Regulatory roles of noncanonical inflammasomes in kidney diseases
International Immunopharmacology,
Journal Year:
2025,
Volume and Issue:
157, P. 114787 - 114787
Published: May 3, 2025
Language: Английский
The Inhibitory Effects of Maclurin on Fatty Acid Synthase and Adipocyte Differentiation
Ji Young Hwang,
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Hyeon Hak Jeong,
No information about this author
Ji-won Baek
No information about this author
et al.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(16), P. 8579 - 8579
Published: Aug. 6, 2024
Obesity
is
a
complex
health
condition
characterized
by
excessive
adipose
tissue
accumulation,
leading
to
significant
metabolic
disturbances
such
as
insulin
resistance
and
cardiovascular
diseases.
Fatty
acid
synthase
(FAS),
key
enzyme
in
lipogenesis,
has
been
identified
potential
therapeutic
target
for
obesity
due
its
role
adipocyte
differentiation
lipid
accumulation.
This
study
employed
multidisciplinary
approach
involving
silico
vitro
analyses
investigate
the
anti-adipogenic
properties
of
maclurin,
natural
phenolic
compound
derived
from
Language: Английский
Quercetin Ameliorates Acute Lethal Sepsis in Mice by Inhibiting Caspase-11 Noncanonical Inflammasome in Macrophages
Molecules,
Journal Year:
2024,
Volume and Issue:
29(24), P. 5900 - 5900
Published: Dec. 13, 2024
Quercetin
is
a
natural
polyphenolic
flavonoid
widely
found
in
plants,
fruits,
and
vegetables,
has
been
reported
to
play
pharmacological
roles
numerous
pathogenic
conditions.
The
anti-inflammatory
effects
of
quercetin
various
inflammatory
conditions
diseases
have
well-documented.
However,
its
regulatory
role
noncanonical
inflammasome
activation
not
yet
demonstrated.
This
study
investigated
the
caspase-11
inflammasome-activated
responses
macrophages
mouse
model
acute
lethal
sepsis.
protected
J774A.1
from
lipopolysaccharide
(LPS)-induced
cell
death
inflammasome-induced
pyroptosis.
It
significantly
decreased
production
mRNA
expression
pro-inflammatory
cytokines,
such
as
interleukin
(IL)-1β,
IL-18,
IL-6,
but
tumor
necrosis
factor
(TNF)-α,
molecules,
nitric
oxide
(NO)
inducible
NO
synthase
cells.
Mechanistically,
strongly
suppressed
autoproteolysis
secretion
proteolysis
gasdermin
D
did
inhibit
direct
binding
LPS.
In
vivo,
revealed
that
increased
survival
rate
mice
with
sepsis
serum
levels
cytokines
without
causing
significant
toxicity.
conclusion,
this
highlights
quercetin-mediated
action
through
novel
mechanism
targets
macrophages,
suggesting
promising
agent
medicine.
Language: Английский
Regulatory Roles of Noncanonical Inflammasomes in Inflammatory Lung Diseases
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
26(1), P. 27 - 27
Published: Dec. 24, 2024
The
inflammatory
response
consists
of
two
stages:
priming
and
triggering.
triggering
stage
is
marked
by
the
activation
inflammasomes,
which
are
cytosolic
protein
complexes
acting
as
platforms
for
inflammation.
Inflammasomes
divided
into
canonical
noncanonical
categories.
Inflammatory
lung
diseases
such
asthma,
chronic
obstructive
pulmonary
disease
(COPD),
acute
respiratory
distress
syndrome
(ARDS),
injury,
fibrosis
arise
from
inflammation
damage.
While
role
inflammasomes
in
these
well
demonstrated,
recent
findings
emphasize
critical
roles
regulating
various
conditions.
Particularly,
new
studies
highlight
their
involvement
diseases.
This
review
delves
research
on
regulatory
human
caspase-4
murine
caspase-11,
development
diseases,
potential
targeting
treatments.
Language: Английский