Sodium butyrate alleviates experimental autoimmune prostatitis by inhibiting oxidative stress and NLRP3 inflammasome activation via the Nrf2/HO‐1 pathway DOI
Xiaoliang Hua, Jiong Zhang, Juan Chen

et al.

The Prostate, Journal Year: 2024, Volume and Issue: 84(7), P. 666 - 681

Published: March 5, 2024

Abstract Background Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS) leads to severe discomfort in males loss of sperm quality. Current therapeutic options have failed achieve satisfactory results. Sodium butyrate (NaB) plays a beneficial role reducing inflammation, increasing antioxidant capacities, improving organ dysfunction; additionally NaB has good safety prospects great potential for clinical application. The purpose the current research was study effect on CP/CPPS underlying mechanisms using mouse model experimental autoimmune (EAP) mice. Methods EAP successfully established by subcutaneously injecting mixture prostate antigen complete Freund's adjuvant. Then, mice received daily intraperitoneal injections (100, 200, or 400 mg/kg/day) 16 days, from Days 26 42. We then explored anti‐inflammatory studying effects Nrf2 inhibitor ML385 HO‐1 zinc protoporphyrin inflammation this model. On Day 42, hematoxylin‐eosin staining dihydroethidium were used evaluate histological changes oxidative stress levels tissues. assessed applying Von Frey filaments lower abdomen. inflammation‐related cytokines, such as interleukin (IL)−1β, IL‐6, tumor necrosis factor detected enzyme‐linked immunosorbent assay. regulation Nrf2/HO‐1 signaling pathway expression NLRP3 inflammasome‐related protein western blot analysis Results Compared with group, development, manifestations, cytokine showed that reduced severity EAP. treatment could inhibit inflammasome activation. Mechanism studies intervention alleviate through signal pathway. inhibitors can ‐mediated stress. inhibitory activation also be blocked Conclusions alleviates prostatic associated inhibiting via an effective agent

Language: Английский

Natural product-derived ferroptosis mediators DOI
Yili Chen,

Lin-An Xiong,

Lie‐Feng Ma

et al.

Phytochemistry, Journal Year: 2024, Volume and Issue: 219, P. 114002 - 114002

Published: Jan. 27, 2024

Language: Английский

Citations

13
Hypoxia and ferroptosis DOI Creative Commons
Xiaoqian Liu,

Meng-Zhen Shi,

Yuting Bai

et al.

Cellular Signalling, Journal Year: 2024, Volume and Issue: 122, P. 111328 - 111328

Published: Aug. 1, 2024

Ferroptosis is a novel, iron-dependent cell death characterized by the excessive accumulation of ferroptosis lipid peroxides ultimately leading to oxidative damage membrane. Iron, lipid, amino acid metabolism, and other signaling pathways all control ferroptosis. Numerous bodily tissues experience hypoxia under normal pathological circumstances. Tissue cells can adjust these changes activating hypoxia-inducible factor (HIF) pathway mechanisms in response hypoxic environment. In recent years, there has been increasing evidence that are closely linked, regulate specific conditions through different pathways. this paper, we review possible positive negative regulatory factors, as well ferroptosis-associated ischemic diseases, with intention delivering novel therapeutic avenues for defense management illnesses linked

Language: Английский

Citations

11
Research hotspots and future trends in sepsis-associated acute kidney injury: a bibliometric and visualization analysis DOI Creative Commons

Xingyue Chen,

Lijia Zhi, Jun Chen

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 7, 2025

Sepsis-associated acute kidney injury (SA-AKI) commonly occurs in critically ill patients and is closely associated with adverse outcomes. A comprehensive analysis of the current research landscape SA-AKI can help uncover trends key issues this field. This study aims to provide a scientific basis for directions critical through bibliometric analysis. We searched all articles on indexed SCI-Expanded WoSCC up May 7, 2024, conducted visual analyses using software CiteSpace VOSviewer. Over past 20 years, there has been steady increase literature related renal repair following AKI. China United States contribute over 60% publications, driving The University Pittsburgh most active academic institution, producing highest number publications. J. A. Kellum both prolific cited author area. "Shock" "American Journal Physiology-Renal Physiology" are popular journals, publishing articles. Recent high-frequency keywords field include "septic AKI," "mitochondrial dysfunction," "inflammasome," "ferroptosis," "macrophage." terms "macrophage" represent hotspots potential targets first summarize advancements recent years. These findings identify frontiers hot topics, providing valuable insights scholars studying SA-AKI.

Language: Английский

Citations

1
Melatonin and ferroptosis: Mechanisms and therapeutic implications DOI
Dongni Zhang,

Xiaotong Jia,

Duomao Lin

et al.

Biochemical Pharmacology, Journal Year: 2023, Volume and Issue: 218, P. 115909 - 115909

Published: Nov. 4, 2023

Language: Английский

Citations

22
Brusatol hinders the progression of bladder cancer by Chac1/Nrf2/SLC7A11 pathway DOI Creative Commons

Xi Yu,

Ziqi He, Zhong Wang

et al.

Experimental Cell Research, Journal Year: 2024, Volume and Issue: 438(2), P. 114053 - 114053

Published: April 24, 2024

Bladder cancer is a common tumor that impacts the urinary system and marked by significant fatality rate an unfavorable prognosis. Promising antineoplastic properties are exhibited brusatol, which obtained from dried ripe fruit of Brucea javanica. The present study aimed to evaluate influence brusatol on progression bladder uncover molecular mechanism involved. We used Cell Counting Kit-8, colony formation EdU assays detect cell numbers, viability proliferation. transwell migration assay ability. inhibition proliferation was studied flow cytometry western blotting. It revealed could reduce T24 5637 cells. able attenuate found treatment with increased levels reactive oxygen species, malondialdehyde Fe2+, thereby further promoting ferroptosis in In addition, RSL3 (an agonistor ferroptosis) ferrostatin-1 (a selective inhibitor enhanced or reversed brusatol-induced inhibition. vivo, significantly suppressed growth nude mice. Mechanistically, induced upregulating expression ChaC glutathione-specific gamma-glutamylcyclotransferase (Chac1) decreasing SLC7A11 Nrf2 To summarize, findings this research demonstrated hindered triggered via Chac1/Nrf2/SLC7A11 pathway.

Language: Английский

Citations

7
Advance in Iron Metabolism, Oxidative Stress and Cellular Dysfunction in Experimental and Human Kidney Diseases DOI Creative Commons

Tiancheng Xie,

Li Yao, Xiaogang Li

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(6), P. 659 - 659

Published: May 27, 2024

Kidney diseases pose a significant global health issue, frequently resulting in the gradual decline of renal function and eventually leading to end-stage failure. Abnormal iron metabolism oxidative stress-mediated cellular dysfunction facilitates advancement kidney diseases. Iron homeostasis is strictly regulated body, disturbance this regulatory system results abnormal accumulation or deficiency, both which are associated with pathogenesis overload promotes production reactive oxygen species (ROS) through Fenton reaction, damage molecules impaired function. Increased stress can also influence upregulation proteins altering expression activity key transport storage proteins. This creates harmful cycle perpetuate each other, ultimately contributing The crosstalk involves multiple signaling pathways, such as hypoxia-inducible factor (HIF) nuclear erythroid 2-related 2 (Nrf2) pathways. review delves into functions mechanisms stress, along intricate relationship between these two factors context Understanding underlying should help identify potential therapeutic targets develop novel effective strategies combat burden

Language: Английский

Citations

6
Melatonin alleviates LPS-induced depression-like behavior in mice by inhibiting ferroptosis by regulating RNA methylation-mediated SIRT6/Nrf2/HO-1 pathway DOI
Wenjie Su, Jia Deng, Li-Na Yang

et al.

European Journal of Nutrition, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

Language: Английский

Citations

6
LPS-aggravated Ferroptosis via Disrupting Circadian Rhythm by Bmal1/AKT/p53 in Sepsis-Induced Myocardial Injury DOI
Hao Lin, Fang Ji,

Kong-qin Lin

et al.

Inflammation, Journal Year: 2023, Volume and Issue: 46(4), P. 1133 - 1143

Published: April 13, 2023

Language: Английский

Citations

16
Ischemia/reperfusion-activated ferroptosis in the early stage triggers excessive inflammation to aggregate lung injury in rats DOI Creative Commons
Xiujie Liu,

Binhui Pan,

Xiaoting Wang

et al.

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: June 23, 2023

Lung ischemia/reperfusion injury (LIRI) is a clinical syndrome of acute lung that occurs after transplantation or remote organ ischemia. Ferroptosis and inflammation are involved in the pathogenesis LIRI according to results several studies on animal models. However, interactive mechanisms between ferroptosis contributing remain unclear.HE staining indicators oxidative stress were used evaluated injury. The reactive oxygen species (ROS) level was examined by DHE staining. quantitative Real-time PCR (qRT-PCR) western blot analysis employed detect ferroptosis, deferoxamine (DFO) assess importance its effect inflammation.In present study, link with at reperfusion 30-, 60- 180-minute time points, respectively. As 30-minute point shown, pro-ferroptotic indicators, especially cyclooxygenase (COX)-2 acyl-CoA synthetase long-chain family member 4 (ACSL4), upregulated while anti-ferroptotic factors glutathione peroxidase (GPX4), cystine-glumate antiporter (XCT) ferritin heavy chain (FTH1) downregulated. Meanwhile, increased interleukin (IL)-6, tumor necrosis factor alpha (TNF-α) IL-1β observed beginning 60-minute but mostly activated point. Furthermore, block which can alleviate Expectedly, survival rate rats mitigated containing improvement type II alveolar cells ultrastructure ROS production. In addition, point, be dramatically inhibited DFO administration as verified IL-6, TNF-α detection.These findings suggest ischemia/reperfusion-activated plays an important role trigger for further deteriorate damages. Inhibiting may have therapeutic potential practice.

Language: Английский

Citations

15
Farnesoid X receptor protects against lipopolysaccharide-induced endometritis by inhibiting ferroptosis and inflammatory response DOI
Lu Cao, Rui Qin,

Junbao Liu

et al.

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 118, P. 110080 - 110080

Published: March 29, 2023

Language: Английский

Citations

14