Iron-Dependent Cell Death: Exploring Ferroptosis as a Unique Target in Triple-Negative Breast Cancer Management

Cancer Management and Research, Journal Year: 2025, Volume and Issue: Volume 17, P. 625 - 637

Published: March 1, 2025

Triple-negative breast cancer (TNBC) is characterized by aggressive behavior, high metastatic potential, and frequent relapses, presenting significant treatment challenges. Ferroptosis, a unique form of programmed cell death marked iron-dependent lipid peroxidation, has emerged as crucial factor in biology. Recent studies indicate that TNBC cells possess distinct metabolic profile linked to iron glutathione, which may render them more susceptible ferroptosis than other subtypes. Moreover, plays role the interactions between immune tumor cells, suggesting its potential modulate microenvironment influence response against TNBC.Evidence reveals not only affects viability but also alters promoting release damage-associated molecular patterns (DAMPs), can recruit site. Specific ferroptosis-related genes biomarkers, such ACSL4 GPX4, demonstrate altered expression tissues, offering promising avenues for diagnostic prognostic applications. Furthermore, preclinical models, induction been shown enhance efficacy existing therapies, indicating synergistic effect could be harnessed therapeutic benefit. The compelling link underscores novel target. Future research should focus on developing strategies exploit conjunction with traditional including identification natural compounds efficacious inducers personalized regimens. This review elucidates multifaceted implications TNBC, providing valuable insights improving both diagnosis this formidable subtype.

Language: Английский

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Synergistic strength: unleashing exercise and polyphenols against breast cancer

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 15, 2025

Breast cancer remains a major global health challenge, necessitating innovative preventive and therapeutic strategies. Emerging evidence such as clinical trials suggests that the combination of exercise polyphenol intake exerts synergistic effects in mitigating breast progression by modulating key molecular pathways. Exercise enhances immune function, reduces inflammation, regulates cellular metabolism, while polyphenols, natural compounds found various plant-based foods, exhibit antioxidant, anti-inflammatory, anti-carcinogenic properties. Together, these interventions influence apoptosis, oxidative stress, ferroptosis which play crucial roles pathophysiology. This review explores mechanisms underlying combined impact polyphenols on prevention treatment. Understanding interplay between at level could pave way for novel, non-invasive Future research should focus optimizing regimens dietary to maximize their anti-cancer benefits. By bridging insights with applications, this aims provide foundation incorporating lifestyle-based into management. Our findings collectively highlight promising potential combining curcumin supplementation multifaceted approach The observed studies suggest integrating lifestyle modifications may enhance efficacy mitigate progression. Further investigations are warranted validate results explore applicability human subjects. supports holistic strategy management improve patient outcomes quality life during

Language: Английский

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The inhibitory effects of modified HSJZ decoction on NSCLC by regulating regulatory T cells via downregulation of EZH2 and PI3K/AKT pathway

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119802 - 119802

Published: April 1, 2025

Language: Английский

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Astragalus membranaceus: A Traditional Chinese Medicine with Multifaceted Impacts on Breast Cancer Treatment

Biomolecules, Journal Year: 2024, Volume and Issue: 14(10), P. 1339 - 1339

Published: Oct. 21, 2024

Breast cancer, the most prevalent malignant tumor among women globally, remains a critical area of focus for researchers striving to refine therapeutic approaches. As an important component traditional Chinese medicine,

Language: Английский

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Ononin Inhibits Tumor Bone Metastasis and Osteoclastogenesis Via Targeting MAPK Pathway in Breast Cancer

Research, Journal Year: 2024, Volume and Issue: 7

Published: Jan. 1, 2024

Breast cancer (BC) often spreads to bones, leading bone metastasis (BM). Current targeted therapies have limited effectiveness in the treatment of this condition. Osteoclasts, which contribute destruction, are crucial supporting tumor cell growth bones. (BCBM) treatments efficacy and can cause adverse effects. Ononin exhibits anticancer properties against various cancers. The study examined impact ononin on BCBM signaling pathways involved. Our utilized a variety experimental techniques, including viability assays, colony formation wound-healing Transwell migration Western blot analysis, tartrate-resistant acid phosphatase (TRAP) staining. We effects osteoclastogenesis induced MDA-MB-231 conditioned medium- RANKL-treated RAW 264.7 cells. In mouse model BCBM, reduced tumor-induced destruction. effectively inhibited proliferation metastatic capabilities cells by suppressing adhesion, invasiveness, motility reversing epithelial–mesenchymal transition (EMT) markers. markedly suppressed osteoclast osteolysis-associated factors cells, as well blocked activation mitogen-activated protein kinase (MAPK) pathway down-regulated phosphorylation MAPK pathways, confirmed using agonists or inhibitors. had no organ function. findings suggest that has therapeutic potential targeting pathway.

Language: Английский

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Metabolomics reveal changes of flavonoids during processing of "nine-processed" tangerine peel (Jiuzhi Chenpi)

LWT, Journal Year: 2024, Volume and Issue: unknown, P. 117132 - 117132

Published: Nov. 1, 2024

Language: Английский

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Targeting PI3K/AKT/mTOR Signalling pathway in non-small-cell lung carcinoma: Exploring promising bioactive natural compounds as anti-cancer agents

Chemical Physics Impact, Journal Year: 2024, Volume and Issue: unknown, P. 100793 - 100793

Published: Nov. 1, 2024

Language: Английский

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