Inflammasome: structure, biological functions, and therapeutic targets

MedComm, Journal Year: 2023, Volume and Issue: 4(5)

Published: Oct. 1, 2023

Inflammasomes are a group of protein complex located in cytoplasm and assemble response to wide variety pathogen-associated molecule patterns, damage-associated cellular stress. Generally, the activation inflammasomes will lead maturation proinflammatory cytokines pyroptotic cell death, both associated with inflammatory cascade amplification. A sensor protein, an adaptor, procaspase interact through their functional domains compose one subunit inflammasome complex. Under physiological conditions, functions against pathogen infection endogenous dangers including mtROS, mtDNA, so on, while dysregulation its can unwanted results. In recent years, advances have been made clarify mechanisms activation, structural details them (negative/positive) multiple disease models animal human. The range stimuli makes function diverse Here, we review structure, biological functions, therapeutic targets inflammasomes, highlight NLRP3, NLRC4, AIM2 which most well studied. conclusion, this focuses on process, structure well-studied summarizing predicting approaches for treatment prevention as target. We aim provide fresh insight into new solutions challenges field.

Language: Английский

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Anti-inflammatory role of Artemisia argyi methanol extract by targeting the caspase-11 non-canonical inflammasome in macrophages

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 307, P. 116231 - 116231

Published: Feb. 6, 2023

Language: Английский

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Potential benefits of ginseng against COVID-19 by targeting inflammasomes

Journal of Ginseng Research, Journal Year: 2022, Volume and Issue: 46(6), P. 722 - 730

Published: April 5, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogenic virus that causes disease 2019 (COVID-19), with major symptoms including hyper-inflammation and cytokine storm, which consequently impairs system multiple organs, or even cause death. SARS-CoV-2 activates inflammasomes inflammasome-mediated inflammatory signaling pathways, are key determinants of hyperinflammation storm in COVID-19 patients. Additionally, inhibits inflammasome activation to evade host's antiviral immunity. Therefore, regulating initiation has received increasing attention as a preventive measure Ginseng its active constituents, ginsenosides saponins, improve immune exert anti-inflammatory effects by targeting stimulation. this review discussed potential therapeutic roles ginseng based on regulatory role

Language: Английский

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Korean Red Ginseng Saponins Play an Anti-Inflammatory Role by Targeting Caspase-11 Non-Canonical Inflammasome in Macrophages

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(2), P. 1077 - 1077

Published: Jan. 5, 2023

We previously reported that Korean red ginseng (KRG) exerts an anti-inflammatory role through inhibiting caspase-11 non-canonical inflammasome in macrophages; however, the components responsible for remained unclear. This study explored activity of KRG saponin fraction (KRGSF) inflammasome-activated macrophages. KRGSF inhibited pyroptosis, pro-inflammatory cytokine secretion, and inflammatory mediator production J774A.1 cells. A mechanism revealed KRGSF-induced action was mediated via suppressing proteolytic activation gasdermin D (GSDMD) Moreover, increased survival lethal septic mice. Taken together, these results reveal KRGSF-mediated with a novel mechanism, by

Language: Английский

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Roles of the Caspase-11 Non-Canonical Inflammasome in Rheumatic Diseases

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2091 - 2091

Published: Feb. 8, 2024

Inflammasomes are intracellular multiprotein complexes that activate inflammatory signaling pathways. comprise two major classes: canonical inflammasomes, which were discovered first and activated in response to a variety of pathogen-associated molecular patterns (PAMPs) danger-associated (DAMPs), non-canonical recently only lipopolysaccharide (LPS). Although larger number studies have successfully demonstrated particularly the NLRP3 inflammasome, play roles various rheumatic diseases, including rheumatoid arthritis (RA), infectious (IR), gouty (GA), osteoarthritis (OA), systemic lupus erythematosus (SLE), psoriatic (PA), ankylosing spondylitis (AS), Sjögren’s syndrome (SjS), regulatory such as mouse caspase-11 human caspase-4 these diseases still largely unknown. Interestingly, an increasing reported possible for inflammasomes pathogenesis models disease. This review comprehensively summarizes discusses recent emerging demonstrating focusing on progression types provides new insights into strategies developing potential therapeutics prevent treat well associated by targeting inflammasomes.

Language: Английский

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Regulatory Roles of Caspase-11 Non-Canonical Inflammasome in Inflammatory Liver Diseases

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(9), P. 4986 - 4986

Published: April 30, 2022

An inflammatory response consists of two consecutive steps: priming and triggering, to prepare activate responses, respectively. The cardinal feature the triggering step is activation intracellular protein complexes called inflammasomes, which provide a platform for signaling pathways. Despite many studies demonstrating regulatory roles canonical inflammasomes in liver diseases, newly discovered non-canonical diseases are still largely unknown. Recent have reported caspase-11 inflammasome providing strong evidence that may play key pathogenesis diseases. This review comprehensively discusses emerging focusing on non-alcoholic fatty disease (NAFLD), steatohepatitis (NASH), injuries its underlying mechanisms. highlights current knowledge new insights into development potential therapeutics prevent treat by targeting inflammasome.

Language: Английский

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Role of Pyroptosis in inflammatory bowel disease

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 155, P. 114619 - 114619

Published: April 10, 2025

Language: Английский

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Regulatory Roles of Flavonoids in Caspase-11 Non-Canonical Inflammasome-Mediated Inflammatory Responses and Diseases

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 10402 - 10402

Published: June 20, 2023

Inflammasomes are multiprotein complexes that activate inflammatory responses by inducing pyroptosis and secretion of pro-inflammatory cytokines. Along with many previous studies on diseases induced canonical inflammasomes, an increasing number have demonstrated non-canonical such as mouse caspase-11 human caspase-4 emerging key players in various diseases. Flavonoids natural bioactive compounds found plants, fruits, vegetables, teas pharmacological properties a wide range Many successfully flavonoids play anti-inflammatory role ameliorate inhibiting inflammasomes. Others the roles diseases, new mechanism which inhibit This review discusses recent investigated inflammasomes further provides insight into developing flavonoid-based therapeutics potential nutraceuticals against

Language: Английский

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Regulatory roles of noncanonical inflammasomes in kidney diseases

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 157, P. 114787 - 114787

Published: May 3, 2025

Language: Английский

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MicroRNA-mediated epigenetic regulation of inflammasomes in inflammatory responses and immunopathologies

Seminars in Cell and Developmental Biology, Journal Year: 2022, Volume and Issue: 154, P. 227 - 238

Published: Nov. 25, 2022

Language: Английский

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