Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 3, 2024
ABSTRACT
Osteoporosis
(OP)
is
a
globally
prevalent
bone
disease
characterized
by
reduced
mass
and
heightened
fracture
risk,
posing
significant
health
economic
challenge
to
aging
societies
worldwide.
Osteoimmunology—an
emerging
field
of
study—investigates
the
intricate
relationship
between
skeletal
immune
systems,
providing
insights
into
system's
impact
on
progression.
Recent
research
has
demonstrated
essential
roles
played
various
cells
(T
cells,
B
macrophages,
dendritic
mast
granulocytes,
innate
lymphoid
cells)
in
regulating
metabolism,
homeostasis,
formation,
remodeling
through
interactions
with
osteoclasts
(OC)
osteoblasts
(OB).
These
findings
underscore
that
osteoimmunology
provides
an
theoretical
framework
for
understanding
pathogenesis
disorders,
including
OP.
Traditional
Chinese
medicine
(TCM)
its
active
ingredients
have
clinical
value
OP
treatment.
Unfortunately,
despite
their
striking
multieffect
pathways
pharmacological
field,
current
not
yet
summarized
them
comprehensive
detailed
manner
respect
interventional
diseases,
especially
Consequently,
this
review
addresses
recent
studies
mechanisms
which
communication
molecules
contribute
development.
Additionally,
it
explores
potential
therapeutic
benefits
TCM
components
treating
from
perspective
osteoimmunology.
The
objective
provide
enhances
immune‐related
diseases
facilitate
development
novel
strategies.
Immunity Inflammation and Disease,
Journal Year:
2024,
Volume and Issue:
12(6)
Published: June 1, 2024
Ischemia-reperfusion
(I/R)
injury,
resulting
from
blood
flow
interruption
and
its
subsequent
restoration,
is
a
prevalent
complication
in
liver
surgery.
The
liver,
as
crucial
organ
for
carbohydrate
lipid
metabolism,
exhibits
decreased
tolerance
to
hepatic
I/R
patients
with
diabetes
mellitus
(DM),
significant
increase
dysfunction
following
This
may
be
attributed
elevated
oxidative
stress
inflammation.
Our
prior
research
established
sinomenine's
(SIN)
protective
role
against
injury.
Nevertheless,
the
impact
of
SIN
on
injury
DM
rats
remains
unexplored.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 3, 2024
Abstract
Sinoacutine
synthetase
(SinSyn)
is
one
of
the
key
enzymes
in
biosynthesis
pathway
sinomenine
(SIN),
an
effective
pharmacological
component
Sinomenium
acutum.
However,
transcriptional
regulation
mechanism
this
gene
SIN
synthesis
has
not
been
studied.
In
study,
a
1520
bp
upstream
promoter
sequence
and
three
5'
terminal
truncations
were
used
to
drive
GUS
reporter
test
their
activities
transiently
expressed
tobacco
stable
transgenic
Arabidopsis.
Both
full-length
truncated
promoters
can
initiate
GUS
expression.
As
end
removed,
activity
different.
The
results
histochemical
staining
showed
that
−
956
~
-622
was
important
position
SinSyn
promoter.
addition,
bioinformatics
analysis
revealed
various
regions
distributed
with
some
abiotic
stress
plant
hormone
activation.
Through
Arabidopsis
thaliana
verification,
it
confirmed
could
respond
methyl
jasmonate
(MeJA),
auxin
(NAA,
IBA),
drought,
NaCl.
MeJA
response
elements
located
at
-1520
-956
bp,
-395
drought
-1
NaCl
bp.
general,
our
study
provides
theoretical
reference
for
application
pSinSyn
biological
resistance,
functional
verification
gene,
Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 3, 2024
ABSTRACT
Osteoporosis
(OP)
is
a
globally
prevalent
bone
disease
characterized
by
reduced
mass
and
heightened
fracture
risk,
posing
significant
health
economic
challenge
to
aging
societies
worldwide.
Osteoimmunology—an
emerging
field
of
study—investigates
the
intricate
relationship
between
skeletal
immune
systems,
providing
insights
into
system's
impact
on
progression.
Recent
research
has
demonstrated
essential
roles
played
various
cells
(T
cells,
B
macrophages,
dendritic
mast
granulocytes,
innate
lymphoid
cells)
in
regulating
metabolism,
homeostasis,
formation,
remodeling
through
interactions
with
osteoclasts
(OC)
osteoblasts
(OB).
These
findings
underscore
that
osteoimmunology
provides
an
theoretical
framework
for
understanding
pathogenesis
disorders,
including
OP.
Traditional
Chinese
medicine
(TCM)
its
active
ingredients
have
clinical
value
OP
treatment.
Unfortunately,
despite
their
striking
multieffect
pathways
pharmacological
field,
current
not
yet
summarized
them
comprehensive
detailed
manner
respect
interventional
diseases,
especially
Consequently,
this
review
addresses
recent
studies
mechanisms
which
communication
molecules
contribute
development.
Additionally,
it
explores
potential
therapeutic
benefits
TCM
components
treating
from
perspective
osteoimmunology.
The
objective
provide
enhances
immune‐related
diseases
facilitate
development
novel
strategies.
