Molecules,
Journal Year:
2024,
Volume and Issue:
29(19), P. 4729 - 4729
Published: Oct. 7, 2024
Cancer
is
a
global
health
challenge
with
rising
incidence
and
mortality
rates,
posing
significant
concerns.
The
World
Health
Organization
reports
cancer
as
leading
cause
of
death
worldwide,
contributing
to
nearly
one
in
six
deaths.
pathogenesis
involves
disruptions
cellular
signaling
pathways,
resulting
uncontrolled
cell
growth
metastasis.
Among
emerging
players
biology,
Transient
Receptor
Potential
(TRP)
channels,
notably
TRPV1,
have
garnered
attention
due
their
altered
expression
cells
roles
tumorigenesis
progression.
also
known
the
capsaicin
receptor,
pivotal
pain
mediation,
offering
promise
therapeutic
target.
Activation
TRPV1
triggers
calcium
influx
affects
linked
death.
Additionally,
implicated
cancer-induced
chemo-sensitivity,
upregulation
observed
sensory
neurons
innervating
oral
cancers.
Also,
when
capsaicin,
compound
from
chili
peppers,
interacts
it
elicits
"hot"
sensation
influences
processes
through
influx.
Understanding
TRPV1's
multifaceted
may
lead
novel
strategies
for
managing
cancer-related
symptoms
improving
patient
outcomes.
current
review
elucidates
comprehensive
role
therapy,
particularly
channel,
highlighting
its
effects
various
via
different
pathways
discussing
limitations.
Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: Nov. 26, 2024
Colorectal
cancer
(CRC)
remains
one
of
the
most
prevalent
and
fatal
malignancies
worldwide,
consistently
ranking
among
top
three
in
terms
incidence
mortality.
Despite
notable
advancements
early
detection
therapeutic
interventions,
survival
outcomes
for
advanced-stage
CRC
are
still
dismal,
largely
due
to
issues
such
as
drug
resistance
metastasis.
Recent
research
has
increasingly
implicated
JAK-STAT
signaling
pathway
a
pivotal
contributor
pathogenesis.
This
evolutionarily
conserved
plays
key
role
transmitting
extracellular
signals
nucleus,
thereby
modulating
gene
expression
involved
numerous
fundamental
biological
processes.
In
CRC,
dysregulation
is
frequently
observed
strongly
associated
with
tumor
progression,
including
processes
cellular
proliferation,
apoptosis,
metastasis,
immune
evasion,
sustenance
stem
cells.
Given
its
integral
advancement,
gained
recognition
viable
target.
Extensive
evidence
from
preclinical
clinical
models
supports
efficacy
safety
targeting
components
pathway,
presenting
new
possibilities
patients
particularly
addressing
enhancing
treatment
outcomes.
review
offers
detailed
exploration
focusing
on
regulatory
mechanisms
CRC-related
malignancies.
Moreover,
it
examines
association
between
protein
expression,
features,
prognosis,
potential
management.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 9, 2024
Abstract
Ovarian
cancer
is
the
deadliest
gynecological
malignancy,
owing
to
its
late-stage
diagnosis
and
high
rates
of
recurrence
resistance
following
standard-of-care
treatment,
highlighting
need
for
novel
treatment
approaches.
Through
an
unbiased
drug
screen,
we
identified
kinase
inhibitor,
lestaurtinib,
as
a
potent
antineoplastic
agent
chemotherapy-
PARP-inhibitor
(PARPi)-sensitive
-resistant
ovarian
cells
patient
derived
xenografts
(PDXs).
RNA-sequencing
revealed
that
lestaurtinib
potently
suppressed
JAK/STAT
signaling
efficacy
was
shown
be
directly
related
pathway
activity
in
cell
lines
PDX
models.
Most
exhibited
constitutive
activation
genetic
loss
STAT1
STAT3
resulted
growth
inhibition.
Lestaurtinib
also
displayed
synergy
when
combined
with
cisplatin
olaparib,
including
model
PARPi
resistance.
In
contrast,
most
well-known
ruxolitinib,
lacked
against
all
models
tested.
This
divergent
behavior
reflected
ability
block
both
Y701/705
S727
phosphorylation
STAT3,
whereas
ruxolitinib
failed
S727.
Consistent
these
findings,
additionally
inhibited
JNK
ERK
activity,
leading
more
complete
suppression
STAT
phosphorylation.
Concordantly,
combinatorial
or
inhibitor
synergistic
effects
at
dose
levels
where
single
agents
were
ineffective.
Taken
together,
findings
indicate
other
treatments
converge
on
signaling,
are
worthy
further
pre-clinical
clinical
exploration
highly
aggressive
advanced
forms
cancer.
Statement
significance
cancer,
PARPi-resistant
models,
acts
through
robust
inhibition
synergizes
clinically
relevant
concentrations.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(19), P. 4729 - 4729
Published: Oct. 7, 2024
Cancer
is
a
global
health
challenge
with
rising
incidence
and
mortality
rates,
posing
significant
concerns.
The
World
Health
Organization
reports
cancer
as
leading
cause
of
death
worldwide,
contributing
to
nearly
one
in
six
deaths.
pathogenesis
involves
disruptions
cellular
signaling
pathways,
resulting
uncontrolled
cell
growth
metastasis.
Among
emerging
players
biology,
Transient
Receptor
Potential
(TRP)
channels,
notably
TRPV1,
have
garnered
attention
due
their
altered
expression
cells
roles
tumorigenesis
progression.
also
known
the
capsaicin
receptor,
pivotal
pain
mediation,
offering
promise
therapeutic
target.
Activation
TRPV1
triggers
calcium
influx
affects
linked
death.
Additionally,
implicated
cancer-induced
chemo-sensitivity,
upregulation
observed
sensory
neurons
innervating
oral
cancers.
Also,
when
capsaicin,
compound
from
chili
peppers,
interacts
it
elicits
"hot"
sensation
influences
processes
through
influx.
Understanding
TRPV1's
multifaceted
may
lead
novel
strategies
for
managing
cancer-related
symptoms
improving
patient
outcomes.
current
review
elucidates
comprehensive
role
therapy,
particularly
channel,
highlighting
its
effects
various
via
different
pathways
discussing
limitations.
