Nature’s Arsenal: Harnessing the Capacity of Phytochemicals to Enhance Immune Checkpoint Inhibitor Therapy of Cancers: An Especial Attention to Brain Malignancies

Cancer Letters, Journal Year: 2024, Volume and Issue: 593, P. 216955 - 216955

Published: May 14, 2024

Language: Английский

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Absence of Astrocytic Ceruloplasmin Reverses the Senescence Process with Aging of Learning and Memory Abilities

Redox Biology, Journal Year: 2025, Volume and Issue: unknown, P. 103611 - 103611

Published: March 1, 2025

Ceruloplasmin (CP) is a multi-copper ferroxidase mainly synthesized by liver, secreted into the peripheral blood, playing critical role in regulating iron homeostasis. In central nervous system (CNS), CP expressed astrocytes plays an important transportation of from blood across blood-brain barrier (BBB) brain. Our previous study showed that conditional knockout astrocytic with Cre-LoxP (CpGfapcKO) not only improved learning and memory abilities elderly mice, but also impaired young mice. order to further investigate effects on aging, we constructed mice model tamoxifen-induced astrocyte specific CP, induced at 12 months old, observed mouse 18 old. We were delighted found ablation tamoxifen old could similarly enhance learning, recognition 18-month-old Iron deposition hippocampus associated aging was mitigated, leading reduction oxidative stress. The MAPK/JNK pathway exhibited attenuation, while PI3K/Akt/GSK3 enhancement. This combination expected result phosphorylation level MYC elevation nuclear translocation MYC, which might then contribute reduced cellular senescence. Additionally, ROS/MAPK/Erk ROS/MAPK/p38 pathways-dependent cell apoptosis diminished. hallmarks Alzheimer's Disease (AD) all significantly reduced. Ultimately, alleviated senescence along AD-related markers, coincided improvement memory, abilities. These findings elucidated brain metabolism, offering novel target strategy for prevention treatment neurodegenerative diseases, such as AD aging.

Language: Английский

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Plant Polyphenol‐Based Injectable Hydrogels: Advances and Biomedical Applications

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Plant polyphenol-based hydrogels, known for their biocompatibility and adhesive properties, have emerged as promising materials in biomedical applications. These hydrogels leverage the catechol group's ability to form stable bonds moist environments, similar mussel proteins. This review provides a comprehensive overview of synthesis, adhesion mechanisms, applications, particularly wound healing, tissue regeneration, drug delivery. However, challenges related vivo stability long-term remain critical barriers clinical translation. Future research should focus on enhancing bioactivity, biocompatibility, scalability these while addressing concerns toxicity, immune responses, large-scale manufacturing. Advances artificial intelligence-assisted screening 3D/4D bioprinting are expected accelerate development Furthermore, integration biomimetic designs responsive functionalities, such pH or temperature sensitivity, holds promise further improving therapeutic efficacy. In conclusion, multifunctional plant represents frontier advancing personalized medicine minimally invasive treatments.

Language: Английский

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THE REGULATORY EFFECTS OF EPIGALLOCATECHIN GALLATE ON GROWTH PERFORMANCE, SYSTEMIC ANTIOXIDANT STATUS, IMMUNE RESPONSE, AND GUT MICROBIOTA STRUCTURE IN GEESE

Poultry Science, Journal Year: 2025, Volume and Issue: 104(7), P. 105178 - 105178

Published: April 16, 2025

Language: Английский

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New benzophenone analogs from Nigrospora sphaerica and their inhibitory activity against PD-1/PD-L1 interactions

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 153, P. 107899 - 107899

Published: Oct. 19, 2024

Language: Английский

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