A Double Network Composite Hydrogel with Self-Regulating Cu²⁺/Luteolin Release and Mechanical Modulation for Enhanced Wound Healing

ACS Nano, Journal Year: 2024, Volume and Issue: 18(26), P. 17251 - 17266

Published: June 22, 2024

Designing adaptive and smart hydrogel wound dressings to meet specific needs across different stages of healing is crucial. Here, we present a composite hydrogel, GSC/PBE@Lut, that offers self-regulating release cupric ions luteolin modulates mechanical properties promote chronic healing. The double network GSC, fabricated through photo-cross-linking gelatin methacrylate, followed by Cu2+-alginate coordination cross-linking. On one hand, GSC allows for rapid Cu2+ eliminate bacteria in the acidic pH environment during inflammation reduces hydrogel's strength minimize tissue trauma early dressing changes. other enables slow proliferation stage, promoting angiogenesis biocompatibility. Furthermore, inclusion pH- reactive oxygen species (ROS)-responsive nanoparticles (PBE@Lut) matrix controlled luteolin, offering antioxidant anti-inflammatory effects macrophage polarization. In murine model Staphylococcus aureus infected wounds, GSC/PBE@Lut demonstrates exceptional therapeutic benefits antibacterial, anti-inflammatory, angiogenic, regeneration. Overall, our results suggest hydrogels with bioactive agent modulation promising solution treating wounds.

Language: Английский

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Autophagy: A potential target for natural products in the treatment of ulcerative colitis

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116891 - 116891

Published: June 12, 2024

Ulcerative colitis (UC) is a chronic inflammatory bowel disease primarily affecting the mucosa of colon and rectum. UC characterized by recurrent episodes, often necessitating lifelong medication use, imposing significant burden on patients. Current conventional advanced treatments for have disadvantages insufficient efficiency, susceptibility to drug resistance, notable adverse effects. Therefore, developing effective safe drugs has become an urgent need. Autophagy intracellular degradation process that plays important role in intestinal homeostasis. Emerging evidence suggests aberrant autophagy involved development UC, modulating can effectively alleviate experimental colitis. A growing number studies established interplay with endoplasmic reticulum stress, gut microbiota, apoptosis, NLRP3 inflammasome, all which contribute pathogenesis UC. In addition, variety epithelial cells, including absorptive goblet Paneth as well other cell types like neutrophils, antigen-presenting stem cells gut, mediate through autophagy. To date, many found natural products hold potential exert therapeutic effects regulating This review focuses possible pharmacological mechanisms target recent years, aiming provide basis new development.

Language: Английский

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Luteolin attenuates cadmium neurotoxicity by suppressing glial inflammation and supporting neuronal survival

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 152, P. 114406 - 114406

Published: March 10, 2025

Language: Английский

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Gut Microbiota and Inflammation Modulation in a Rat Model for Ulcerative Colitis after the Intraperitoneal Administration of Apigenin, Luteolin, and Xanthohumol

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3236 - 3236

Published: March 12, 2024

Ulcerative colitis (UC) is a chronic inflammatory disorder affecting the colon, with symptomatology influenced by factors including environmental, genomic, microbial, and immunological interactions. Gut microbiota dysbiosis, characterized bacterial population alterations, contributes to intestinal homeostasis disruption aberrant immune system activation, thereby exacerbating state. This study assesses therapeutic efficacy of intraperitoneal (IP) injected flavonoids (apigenin, luteolin, xanthohumol) in reduction parameters modulation gut murine model ulcerative colitis. Flavonoids interact modulating their composition serving as substrates for fermentation into other anti-inflammatory bioactive compounds. Our results demonstrate effectiveness luteolin xanthohumol treatment enhancing relative abundance microorganisms, attenuating pro-inflammatory species. Moreover, all three exhibit cytokine levels, strongly demonstrating utility alleviating associated physical UC symptoms. suggests that this molecule potential alternative or co-therapy conventional pharmacological interventions, potentially mitigating adverse effects. A limited impact on observed apigenin, attributed its solubility constraints via chosen administration route, resulting accumulation mesentery.

Language: Английский

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The role and therapeutic targeting of the CCL2/CCR2 signaling axis in inflammatory and fibrotic diseases

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 9, 2025

CCL2, a pivotal cytokine within the chemokine family, functions by binding to its receptor CCR2. The CCL2/CCR2 signaling pathway plays crucial role in development of fibrosis across multiple organ systems modulating recruitment and activation immune cells, which turn influences progression fibrotic diseases liver, intestines, pancreas, heart, lungs, kidneys, other organs. This paper introduces biological CCL2 CCR2, highlighting their similarities differences concerning disorders various systems, reviews recent progress diagnosis treatment clinical linked pathway. Additionally, further in-depth research is needed explore significance axis conditions affecting different

Language: Английский

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The effects of Fraxini cortex and Andrographis herba on Escherichia coli-induced diarrhea in chicken

Poultry Science, Journal Year: 2025, Volume and Issue: 104(2), P. 104824 - 104824

Published: Jan. 16, 2025

Language: Английский

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Luteolin in Inflammatory Bowel Disease and Colorectal Cancer: A Disease Continuum Perspective

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 126 - 126

Published: Feb. 14, 2025

Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory condition that may progress to colorectal cancer (CRC), presenting significant challenges global health. With shifts in lifestyle, the incidence of both conditions continues rise, underscoring urgent need for effective treatments. While traditional therapies can be effective, their high recurrence rates and associated adverse reactions limit broader application. Luteolin, flavonoid derived from natural plants, has emerged as promising focus IBD CRC research due its multi-target therapeutic potential. This article reviews molecular mechanisms signaling pathways through which luteolin regulates immune cell differentiation, mitigates inflammation oxidative stress, modulates gut microbiota, restores mucosal barrier function IBD. In context CRC, demonstrates anti-tumor effects by inhibiting proliferation, inducing apoptosis, suppressing migration invasion. Notably, demonstrated improvements symptoms influencing differentiation T subsets, decreasing expression mediators, activating antioxidant pathways, enhancing structure microbiota. Furthermore, advancements formulation technology, such use polymer micelles responsive nanoparticles, have greatly improved bioavailability efficacy luteolin. However, further investigation needed address potential toxicity luteolin, particularly critical transition CRC. emphasizes treatment anticipates prospects future clinical applications agent.

Language: Английский

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Targeting ferroptosis in the treatment of ulcerative colitis by traditional Chinese medicine: A novel therapeutic strategies

Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156539 - 156539

Published: Feb. 17, 2025

Language: Английский

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Adipose-Derived Mesenchymal Stem Cell Exosomes Encapsulating siIL1R2 Facilitate the Repair of DSS-Induced Intestinal Mucosal Injury

Immunological Investigations, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: March 4, 2025

Interleukin-1 receptor 2 (IL1R2) and C-C motif chemokine (CCR2) as critical mediators of immune modulation inflammation. This study aims to evaluate their functions in dextran sulfate sodium (DSS)-induced intestinal injury. A DSS-induced injury model was established C57BL/6 mice. Pharmacological inhibitors targeting IL1R2 or CCR2 were administered. Adipose-derived mesenchymal stem cell (ADMSC)-derived exosomes isolated loaded with IL1R2-siRNA, which then administered epithelial cells (IEC-6) DSS-challenged upregulated DSS-treated colon tissues. inhibition improved body weight, restored length, reduced serum TNF-α IL-6 levels, preserved integrity miR-128-3p enriched ADMSC-derived significantly expression IEC-6 cells. Further loading an siRNA these led a simultaneous IL1R2. These lipopolysaccharide-induced apoptosis inflammation histological outcomes are key Dual holds great promise for alleviating inflammatory responses improving presentations bowel disease.

Language: Английский

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Regulation of Inflammatory Cytokines and Activation of PI3K/Akt Pathway by Yiqi Jiedu Formula in HSV-1-Induced Keratitis: Experimental and Network Pharmacology Evidence

Virus Research, Journal Year: 2025, Volume and Issue: unknown, P. 199561 - 199561

Published: March 1, 2025

Language: Английский

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