Seminars in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 154, P. 165 - 166
Published: Sept. 7, 2023
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2091 - 2091
Published: Feb. 8, 2024
Inflammasomes are intracellular multiprotein complexes that activate inflammatory signaling pathways. comprise two major classes: canonical inflammasomes, which were discovered first and activated in response to a variety of pathogen-associated molecular patterns (PAMPs) danger-associated (DAMPs), non-canonical recently only lipopolysaccharide (LPS). Although larger number studies have successfully demonstrated particularly the NLRP3 inflammasome, play roles various rheumatic diseases, including rheumatoid arthritis (RA), infectious (IR), gouty (GA), osteoarthritis (OA), systemic lupus erythematosus (SLE), psoriatic (PA), ankylosing spondylitis (AS), Sjögren’s syndrome (SjS), regulatory such as mouse caspase-11 human caspase-4 these diseases still largely unknown. Interestingly, an increasing reported possible for inflammasomes pathogenesis models disease. This review comprehensively summarizes discusses recent emerging demonstrating focusing on progression types provides new insights into strategies developing potential therapeutics prevent treat well associated by targeting inflammasomes.
Language: Английский
Citations
5
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: July 20, 2023
Inflammasomes are multiprotein signaling platforms in the cytosol that senses exogenous and endogenous danger signals respond with maturation secretion of IL-1β IL-18 pyroptosis to induce inflammation protect host. The inflammasome best studied is Nucleotide-binding oligomerization domain, leucine-rich repeat-containing family pyrin domain containing 3 (NLRP3) inflammasome. It activated a two-step process: priming activation, leading sensor NLRP3 recruitment both adaptor ASC executioner pro-caspase 1, which by cleavage. Moreover, activation regulated posttranslational modifications, including ubiquitination/deubiquitination, phosphorylation/dephosphorylation, acetylation/deacetylation, SUMOylation nitrosylation, interaction NLPR3 protein binding partners. connection between it metabolism receiving increasing attention this field. In review, we present structure, functions, regulation NLRP3, special emphasis on mitochondrial dysfunction-mtROS production metabolic signals, i.e., metabolites as well enzymes. By understanding specific inhibitors can be rationally designed for treatment prevention various immune- or metabolic-based diseases. Lastly, review current their mechanism action.
Language: Английский
Citations
13
Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14
Published: Aug. 16, 2023
Extracellular vesicles (EVs), including exosomes, play a crucial role in intercellular communication and have emerged as important mediators the development progression of gastric cancer. This review discusses current understanding EVs, particularly exosomal lncRNA microRNA, cancer their potential diagnostic therapeutic targets. Exosomes are small membrane-bound particles secreted by both cells stromal within tumor microenvironment. They contain various ncRNA biomolecules, which can be transferred to recipient promote growth metastasis. In this review, we highlighted importance microRNA Exosomal lncRNAs been shown regulate gene expression interacting with transcription factors or chromatin-modifying enzymes, binding target mRNAs. We also discuss use microRNAs biomarkers for isolated from bodily fluids, blood, urine, saliva. specific molecules that reflect molecular characteristics tumor, making them promising candidates non-invasive tests. Finally, targeting strategy were reviewed wee. Inhibition exosomes has suppress metastasis preclinical models. conclusion, article provides an overview suggest further research into these could lead new tools strategies deadly disease.
Language: Английский
Citations
12
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 129, P. 111615 - 111615
Published: Feb. 7, 2024
Language: Английский
Citations
4
Theriogenology, Journal Year: 2025, Volume and Issue: 237, P. 76 - 84
Published: Feb. 10, 2025
Language: Английский
Citations
0
ACS Pharmacology & Translational Science, Journal Year: 2025, Volume and Issue: unknown
Published: April 30, 2025
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 10402 - 10402
Published: June 20, 2023
Inflammasomes are multiprotein complexes that activate inflammatory responses by inducing pyroptosis and secretion of pro-inflammatory cytokines. Along with many previous studies on diseases induced canonical inflammasomes, an increasing number have demonstrated non-canonical such as mouse caspase-11 human caspase-4 emerging key players in various diseases. Flavonoids natural bioactive compounds found plants, fruits, vegetables, teas pharmacological properties a wide range Many successfully flavonoids play anti-inflammatory role ameliorate inhibiting inflammasomes. Others the roles diseases, new mechanism which inhibit This review discusses recent investigated inflammasomes further provides insight into developing flavonoid-based therapeutics potential nutraceuticals against
Language: Английский
Citations
10
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: May 12, 2024
Abstract Background Myeloid-derived suppressor cells (MDSCs) promote tumor growth, metastasis, and lead to immunotherapy resistance. Studies revealed that miRNAs are also expressed in MDSCs the immunosuppressive function of MDSCs. Currently, few studies have been reported on inducible cellular microvesicle delivery nucleic acid drugs targeting miRNA for treatment malignant tumors. Results conclusion In this study, we designed an artificial DNA named G-quadruplex-enhanced circular single-stranded DNA-9 (G4-CSSD9), specifically adsorbs miR-9 sequence. Its advanced folding structure, rich tandem repeat guanine (G-quadruplex), provides good stability. Mesenchymal stem (MSCs) were prepared into nanostructured vesicles by membrane extrusion. The MSC microvesicles-encapsulated G4-CSSD9 (MVs@G4-CSSD9) was delivered MDSCs, which affected downstream transcription translation process, reduced so as achieve purpose treating melanoma. particular, it idea treatment. Graphical
Language: Английский
Citations
3
Biology, Journal Year: 2025, Volume and Issue: 14(1), P. 71 - 71
Published: Jan. 14, 2025
The prevalence of osteoarthritis (OA) notably surges with age and weight gain. most common clinical therapeutic drugs are painkillers, yet they cannot impede the deteriorating course OA. Thus, understanding OA's pathogenesis devising effective therapies is crucial. It generally recognized that inflammation, pyroptosis, OA progression tightly linked. activation NLRP3 inflammasome can lead to discharge pro-inflammatory cytokines Interleukin-1β IL-18, intensifying subsequent inflammatory reactions promoting development. Conversely, imbalance caused by deacetylase-regulated underlies chronic mild inflammation related degenerative diseases. Therefore, this article expounds on mechanism role histone deacetylases (HDACs) in inflammasome-triggered OA, illustrates application HDAC inhibitors striving provide more insights into novel treatment approaches.
Language: Английский
Citations
0
International Immunopharmacology, Journal Year: 2025, Volume and Issue: 157, P. 114787 - 114787
Published: May 3, 2025
Language: Английский
Citations
0