France libre Iran., Journal Year: 2024, Volume and Issue: 12(4), P. 127 - 128
Published: Dec. 1, 2024
Language: Английский
Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 165 - 165
Published: Jan. 23, 2025
Chronic pain and mental health disorders, such as depression anxiety, frequently co-occur share underlying mechanisms involving neuronal excitability synaptic transmission. The inwardly rectifying potassium channel 4.1 (Kir4.1), predominantly expressed in glial cells, is crucial for maintaining extracellular glutamate homeostasis. Dysregulation of Kir4.1 leads to altered activity, contributing both chronic disorders. In pain, downregulation impairs buffering clearance, increasing enhancing signaling through peripheral central sensitization. impaired function disrupts neurotrophic factor secretion neuroinflammatory pathways, leading mood disturbances. This review primarily summarizes findings from preclinical studies examine the relationship between pathogenesis discussing its molecular structure, expression patterns, functional roles. Furthermore, we explore therapeutic strategies targeting Kir4.1, including pharmacological modulators gene therapy approaches, emphasizing potential a novel target.
Language: Английский
Citations
1
Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16
Published: March 10, 2025
Endometriosis, the most prevalent cause of infertility, is associated with anatomical distortion leading to adhesions and fibrosis, as well endocrine abnormalities immune disorders. This review discusses mechanisms underlying endometriosis-related infertility. Firstly, alterations in hypothalamic-pituitary-ovarian axis lead secretion gonadotropins steroid hormones, adverse effects on ovulation implantation, fertility decline. Secondly, dysregulation hypothalamic-pituitary-adrenal induces elevated serum cortisol prolactin levels patients endometriosis, accounting for its regulation stress, depression, anxiety. Abnormal interactions between endometrial cells system change local microenvironment, resulting epithelial-mesenchymal transition inflammation. Activated epithelial cells, stromal immunocytes produce various chemokines, cytokines, or autoantibodies, creating an unfavorable environment embryo implantation. These findings suggest that spectrum play a crucial role Thirdly, oxidative stress has ovarian reserve subsequent embryonic development, predicting another promising strategy An unbalanced redox state, including impaired mitochondrial function, dysregulated lipid metabolism, iron-induced generates pro-oxidative which negatively impacts oocyte quality sperm viability. Thus, updated understanding involved this disease will help develop effective strategies manage
Language: Английский
Citations
1
Frontiers in Genetics, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 3, 2025
Endometriosis, a prevalent chronic gynecological condition, is frequently associated with infertility and pelvic pain. Despite numerous studies indicating correlation between epigenetic regulation endometriosis, its precise genetic etiology remains elusive. Methyltransferase-like 14 (METTL14), crucial component of the N6-methyladenosine (m6A) RNA methyltransferase complex an binding scaffold, known to play pivotal role in various human diseases. The possibility that single nucleotide polymorphisms (SNPs) METTL14 gene contribute susceptibility endometriosis has not been thoroughly investigated. We assessed genotype frequencies five potential functional SNPs (rs298982 G>A, rs62328061A>G, rs9884978G>A, rs4834698C>T, rs1064034A>T) Chinese population consisting 458 patients ovarian 462 healthy controls. employed unconditional logistic regression stratified analyses evaluate their genotypic associations risk endometriosis. Among examined, we found rs298982 A allele was significantly increased risk, whereas rs62328061 G linked decreased Individuals harboring two unfavorable genotypes demonstrated elevated (adjusted odds ratio (AOR) = 1.57, 95% confidence interval (CI) 1.16-2.13, P 0.004) compared those no genotypes. Stratified analysis revealed effect GA/AA gravidity≤1, parity≤1, rASRM stage I, II + III IVsubgroups. Haplotype showed individuals GATAA haplotype were at higher (AOR 5.54, CI 1.63-18.87, 0.006), AGTTG exhibited protective effects 0.55, 0.31-0.97, 0.039) wild-type GACAG carriers. Additionally, Bayesian false discovery probability positive report confirmed robustness significant findings. Expression quantitative trait loci association rs9884978 mRNA levels fibroblasts adrenal gland. Conversely, GA/GG reduced nucleus accumbens frontal cortex. Our results demonstrate are among women.
Language: Английский
Citations
0
Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 15, 2025
Postoperative cognitive dysfunction (POCD) is a common complication after total knee arthroplasty (TKA), impacting recovery and quality of life. This study aims to investigate central sensitization (CS) as an independent risk factor for POCD improve preoperative screening postoperative interventions. A retrospective analysis was conducted on 142 TKA patients from January 2020 May 2024 across three hospitals. Data were collected at six time points: preoperatively (T0), intraoperatively (T1), postoperatively days 1 (T2), 3 (T3), 7 (T4), 30 (T5). Patients classified into CS (CSI ≥ 40) non-CS < groups according Central Sensitization Inventory (CSI) score. Cognitive function incidence assessed with the Mini-Mental State Examination (MMSE), Knee Injury Osteoarthritis Outcome Score (KOOS). Logistic regression used identified factors POCD. The overall T5 19.72%, significantly higher rate in group (30.91%) compared (12.64%) (p = 0.008). MMSE scores declined both T2 T3 T0 0.05), showing consistently lower than T2-T5 0.05). KOOS revealed that had worse pain life T0, T4, CS, cerebrovascular disease, intraoperative hemorrhage, associated significant following TKA, adversely affecting terms Prospective studies are warranted validate findings develop targeted
Language: Английский
Citations
0
International Journal of Developmental Neuroscience, Journal Year: 2025, Volume and Issue: 85(1)
Published: Feb. 1, 2025
Contact between mother and child is essential for the proper development of an infant's physiological systems, brain maturation behavioural outcomes. Early life stress (ELS), which includes factors such as inadequate parental care childhood abuse, significantly increases risk developing neuropsychiatric disorders, including anxiety depression. This review examines impact maternal separation (MS) on depression, pain behaviour, with a particular emphasis neuroinflammatory pathways. Experiences ELS can adversely affect neurotransmitter systems associated neural circuits that are crucial processing painful stimuli regulating Stressful experiences trigger inflammatory processes in brain, initiating immune responses cells stimulating production pro-inflammatory cytokines. In mammals, MS serves significant stressor activates hypothalamic-pituitary-adrenal (HPA) axis other stress-related leading to increased challenges heightened sensitivity adulthood due systemic inflammation. Key mediators, IL-1β, IL-6 TNF-α, play critical roles pathological pain, while activation microglia releases mediators contribute neurological dysfunction pathophysiology stress, depression anxiety. Moreover, therapeutics targeting oxidative inflammation have shown promise alleviating affective disorders following MS. discusses potential pathways, primary focus mechanisms therapeutic strategies may mitigate adverse effects There pressing need further research elucidate underlying pathways identify effective interventions improve mental health outcomes individuals affected by
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1770 - 1770
Published: Feb. 19, 2025
Endometriosis is a complicated, estrogen-dependent gynecological condition with high morbidity rate. Pain, as the most common clinical symptom of endometriosis, severely affects women's physical and mental health exacerbates socioeconomic burden. However, specific mechanisms behind occurrence endometriosis-related pain remain unclear. It currently believed that endometriosis related to various factors, such immune abnormalities, endocrine disorders, brain-gut axis, angiogenesis, mechanical stimulation. These factors induce systemic chronic inflammation, which stimulates nerves subsequently alters neural plasticity, leading nociceptive sensitization thereby causing pain. In this paper, we compile review articles published on study mechanisms. Starting from influencing associated explain relationship between these inflammation further elaborate potential by induces sensitization. We aim reveal possible pain, well sensitization, offer new targets for treatment
Language: Английский
Citations
0
The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(9)
Published: May 7, 2025
ABSTRACT Fatty acid binding protein 7 (FABP7) is prominently expressed in astrocytes and a critical regulator of inflammatory responses. Accumulating evidence suggests that FABP7 crucial neuropsychological disease through the modulation spinogenesis. Nonetheless, impact on depressive disorders underlying mechanisms not fully understood. Here, we investigated antidepressant properties using chronic unpredictable mild stress (CUMS)‐induced model depression possible mechanisms. Our results revealed depressive‐like behavior induced by CUMS was associated with decreased levels hippocampus (HP). Furthermore, overexpression HP mitigated increased expression its downstream target caveolin‐1 (Cav‐1). specifically regulates astrocyte marker GFAP, as well blood–brain barrier (BBB)‐associated proteins AQP4, CLDN‐5, occludin, LRP1. Notably, CUMS‐induced upregulation pro‐inflammatory factors IL‐1β IL‐6 also significantly reversed HP. This intervention led to postsynaptic proteins, including PSD95 GluA1, an increase brain‐derived neurotrophic factor (BDNF) enhanced neuronal dendritic spine density. The findings indicate exerts antidepressant‐like inhibiting inflammation, regulating spinogenesis, modulating BBB‐related proteins.
Language: Английский
Citations
0
Biomaterials, Journal Year: 2024, Volume and Issue: 316, P. 123012 - 123012
Published: Dec. 15, 2024
Language: Английский
Citations
3
Rejuvenation Research, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 27, 2024
Parkinson's disease (PD) is accompanied by a complex array of nonmotor and motor manifestations. The exploration anti-inflammatory antioxidant active ingredient as potential therapeutic interventions in PD-associated mood alterations has gained significant attention. This study aimed to assess the antidepressant anxiolytic properties luteolin (LTN), potent component, using 6-hydroxydopamine (6-OHDA)-induced animal model PD. Rats were administered LTN (10, 25, 50 mg/kg, per oral) fluoxetine (10 mg/kg/per over 28-day period. Behavioral tests employed estimate depression- anxiety-like behaviors. treated with exhibited improvement 6-OHDA-induced alterations, behavioral tests. Additionally, treatment led increased hippocampal levels catalase superoxide dismutase, reduction malondialdehyde. downregulated gene expression nuclear factor kappa B (NF-κB)/nod-like receptor (NLR) pyrin domain-containing 3 (NLRP3) axis components, including NF-κB, NLRP3, ASC, Caspase1 reduced protein level pro-inflammatory cytokines, interleukin (IL)-6, (IL)-1β, tumor necrosis alpha (TNF-α), addition augmenting TNF-α, IL-1β, IL-6. Furthermore, an upregulatory effect on cytokine IL-10 within hippocampus PD rats. Also, molecular docking showed higher affinity between NF-κB/NLRP3 components. These findings highlight impacts through its mechanisms against rat model.
Language: Английский
Citations
2
Expert Opinion on Pharmacotherapy, Journal Year: 2024, Volume and Issue: 25(17), P. 2267 - 2282
Published: Nov. 14, 2024
Endometriosis affects 5% to 10% of reproductive age women and may be associated with severely painful debilitating symptoms as well infertility. involves hormonal fluctuations, angiogenesis, neurogenesis, vascular changes neuroinflammatory processes. The component endometriosis makes it a systemic disorder, similar other chronic epithelial inflammatory conditions.
Language: Английский
Citations
1