The mechanism of ferroptosis and its related diseases

Molecular Biomedicine, Journal Year: 2023, Volume and Issue: 4(1)

Published: Oct. 16, 2023

Abstract Ferroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation lipid peroxides, provides novel avenue for delving into intersection metabolism, oxidative stress, and disease pathology. We have witnessed mounting fascination with ferroptosis, attributed to its pivotal roles across diverse physiological pathological conditions including developmental processes, metabolic dynamics, oncogenic pathways, neurodegenerative cascades, traumatic tissue injuries. By unraveling intricate underpinnings molecular machinery, contributors, signaling conduits, regulatory networks governing researchers aim bridge gap between intricacies this unique mode multifaceted implications health disease. In light rapidly advancing landscape ferroptosis research, we present comprehensive review aiming at extensive in origins progress human diseases. This concludes careful analysis potential treatment approaches carefully designed either inhibit or promote ferroptosis. Additionally, succinctly summarized therapeutic targets compounds that hold promise targeting within various facet underscores burgeoning possibilities manipulating as strategy. summary, enriched insights both investigators practitioners, while fostering an elevated comprehension latent translational utilities. revealing basic processes investigating possibilities, crucial resource scientists medical aiding deep understanding effects situations.

Language: Английский

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Farnesoid X Receptor Plays a Key Role in Ochratoxin A-Induced Nephrotoxicity by Targeting Ferroptosis In Vivo and In Vitro

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(39), P. 14365 - 14378

Published: Sept. 26, 2023

The mycotoxin ochratoxin A (OTA) causes nephrotoxicity, hepatotoxicity, and immunotoxicity in animals humans. farnesoid X receptor (FXR) is a member of the NR family highly expressed kidney, which has an antilipid production function. Ferroptosis iron-dependent form regulated cell death involved several pathophysiological kidney injury. present study aims to evaluate role FXR ferroptosis OTA-induced nephrotoxicity mice HK-2 cells. Results showed that OTA induced as demonstrated by inducing histopathological lesions neutrophil infiltration increasing serum BUN, CRE, UA levels, Ntn-1, Kim-1, pro-inflammatory cytokine expression, decreasing IL-10 expression viability treatment also deficiency, ROS release, MDA level increase, GSH content decrease, 4-HNE labile iron pool lipid peroxidation levels well Acsl4, TFR1, HO-1 mRNA protein GPX4 FTH expressions, mitochondrial activator (GW4064) rescued accumulation peroxides, intracellular ROS, Fe2+, inhibited ferroptosis, alleviated nephrotoxicity. inhibitor (Fer-1) prevented attenuated Collectively, this elucidates played critical via regulation provides novel strategy against

Language: Английский

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Nuciferine protects against lipopolysaccharide-induced endometritis via inhibiting ferroptosis and modulating AMPKα/mTOR/HIF-1α signaling axis

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 124, P. 110914 - 110914

Published: Sept. 19, 2023

Language: Английский

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Spotlight on iron overload and ferroptosis: Research progress in female infertility

Life Sciences, Journal Year: 2023, Volume and Issue: 340, P. 122370 - 122370

Published: Dec. 22, 2023

Language: Английский

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Regulation of gut microbiota on immune cell ferroptosis: A novel insight for immunotherapy against tumor

Cancer Letters, Journal Year: 2024, Volume and Issue: 598, P. 217115 - 217115

Published: July 17, 2024

Language: Английский

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Astilbin from Smilax china L. remarkably inhibits LPS-induced endometritis in rats via blocking positive feedback between TLR4 and IL-6R signalling pathways in a PPAR-γ-dependent manner

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119861 - 119861

Published: April 1, 2025

Language: Английский

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The mechanism of action of safflower total flavonoids in the treatment of endometritis caused by incomplete abortion based on network pharmacology and 16S rDNA sequencing

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 315, P. 116639 - 116639

Published: May 16, 2023

Safflower is a traditional Chinese medicine used for treating gynaecological diseases. However, its material basis and mechanism of action in the treatment endometritis induced by incomplete abortion are still unclear.This study aimed to reveal safflower through comprehensive methods, including network pharmacology 16S rDNA sequencing.Network molecular docking methods were screen main active components potential mechanisms rats. A rat model endometrial inflammation was established. The rats treated with total flavonoids (STF) based on forecasting results, serum levels inflammatory cytokines analysed, immunohistochemistry, Western blots, sequencing performed investigate effects ingredient mechanism.The prediction results showed 20 260 targets safflower, 1007 related caused abortion, 114 drug-disease intersecting targets, TNF, IL6, TP53, AKT1, JUN, VEGFA, CASP3 other core PI3K/AKT, MAPK signalling pathways may be closely leading endometritis. animal experiment that STF could significantly repair uterine damage reduce amount bleeding. Compared group, down-regulated pro-inflammatory factors (IL-6, IL-1β, NO, TNF-α) expression JNK, ASK1, Bax, caspase3, caspase11 proteins. At same time, anti-inflammatory (TGF-β PGE2) protein ERα, PI3K, AKT, Bcl2 up-regulated. Significant differences intestinal flora seen between normal group closer after administration STF.The characteristics multi-targeted involved multiple pathways. activation ERα/PI3K/AKT pathway regulating composition ratio gut microbiota.

Language: Английский

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Metabolic dysfunction-associated steatotic liver disease: ferroptosis related mechanisms and potential drugs

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 9, 2023

Metabolic dysfunction-associated steatotic liver disease (MASLD) is considered a "multisystem" that simultaneously suffers from metabolic diseases and hepatic steatosis. Some may develop into fibrosis, cirrhosis, even hepatocellular carcinoma. Given the close connection between fatty liver, it urgent to identify drugs can control as whole delay progression. Ferroptosis, characterized by iron overload lipid peroxidation resulting abnormal metabolism, programmed cell death mechanism. It an important pathogenic mechanism in or become key direction for improving MASLD. In this article, we have summarized physiological pathological mechanisms of metabolism ferroptosis, well connections established through ferroptosis. We also MASLD therapeutic potential active substances targeting order provide readers with new insights. At same time, future clinical trials involving subjects (especially intervention drugs), detection serum levels ferroptosis markers patients should be increased further explore efficacy on

Language: Английский

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Ursodeoxycholic acid alleviates fat embolism syndrome-induced acute lung injury by inhibiting the p38 MAPK/NF-κB signalling pathway through FXR

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 230, P. 116574 - 116574

Published: Oct. 11, 2024

Language: Английский

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Caffeic acid inhibits Staphylococcus aureus‐induced endometritis through regulating AMPKα/mTOR/HIF‐1α signalling pathway

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(20)

Published: Oct. 1, 2024

Abstract Endometritis is mostly caused by childbirth or postpartum uterine infection. It one of the important reasons leading to female infertility. Caffeic acid (CA) and its derivatives are widely found in some foods traditional Chinese medicine, have biological activities such as antioxidant, free radical scavenging, anti‐inflammatory, anti‐infection. In this study, we aimed explore effect CA on Staphylococcus aureus ‐induced endometritis. The contents TNF‐α IL‐1β were detected ELISA S. endometritis model. Western blot assay was used detect expression AMPKα/mTOR/HIF‐1α pathway related proteins GPX4 expression. addition, concentrations MDA, GSH, iron tested kits. Compared with model group, treatment significantly alleviated injury, MPO activity, inflammatory factors IL‐1β, NF‐κB activation. Meanwhile, inhibited ferroptosis, confirmed decreased MDA concentration up‐regulated GSH level. Furthermore, attenuated HIF‐1α phosphorylated mTOR increased AMPK conclusion, inhibits inflammation ferroptosis regulating signalling alleviate mice.

Language: Английский

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