Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1879(6), P. 189216 - 189216
Published: Nov. 1, 2024
Language: Английский
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 14, 2025
Macrophages are crucial immune cells within the tumor microenvironment (TME), involved in regulating proliferation, invasion, metastasis, ECM remodeling, angiogenesis, and immunosuppression. Although more experimental evidence clinical data indicate that macrophages onset progression of oral squamous cell carcinoma (OSCC), exact pathogenesis OSCC associated with has not been fully elucidated. Enhanced knowledge molecular mechanisms involving will aid creation treatments targeted specifically at macrophages. This review outlines pro-tumoral anti-tumoral effects OSCC, emphasizing interaction between It can provide theoretical basis for establishment complex regulatory network centered on explore novel therapeutic strategies OSCC.
Language: Английский
Citations
1
Heliyon, Journal Year: 2024, Volume and Issue: 10(5), P. e27162 - e27162
Published: Feb. 27, 2024
Individuals diagnosed with head and neck squamous cell carcinoma (HNSCC) experience a significant occurrence rate are susceptible to premature spreading, resulting in bleak outlook. Therapeutic approaches, such as chemotherapy, targeted therapy, immunotherapy, may exhibit primary acquired resistance during the advanced phases of HNSCC. There is currently no viable solution tackle this issue. PANoptosis-a type non-apoptotic death-is recently identified mechanism cellular demise that entails communication synchronization among thermal apoptosis, necrosis mechanisms. However, extent which PANoptosis-associated genes (PRG) contribute forecast immune reaction HNSCC remains mostly undisclosed. The present study aimed thoroughly analyze potential importance PRG report our discoveries. We systematically analyzed 19 from previous studies clinical data patients establish PAN-related signature assess its prognostic, predictive potential. Afterward, patient information was separated into two gene patterns corresponded each other, analysis focused on connection between prognosis, status, cancer immunotherapy. PAN score found correlate survival rates, systems, cancer-related pathways. then validated malignant role CD27 them In summary, we demonstrated effectiveness PAN.Score-based molecular clustering prognostic features predicting outcome discovery made could enhance comprehension significance PAN.Score facilitate development more effective treatment approaches.
Language: Английский
Citations
5
International Immunopharmacology, Journal Year: 2023, Volume and Issue: 126, P. 111200 - 111200
Published: Nov. 20, 2023
Language: Английский
Citations
12
Human Immunology, Journal Year: 2024, Volume and Issue: 85(3), P. 110805 - 110805
Published: May 1, 2024
Epidermolysis bullosa (EB) is an umbrella term for a group of rare inherited skin disorders characterised by mucocutaneous fragility. Patients suffer from blisters and chronic wounds that arise spontaneously or following minor mechanical trauma, often resulting in inflammation, scarring fibrosis due to poor healing. The recessive form dystrophic EB (RDEB) has particularly severe phenotype caused mutations the COL7A1 gene, encoding collagen VII protein, which responsible adhering epidermis dermis together. One most feared devastating complications RDEB development aggressive cutaneous squamous cell carcinoma (cSCC), main cause mortality this patient group. However, pathological drivers behind progression RDEB-associated cSCC (RDEB-cSCC) remain somewhat enigma, evidence date points towards complex process. Currently, there no cure RDEB-cSCC, treatments primarily focus on prevention, symptom management support. Therefore, urgent need comprehensive understanding cancer's pathogenesis, with aim facilitating discovery drug targets. This review explores current knowledge emphasising important role immune system, genetics, fibrosis, tumour-promoting microenvironment, all ultimately intricately interconnected.
Language: Английский
Citations
4
Journal of Dental Sciences, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Nov. 1, 2024
Tumor-associated macrophages (TAMs) are a phenotypically diverse, highly plastic population of cells in the tumor microenvironment (TME) that have long been known to promote cancer progression. In this review, we summarize TAM ontogeny and polarization, then explore how TAMs enhance cell migration through TME, thus facilitating metastasis. We also discuss chemotherapy host factors including diet, obesity, race, impact phenotype brief, induce epithelial-mesenchymal transition (EMT) cells, giving them migratory phenotype. They extracellular matrix (ECM) remodeling, allowing migrate more easily. provide chemotactic signals directional towards blood vessels, participate signaling cascade at vessel allows intravasate disseminate throughout body. Furthermore, while can repolarize an anti-tumor response, these cytotoxic drugs lead macrophage-mediated relapse Patient response may be dependent on patient-specific such as shown alter macrophage affect cancer-related outcomes. More research progression is needed refine treatment strategies for patients.
Language: Английский
Citations
3
Life, Journal Year: 2023, Volume and Issue: 13(7), P. 1577 - 1577
Published: July 18, 2023
Oral squamous cell carcinoma (OSCC) is the most frequent type of oral cancer multifactorial origin, characterized by histological and clinical manifestations. To date, there are no specific biomarkers or treatment modalities available to efficiently manage this neoplasia, demanding further research on molecular background OSCC pathology. Elucidation signal transduction pathways associated molecules with differential expression function in expected enhance future development targeted therapies. Among signaling proteins a potential functional role OSCC, High Mobility Group Box 1 (HMGB1) protein has stimulated scientific interest due upregulation, implication progression many types head neck types. HMGB1 nuclear nonhistone an extracellularly secreted cytokine that can interact several implicated pathogenic OSCC. Binding receptors cells such as receptor AGE (RAGE) toll-like (TLR) been shown initiate intercellular cascades promote growth, invasion, metastasis, indicating target for patient prognosis therapeutic approaches. The purpose review explore order reveal targeting options.
Language: Английский
Citations
7
The Laryngoscope, Journal Year: 2024, Volume and Issue: 134(9), P. 3941 - 3946
Published: March 28, 2024
Objectives Sinonasal inverted papilloma (SNIP) is a noncancerous tumor that develops in the mucous membrane of nasal sinuses. Many malignancies are tightly linked to autophagy, an intracellular self‐degradation mechanism. HMGB1 has demonstrated its ability modulate autophagy many pathological conditions. This work investigates how and other genes involved contribute SNIP. Material Methods The study included 45 patients with SNIP control group consisting 28 individuals. In each group, qPCR was employed examine mRNA expression levels correlated HMGB1. associated were examined for protein via Western Blot immunohistochemical staining assays. At same time, association between discovered through correlation analysis. Furthermore, Krouse staging utilized investigating autophagy‐related at various stages clinically staged patients. Results LC3B, ATG5, Beclin1 substantially expressed Additionally, there positive these genes. During phases SNIP, notably elevated stage T4 compared T2. Conclusion Clinical conjunction Beclin1, suggesting possibility novel prognostic indicators. Level Evidence NA Laryngoscope , 134:3941–3946, 2024
Language: Английский
Citations
1
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1879(3), P. 189105 - 189105
Published: May 1, 2024
Language: Английский
Citations
1
Cytokine & Growth Factor Reviews, Journal Year: 2024, Volume and Issue: 78, P. 85 - 104
Published: July 14, 2024
The high-mobility group box (HMGB) family consists of four DNA-binding proteins that regulate chromatin structure and function. In addition to their intracellular functions, recent studies have revealed involvement as extracellular damage-associated molecular patterns (DAMPs), contributing immune responses tumor development. HMGB promotes tumorigenesis by modulating multiple processes including proliferation, metabolic reprogramming, metastasis, evasion, drug resistance. Due the predominant focus on HMGB1 in literature, little is known about remaining members this family. This review summarizes structural, distributional, well functional similarities distinctions among family, followed a comprehensive exploration roles We emphasize distributional hierarchy at both organizational subcellular levels, with relationship microenvironment (TIME), aiming prospect potential strategies for anticancer therapy.
Language: Английский
Citations
1