containing virus particles. It also involves epoxy group surface, enabling arbitrary proteins such antibodies immobilize. When receptor binding domain were immobilized, was observed. At same time, when mixed analytes proteins, lysozymes amylases, flowed into AS-SPM, Then, SARS-CoV-2 BSA-SPM or amounts AS-SPM much larger compared ones BSA-SPM. Furthermore, rotavirus not adsorbed at all. These results show that recognizes selectively may be possible applications purification concentration
Language: Английский
Citations
2
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown
Published: Oct. 3, 2023
Abstract The severe acute respiratory syndrome coronavirus (SARS-CoV-2) spike (S) protein is essential in mediating membrane fusion of the virus with target cells. Several reports demonstrated that SARS-CoV-2 S fusogenicity reportedly closely associated intrinsic pathogenicity determined using hamster models. However, association between and other virological parameters remains elusive. In this study, we investigated eleven previous variants concern (VOCs) interest (VOIs) correlating fusogenicity. was found to be strongly correlated S1/S2 cleavage efficiency plaque size formed by clinical isolates. less pseudoviral infectivity, pseudovirus entry efficiency, viral replication kinetics. Taken together, our results suggest could potential indicators predict newly emerged variants.
Language: Английский
Citations
2
Pathogens, Journal Year: 2023, Volume and Issue: 12(3), P. 438 - 438
Published: March 10, 2023
The present case study describes the dermatological manifestations of COVID-19 in a patient with genetic thrombophilia (MTHFR-C677T mutation) and identification SARS-CoV-2 variant interest (VOI). A female patient, 47 years old, unvaccinated, thrombophilia, was diagnosed COVID-19. She presented urticarial maculopapular eruptions from seventh day symptoms, which progressed to multiple lesions dark centers (D-dimer value > 1450 ng/mL). disappeared after 30 days, corroborating reduction D-dimer levels. Viral genome sequencing revealed infection by VOI Zeta (P.2). Antibody testing, performed days onset detected only IgG. virus neutralization test showed highest neutralizing titer for P.2 strain, validating genotypic identification. Lesions were suggested be due skin cells causing direct cytopathic effect or release pro-inflammatory cytokines triggering erythematous eruptions. In addition, vascular complications are also proposed MTHFR mutation increased values. This report is an alert about patients pre-existing diseases, especially unvaccinated patients, VOI.
Language: Английский
Citations
2