International Immunopharmacology, Journal Year: 2024, Volume and Issue: 146, P. 113914 - 113914
Published: Dec. 27, 2024
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Oct. 14, 2024
Iron, an essential mineral in the body, is involved numerous physiological processes, making maintenance of iron homeostasis crucial for overall health. Both overload and deficiency can cause various disorders human diseases. Ferroptosis, a form cell death dependent on iron, characterized by extensive peroxidation lipids. Unlike other kinds classical unprogrammed death, ferroptosis primarily linked to disruptions metabolism, lipid peroxidation, antioxidant system imbalance. Ferroptosis regulated through transcription, translation, post-translational modifications, which affect cellular sensitivity ferroptosis. Over past decade or so, diseases have been as part their etiology, including cancers, metabolic disorders, autoimmune diseases, central nervous cardiovascular musculoskeletal Ferroptosis-related proteins become attractive targets many major that are currently incurable, some regulators shown therapeutic effects clinical trials although further validation potential needed. Therefore, in-depth analysis its molecular mechanisms may offer additional strategies prevention treatment. In this review, we discuss significance contribution etiology development along with evidence supporting targeting approach. Importantly, evaluate recent promising interventions, providing guidance future targeted treatment therapies against
Language: Английский
Citations
60
Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 395 - 395
Published: March 26, 2024
Central neurological disorders are significant contributors to morbidity, mortality, and long-term disability globally in modern society. These encompass neurodegenerative diseases, ischemic brain traumatic injury, epilepsy, depression, more. The involved pathogenesis is notably intricate diverse. Ferroptosis neuroinflammation play pivotal roles elucidating the causes of cognitive impairment stemming from these diseases. Given concurrent occurrence ferroptosis due metabolic shifts such as iron ROS, well their critical central nervous disorders, investigation into co-regulatory mechanism has emerged a prominent area research. This paper delves mechanisms along with interrelationship. It specifically emphasizes core molecules within shared pathways governing neuroinflammation, including SIRT1, Nrf2, NF-κB, Cox-2, iNOS/NO·, how different immune cells structures contribute dysfunction through mechanisms. Researchers’ findings suggest that mutually promote each other may represent key factors progression disorders. A deeper comprehension common pathway between cellular holds promise for improving symptoms prognosis related
Language: Английский
Citations
18
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7461 - 7461
Published: July 7, 2024
Osteoarthritis (OA) is the most common joint disease, causing symptoms such as pain, swelling, and deformity, which severely affect patients' quality of life. Despite advances in medical treatment, OA management remains challenging, necessitating development safe effective drugs. Quercetin (QUE), a natural flavonoid widely found fruits vegetables, shows promise due to its broad range pharmacological effects, particularly various degenerative diseases. However, role preventing progression underlying mechanisms remain unclear. In this study, we demonstrated that QUE has protective effect against both vivo vitro, elucidated molecular mechanisms. inhibited expression IL-1β-induced chondrocyte matrix metalloproteinases (MMP3 MMP13) inflammatory mediators INOS COX-2. It also promoted collagen II, thereby extracellular (ECM). Mechanistically, exerts on chondrocytes by activating SIRT1/Nrf-2/HO-1 inhibiting ferroptosis. Similarly, an rat model induced anterior cruciate ligament transection (ACLT), treatment improved articular cartilage damage, reduced normalized abnormal subchondral bone remodeling. serum IL-1β, TNF-α, MMP3, CTX-II, COMP, slowing OA. chondroprotective effects oxidative damage ferroptosis through pathway, effectively alleviating rats.
Language: Английский
Citations
11
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown
Published: June 4, 2024
Language: Английский
Citations
6
Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 733, P. 150683 - 150683
Published: Sept. 10, 2024
Language: Английский
Citations
4
Journal of Bone and Mineral Metabolism, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 9, 2025
Language: Английский
Citations
0
Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13
Published: March 5, 2025
Ferroptosis is a novel form of cell death that uniquely requires iron and characterized by accumulation, the generation free radicals leading to oxidative stress, formation lipid peroxides, which distinguish it from other forms death. The regulation ferroptosis extremely complex closely associated with spectrum diseases. Sirtuin 1 (SIRT1), NAD + -dependent histone deacetylase, has emerged as pivotal epigenetic regulator potential regulate through wide array genes intricately metabolism, homeostasis, glutathione biosynthesis, redox homeostasis. This review provides comprehensive overview specific mechanisms SIRT1 regulates explores its therapeutic value in context multiple disease pathologies, highlighting significance SIRT1-mediated treatment strategies.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8212 - 8212
Published: July 27, 2024
Ferroptosis is a form of iron-dependent regulated cell death caused by the accumulation lipid peroxides. In this review, we summarize research on impact ferroptosis disease models and isolated cells in various types arthritis. While most studies have focused rheumatoid arthritis (RA) osteoarthritis (OA), there limited spondylarthritis crystal arthropathies. The effects inducing or inhibiting strongly depend studied type. search for new therapeutic targets, chondrocytes might promising any type On other hand, induction may also lead to desired decrease synovial fibroblasts RA. Thus, must consider cell-type-specific Further investigation needed clarify these complexities.
Language: Английский
Citations
3
Chinese Medical Journal, Journal Year: 2024, Volume and Issue: 137(14), P. 1651 - 1662
Published: June 12, 2024
Abstract Iron is indispensable for the viablility of nearly all living organisms, and it imperative cells, tissues, organisms to acquire this essential metal sufficiently maintain its metabolic stability survival. Disruption iron homeostasis can lead development various diseases. There a robust connection between metabolism infection, immunity, inflammation, aging, suggesting that disorders in may contribute pathogenesis arthritis. Numerous studies have focused on significant role arthritis potential targeted drug therapy. Targeting offers promising approach individualized treatment Therefore, review aimed investigate mechanisms by which body maintains impacts Furthermore, identify therapeutic targets active substances related metabolism, could provide research directions field.
Language: Английский
Citations
2
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 140, P. 112741 - 112741
Published: Aug. 1, 2024
Language: Английский
Citations
1