Role of T Helper 1 in COVID-19 Pathogenesis: Foe or Friend DOI Open Access
Mehdi Yolmeh, Reza Ahmadi, Asyeh Yolmeh

et al.

International Journal of Enteric Pathogens, Journal Year: 2023, Volume and Issue: 11(4), P. 140 - 150

Published: Nov. 30, 2023

Cytokines produced by T helper cells (Th cells) have essential roles in the body’s defense against viruses. Inadequate and high levels of specific cytokines can side effects. This literature review article discusses mechanisms Th1 responses SARS-CoV-2 sheds light on pivotal role various inflammatory markers COVID-19-related complications. The latest literary works relevant to this study were carefully chosen evaluated. Extensive searches conducted across multiple databases, such as Scopus, PubMed, Google Scholar, ScienceDirect. After evaluating existing literature, it has been observed that unregulated immune result heightened inflammation. Recent studies provided proof occurrence cytokine storms significantly contribute severity COVID-19, ultimately resulting multi-organ failure loss life. Factors influence cell response its impact COVID-19 include timing response, pre-existing conditions, viral load, genetic susceptibility. Ultimately, effectively managing storm, we potential greatly reduce number deaths caused virus.

Language: Английский

Transcriptomic profiles of monocyte-derived macrophages exposed to SARS-CoV-2 VOCs reveal immune-evasion escape driven by delta DOI Creative Commons
Alessia Gallo, Josè Camilla Sammartino, Roberta Vazzana

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 4, 2025

Since the breakout of COVID-19, mutated forms severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have shown enhanced rates transmission and adaptation to humans. The variants concern (VOC), designated Alpha, Beta, Gamma, Delta, Omicron emerged independent one another, in turn rapidly became dominant. success each VOC, as well virus fitness, were enabled by altered intrinsic functional properties and, reasonably, antigenicity changes, conferring ability evade a primed immune response. We analysed gene expression profiles monocyte-derived macrophages (MDM) isolated from whole blood healthy participants exposed 5 different SARS-CoV-2 VOC: D614G, Alpha (B.1.1.7), Gamma (P1), Delta (B.1.617.2), BA.1 (B.1.1.529), HCoV-OC43 strain, already present population before pandemic. Whole transcriptome RNA-Seq, for both coding non-coding RNAs, was then made. After exposure VOC MDM, we initially assessed presence viral transcripts confirm entry. RNA-Seq data observed significant deregulation RNAs. In particular, our analysis showed up-regulation several genes involved immunological processes, such PARP9/PARP14 axes, variants. Surprisingly, that variant exhibited transcriptional profile more similar naïve control group, while intermediate differentially expressed (DEGs) between two groups. By checking canonical markers M1/M2 differentiation states, did not observe any variant, suggesting an M0 status, comparable group. Finally, 3 main types RNAs (ncRNAs): long (lncRNAs), microRNAs (miRNAs), small nucleolar (snoRNAs), some which are common coronaviruses, specific SARS-CoV-2. SARS-CoV-2-dependent alteration macrophage (MDM)-infected cells can be linked chronological order variants' appearance human population. Our suggest evolution modulating host response, with strong change pace beginning advent variant. MDMs failure activation adaptive this correlates symptoms developed people affected

Language: Английский

Citations

1
Cationic liposomes encapsulating IL-2 selectively induce apoptosis and significantly reduce the secretion of cytokines on M1-murine polarized macrophages DOI Creative Commons
Carlos Adrián Vargas-Ángeles, Leonardo Trujillo-Cirilo, Edith Sierra-Mondragón

et al.

Cytokine, Journal Year: 2025, Volume and Issue: 189, P. 156903 - 156903

Published: Feb. 28, 2025

Language: Английский

Citations

0
SARS-CoV-2 nucleocapsid protein induces a Mincle-dependent macrophage inflammatory response in acute kidney injury DOI

Ruizhi Tan,

Wenjing Zhao, Jing Gao

et al.

Inflammation Research, Journal Year: 2025, Volume and Issue: 74(1)

Published: April 17, 2025

Language: Английский

Citations

0
Angiotensin-(1–7) decreases inflammation and lung damage caused by betacoronavirus infection in mice DOI
Érick Bryan de Sousa Lima, Antônio Felipe Silva Carvalho, Isabella Zaidan

et al.

Inflammation Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 18, 2024

Language: Английский

Citations

2
The role of epithelial-mesenchymal transition in pulmonary fibrosis: lessons from idiopathic pulmonary fibrosis and COVID-19 DOI Creative Commons

Reyhaneh Niayesh‐Mehr,

Mojtaba Kalantar, Giulio Bontempi

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 13, 2024

Despite the tremendous advancements in knowledge of pathophysiology and clinical aspects SARS-CoV-2 infection, still many issues remain unanswered, especially long-term effects. Mounting evidence suggests that pulmonary fibrosis (PF) is one most severe complications associated with COVID-19. Therefore, understanding molecular mechanisms behind its development helpful to develop successful therapeutic strategies. Epithelial mesenchymal transition (EMT) cell specific variants endothelial (EndMT) mesothelial (MMT) are physio-pathologic cellular reprogramming processes induced by several infectious, inflammatory biomechanical stimuli. Cells undergoing EMT acquire invasive, profibrogenic proinflammatory activities secreting extracellular mediators. Their activity has been implicated pathogenesis PF a variety lung disorders, including idiopathic (IPF) Aim this article provide an updated survey mechanisms, emphasis on EMT-related processes, genesis IFP

Language: Английский

Citations

2
Hypotensive drugs mitigate the high-sodium diet-induced pro-inflammatory activation of mouse macrophages in vivo DOI Open Access
Martyna Cieślik,

Spencer Strobel,

Paweł Bryniarski

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116648 - 116648

Published: April 26, 2024

Nowadays, there is an increasing emphasis on the need to alleviate chronic inflammatory response effectively treat hypertension. However, are still gaps in our understanding how achieve this. Therefore, research interaction of antihypertensive drugs with immune system extremely interesting, since their therapeutic effect could partly result from amelioration hypertension-related inflammation, which macrophages seem play a pivotal role. Thus, current comprehensive studies have investigated impact repeatedly administered hypotensive (captopril, olmesartan, propranolol, carvedilol, amlodipine, verapamil) macrophage functions innate and adaptive immunity, as well if drug-induced effects affected by high-sodium diet (HSD), one key environmental risk factors Although assayed medications increased generation reactive oxygen nitrogen intermediates standard fed donors, they reversed HSD-induced enhancing oxidative burst secretion pro-inflammatory cytokines. On other hand, some phagocytic activity expression surface markers involved antigen presentation, translated into enhanced ability activate B cells for antibody production. Moreover, augmented function effector phase contact hypersensitivity reaction, but suppressed sensitization cell-mediated under HSD conditions. Our findings contribute recognition mechanisms, excessive sodium intake affects hypertensive individuals, provide evidence that mitigate most adverse effects, suggesting additional protective activity.

Language: Английский

Citations

1
SARS-CoV-2 Modulation of HIV Latency Reversal in a Myeloid Cell Line: Direct and Bystander Effects DOI Creative Commons

Patricio Jarmoluk,

Franco Agustín Sviercz,

Cintia Cevallos

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(8), P. 1310 - 1310

Published: Aug. 17, 2024

Coronavirus disease 2019 (COVID-19) might impact progression in people living with HIV (PLWH), including those on effective combination antiretroviral therapy (cART). These individuals often experience chronic conditions characterized by proviral latency or low-level viral replication CD4+ memory T cells and tissue macrophages. Pro-inflammatory cytokines, such as TNF-α, IL-1β, IL-6, IFN-γ, can reactivate provirus expression both primary cell lines. cytokines are elevated infected SARS-CoV-2, the virus causing COVID-19. However, it is still unknown whether SARS-CoV-2 modulate reactivation cells. Here, we report that exposure of chronically HIV-1-infected myeloid line U1 to two different isolates (ancestral BA.5) reversed its latent state after 24 h. We also observed human monocyte-derived macrophages (MDM) initially drove their polarization towards an M1 phenotype, which shifted M2 over time. This effect was associated soluble factors released during initial phase reactivated production cells, like MDM stimulated TLR agonist resiquimod. Our study suggests SARS-CoV-2-induced systemic inflammation interaction could influence HIV-1 PLWH.

Language: Английский

Citations

1
Angiotensin-(1-7) decreases inflammation and lung damage caused by betacoronavirus infection in mice DOI Creative Commons
Érick Bryan de Sousa Lima, Antônio Felipe Silva Carvalho, Isabella Zaidan

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 18, 2024

Abstract Objective: Pro-resolving molecules, including the peptide Angiotensin-(1-7) [Ang-(1-7)], have potential adjunctive therapy for infections. Here we evaluate actions of Ang-(1-7) in betacoronavirus infection mice. Methods: C57BL/6 mice were infected intranasally with murine MHV-3 and K18-hACE2 SARS-CoV-2. Mice treated (30 μg/mouse, i.p.) at 24-, 36-, 48-hours post-infection (hpi) or 24, 36, 48, 72, 96 h. For lethality evaluation, one additional dose was given 120 hpi. At 3- 5-days post- (dpi) blood cell, inflammatory mediators, viral loads, lung histopathology evaluated. Results: Ang-(1-7) rescued lymphopenia MHV-infected mice, decreased airways leukocyte infiltration damage 5-dpi. The levels pro-inflammatory cytokines virus titers plasma by during MHV infection. improved function increased survival rates Notably, treatment SARS-CoV-2 restored lymphocytes to baseline, weight loss, titters cytokines, resulting improvement pulmonary clinical scores. Conclusion: protected from death infections modulating inflammation, hematological parameters enhancing clearance.

Language: Английский

Citations

0
Role of T Helper 1 in COVID-19 Pathogenesis: Foe or Friend DOI Open Access
Mehdi Yolmeh, Reza Ahmadi, Asyeh Yolmeh

et al.

International Journal of Enteric Pathogens, Journal Year: 2023, Volume and Issue: 11(4), P. 140 - 150

Published: Nov. 30, 2023

Cytokines produced by T helper cells (Th cells) have essential roles in the body’s defense against viruses. Inadequate and high levels of specific cytokines can side effects. This literature review article discusses mechanisms Th1 responses SARS-CoV-2 sheds light on pivotal role various inflammatory markers COVID-19-related complications. The latest literary works relevant to this study were carefully chosen evaluated. Extensive searches conducted across multiple databases, such as Scopus, PubMed, Google Scholar, ScienceDirect. After evaluating existing literature, it has been observed that unregulated immune result heightened inflammation. Recent studies provided proof occurrence cytokine storms significantly contribute severity COVID-19, ultimately resulting multi-organ failure loss life. Factors influence cell response its impact COVID-19 include timing response, pre-existing conditions, viral load, genetic susceptibility. Ultimately, effectively managing storm, we potential greatly reduce number deaths caused virus.

Language: Английский

Citations

0