Exploring New Mechanism of Depression from the Effects of Virus on Nerve Cells

Cells, Journal Year: 2023, Volume and Issue: 12(13), P. 1767 - 1767

Published: July 3, 2023

Depression is a common neuropsychiatric disorder with long-term recurrent depressed mood, pain and despair, pessimism anxiety, even suicidal tendencies as the main symptoms. usually induces or aggravates development of other related diseases, such sleep disorders endocrine disorders. In today's society, incidence depression increasing worldwide, its pathogenesis complex generally believed to be genetic, psychological, environmental, biological factors. Current studies have shown key role glial cells in depression, it noteworthy that some recent evidence suggests may closely viral infections, SARS-CoV-2, BoDV-1, ZIKV, HIV, HHV6, which infect organism cause degree cells, astrocytes, oligodendrocytes, microglia. This can affect transmission proteins, neurotransmitters, cytokines, turn leads neuroinflammation depression. Based on close relationship between viruses this paper provides an in-depth analysis new mechanism virus-induced expected provide perspective idea for diagnosis future.

Language: Английский

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Epigenetic Modulation of Inflammatory Pathways in Myometrial Stem Cells and Risk of Uterine Fibroids

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(14), P. 11641 - 11641

Published: July 19, 2023

The period during which tissue and organ development occurs is particularly vulnerable to the influence of environmental exposures. However, specific mechanisms through biological pathways are disrupted in response developmental insults, consequently elevating risk hormone-dependent diseases, such as uterine fibroids (UFs), remain poorly understood. Here, we show that exposure endocrine-disrupting chemical (EDC), diethylstilbestrol (DES), activates inflammatory myometrial stem cells (MMSCs), origin UFs. Significantly, secretome reprogrammed MMSCs enhances expression critical inflammation-related genes differentiated paracrine mechanism, amplifies pro-inflammatory immune suppression signaling myometrium. responsive (IRGs) driven by activated mixed-lineage leukemia protein-1 (MLL1) MMSCs. deactivation MLL reverses reprogramming IRG expression. In addition, inhibition histone deacetylases (HDACs) also reversed induced EDC exposure. This work identifies epigenetic MLL1/HDAC-mediated MMSC reprogramming, epigenetically targets imparts an pattern, may result a "hyper-inflammatory phenotype" increased UFs later life.

Language: Английский

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Xiaoyaosan against depression through suppressing LPS mediated TLR4/NLRP3 signaling pathway in “microbiota-gut-brain” axis

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 335, P. 118683 - 118683

Published: Aug. 8, 2024

Language: Английский

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Targeting the NLRP3 inflammasome as a novel therapeutic target for osteoarthritis

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Language: Английский

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Role of NLRP3 Inflammasome in Chronic Pain and Alzheimer's Disease—A Review

Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(2)

Published: Jan. 23, 2025

ABSTRACT The coexistence of Alzheimer's disease (AD) and chronic pain (CP) in the elderly population has been extensively documented, a growing body evidence supports potential interconnections between these two conditions. This comprehensive review explores mechanisms by which CP may contribute to development progression AD, with particular focus on neuroinflammatory pathways role microglia, as well activation NLR family pyrin domain containing 3 (NLRP3) inflammasome. proposes that prolonged processing critical brain regions can dysregulate activity NLRP3 inflammasome within leading overproduction pro‐inflammatory cytokines excessive oxidative stress regions. aberrant microglial response also results localized neuroinflammation areas crucial for cognitive function. Additionally, persistent physiological psychological stressor be associated hypothalamic‐pituitary‐adrenal (HPA) axis dysfunction, systemic inflammation, disruption blood–brain barrier (BBB), neuroinflammation. These pathophysiological changes cause morphological functional impairments responsible cognition, memory, neurotransmitter production, potentially contributing CP‐associated AD. Resultant further promote amyloid‐beta (Aβ) plaque deposition, hallmark AD pathology. Potential therapeutic interventions targeting pathways, particularly through regulation activation, hold promise improving outcomes individuals comorbid However, research is required fully elucidate complex interplay conditions develop effective treatment strategies.

Language: Английский

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AI Perspectives on the Present and Future of Antidepressant Pharmaceutical Treatment Based on Anti-inflammatory Strategies: A Scoping Review of Randomised Controlled Clinical Trials

Published: Jan. 26, 2025

Recently, a novel concept of 'anti-inflammatory-based pharmacotherapy' has been developed. The aim this scoping review was precisely to explore in depth the current status inflammation randomised controlled clinical trial studies depression. PubMed systematically searched from inception December 11 2024. Studies that researches on treatment depression based anti-inflammatory strategies were included. Study characteristics and outcomes extracted organized thematically. reports trials included, which accumulated 119 depressed patients. All found there is connection between effects drugs treating large decrease levels inflammatory markers blood patients compared before treatment. Three markers, CRP, IL-6 TNF-alpha, most frequently mentioned. strategy drug administration did not differ fundamentally previous traditional antidepressant combined with psychotherapy. At present, use for pharmacological limited research value poor feasibility. potential feasibility future lies application an integrated AI platform assist strategies. Registration DOI: https://doi.org/10.17605/OSF.IO/A64GC

Language: Английский

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Downregulation of the HCN1 Channel Alleviates Anxiety‐ and Depression‐Like Behaviors in Mice With Cerebral Ischemia–Reperfusion Injury by Suppressing the NLRP3 Inflammasome

Journal of the American Heart Association, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Background Post‐stroke depression (PSD) is a prevalent neuropsychiatric complication of stroke. However, the mechanisms underlying PSD are still unclear. Here, we aimed to investigate role HCN1 (hyperpolarization‐activated cyclic nucleotide‐gated cation channel 1) in pathogenesis and its mechanisms. Methods The mice model was established by middle cerebral artery occlusion vivo. Four weeks after occlusion, anxiety‐ depression‐like behaviors were evaluated various behavioral tests. HCN channels downregulated pharmacological inhibitor or neuron‐specific adeno‐associated virus. oxygen–glucose deprivation/reoxygenation SY5Y cells used study vitro. Results Mice exhibited behavior 4 along with significant increase protein expression ischemic hippocampus. Furthermore, I h current on neurons hippocampus notably enhanced, whereas neuronal excitability decreased mice. Treatment selective ZD7288 protected against injury suppressing K + efflux. Additionally, observed expressions NLRP3 (nucleotide‐binding domain‐like receptor 3) inflammasome pathway‐related molecules Knockdown via virus injection into resulted inflammasome‐related improvement Conclusions Downregulation has beneficial effect pathway, thus offering promise as strategy for preventing treating PSD.

Language: Английский

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Ginsenoside Re Inhibits NLRP3 Inflammasome Activation in Depressive Mice by Promoting PINK1-Mediated Mitophagy

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Ginsenoside Re (Re) was proved effective in improving depressive-like behaviors. However, the potential antidepressant mechanism of remains unrevealed. In this study, we investigated whether PINK1-mediated mitophagy and NLRP3 inflammasomes were linked to chronic unpredictable mild stress (CUMS) mice lipopolysaccharide (LPS)-stimulated astrocytes. RNA sequencing bioinformatics analyses performed discover targets pathways associated with Re. PTEN-induced putative kinase 1 (PINK1) knockdown conducted clarify role The outcomes showed that ameliorated behaviors, activated mitophagy, inhibited inflammasome activation. PINK1 attenuated effect promotion decline activation caused by reversed knockdown. conclusion, promoting exert its effect.

Language: Английский

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Paeoniflorin Alleviates Lipopolysaccharide-Induced Neuroinflammation and Depression Through the Keap1/Nrf2/HO-1 Signaling Pathway

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 585 - 585

Published: May 13, 2025

Depression is associated with bidirectional interactions between inflammatory responses and behavioral dysfunction. Paeoniflorin (PF), a monoterpene glycoside derived from Paeonia lactiflora, exhibits potent anti-inflammatory properties. This study investigates the therapeutic effects of PF on lipopolysaccharide (LPS)-induced depression-like behaviors in mice neuroinflammation BV2 microglial cells. Mice were co-administered (20, 40, or 80 mg/kg/day) LPS (2 mg/kg) for 7 days. Behavioral tests; Nissl staining; Golgi, Iba1, DLG4, cytokine assays conducted. Additionally, hippocampal NF-κB, Nrf2, BDNF signaling pathways analyzed using Western blots. In cells, oxidative stress Nrf2/HO-1 pathway assessed CCK-8, flow cytometry, blotting after 24 h treatment. significantly alleviated LPS-induced behaviors, increased neuron dendritic spine density, upregulated synaptic proteins (PSD95, SNAP25, BDNF). Mechanistically, suppressed NLRP3 inflammasome activation via Akt/GSK3β pathway, reduced pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), enhanced antioxidant axis. restored mitochondrial membrane potential, inhibited apoptosis, decreased levels IL-6) by inhibiting TLR4/NF-κB signaling. conclusion, improved attenuated highlighting its potential as agent inflammation-associated depression.

Language: Английский

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Sporoderm-removed Ganoderma lucidum spores ameliorated early depression-like behavior in a rat model of sporadic Alzheimer’s disease

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: April 24, 2024

: (G. lucidum, Lingzhi) is a medicinal and edible homologous traditional Chinese medicine that used to treat various diseases, including Alzheimer's disease mood disorders. We previously reported the sporoderm-removed

Language: Английский

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