Comprehensive analytical chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Future Pharmacology, Journal Year: 2023, Volume and Issue: 3(4), P. 686 - 707
Published: Oct. 8, 2023
Breast cancer is a complex disease for which pharmacological treatment does not guarantee success or cure. In addition, current therapies induce unwanted side effects due to their lack of specificity selectivity. Therefore, it necessary develop new therapeutic options improve these aspects. Currently, phytochemicals with antineoplastic properties have been identified from wide variety plant sources, and developed based on the conjugation drugs polymeric matrices, resulting in nanoparticles hydrogels improved properties. Some conjugated antibodies selectivity specificity. One most important advances breast has development cyclin inhibitors gene therapy. This review provides an overview derived medicinal plants matrices high potential use cancer. We also highlight clinical evidence anti-HER2 monoclonal cancer, as well advantages using antibodies. Finally, we mention some considerations that should be taken into account search agents phytochemicals, polymers, antibodies, inhibitors, therapy focused
Language: Английский
Citations
5
Molecules, Journal Year: 2023, Volume and Issue: 28(23), P. 7890 - 7890
Published: Dec. 1, 2023
Antibodies and their derivatives (scFv, Fabs, etc.) represent a unique class of biomolecules that combine selectivity with the ability to target drug delivery. Currently, one most promising endeavors in this field is development molecular diagnostic tools antibody-based therapeutic agents, including antibody–drug conjugates (ADCs). To meet challenge, it imperative advance methods for modifying antibodies. A particularly strategy involves introduction carbonyl groups into antibody are amenable further modification by biorthogonal reactions, namely aliphatic, aromatic, α-oxo aldehydes, as well aliphatic aryl–alkyl ketones. In review, we summarize preparation applications site-specific synthesized using approach.
Language: Английский
Citations
4
Pharmacy & Pharmacology, Journal Year: 2024, Volume and Issue: 11(5), P. 384 - 398
Published: Jan. 29, 2024
The aim of the work was to conduct an analysis current state and trends in approval drugs, as well some aspects methodology for their development based on biological molecules registration. Materials methods. material taken from abstract databases PubMed, Google Scholar e-library.ru. search carried out using publications period 2008 2023, keywords were follows: “biologicals”, “new drug approval”, “drug authorization”, development”, “biosimilar”, taking into account various spellings. Results. Over past 15 years, scientists have been observing revolutionary processes field development, especially biopharmaceuticals. Significant advances made gene, immune cell therapies, resulting such drugs more than doubling over ten years. includes identification testing molecular targets requires a deep understanding structure functioning polypeptides involved effect. features these active pharmaceutical substances are high weight, complex three-dimensional immunogenic potential. Preclinical clinical studies biologics unique challenges. Selecting appropriate animal species, immunogenicity, assessing pharmacodynamics toxicological properties require multilevel, detailed approach. article discusses regulatory framework under which registered, summarizing guidelines provided by international organizations International Council Harmonization national agencies. Conclusion. highlights prospects biologics, highlighting key role future transformations treatment rare diseases oncology, approaching era personalized medicine. Monitoring directions technological approaches, commitment global methodological can become catalyst Russian pharmacology.
Language: Английский
Citations
1
Published: June 14, 2024
Amino acid sequences of native proteins are generally not palindromic. The protein molecule obtained as a result reading the amino sequence backwards, i.e., retro-protein, having same composition and hydrophobicity profile may behave different molecule. Here we have used R4, directed evolution product Scfv-13, that binds β-galactosidase, report properties retro-R4 (rR4). rR4 remains binding its new target is Glutamine-fructose-6-phosphate aminotransferase (GLMS), E. coli protein. Additionally, tight junction immunoglobulin domain- containing membrane protein, junctional adhesion A (JAMA) retro-protein retains ability to drive cell-cell interactions. Thus, engineering suggests potential application retro-proteins superfamily.
Language: Английский
Citations
1
Emerging Microbes & Infections, Journal Year: 2024, Volume and Issue: 14(1)
Published: Nov. 30, 2024
Infections caused by
Language: Английский
Citations
1
Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 4, 2024
β-Conglycinin is the main allergen present in soybeans, and it causing wide concern due to its notable allergenicity, heat, digestive enzyme resistance. Screening for aptamers that both recognize β-conglycinin inhibit allergic reactions triggers necessary. Conventional aptamer screening labor-intensive, requires skilled personnel, has limited reproducibility. To address these limitations, an automated device was developed enhance efficiency of selection Capture-SELEX. The achieves highly integrated, reproducible, accurate contamination control. Using this device, a high-affinity specific aptamer, β-5, selected with
Language: Английский
Citations
1
eXPRESS Polymer Letters, Journal Year: 2023, Volume and Issue: 18(2), P. 160 - 192
Published: Dec. 6, 2023
Polymer-based hydrogels are hydrophilic polymer networks with a remarkable capacity to absorb substantial amounts of water and biological fluids, rendering them highly attractive for drug delivery applications.The COVID-19 pandemic has acted as catalyst research innovation in the realm polymer-based delivery, particular emphasis on antiviral therapeutics, vaccines, diagnostics, precision respiratory system.The distinctive attributes hydrogels, such their biocompatibility, customizable release profiles, ease functionalization, establish versatile platforms development advanced systems combat not only but also spectrum other infectious diseases.This study is dedicated scruti-nizing evaluating characteristics employed treatment diseases associated SARS-CoV-2 virus.Furthermore, investigation introduces novel classification system deployed SARS-CoV-2-related diseases.Additionally, paper provides an up-to-date evaluation latest developed utilized dis-eases linked virus, based conducted through recent months 2023.
Language: Английский
Citations
1
Journal of Diabetes & Metabolic Disorders, Journal Year: 2024, Volume and Issue: 23(1), P. 323 - 331
Published: Jan. 18, 2024
Language: Английский
Citations
0
BIOspektrum, Journal Year: 2024, Volume and Issue: 30(2), P. 173 - 176
Published: March 1, 2024
Abstract The purification of antibodies from cell cultures is a crucial step in the technical production high-quality for medical, diagnostic and biotechnological applications. Miniaturized chromatographic columns (“RoboColumns”) are used to develop efficient methods. automation entire process using RoboColumn Unit combination with liquid handling platform enables an increase efficiency development procedures.
Language: Английский
Citations
0
Springer briefs in molecular science, Journal Year: 2024, Volume and Issue: unknown, P. 35 - 56
Published: Jan. 1, 2024
Language: Английский
Citations
0