Natural Products in the Prevention of Degenerative Bone and Joint Diseases: Mechanisms Based on the Regulation of Ferroptosis DOI Open Access

Kuanhui Gao,

Lizhi Lv, Zhichao Li

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Degenerative bone and joint diseases (DBJDs), characterized by osteoporosis, osteoarthritis, chronic inflammation of surrounding soft tissues, are systemic conditions primarily affecting the skeletal system. Ferroptosis, a programmed cell death pathway distinct from apoptosis, autophagy, necroptosis. Accumulating evidence suggests that ferroptosis is intricately linked to pathogenesis DBJDs, targeting its regulation could be beneficial in managing these conditions. Natural products, known for their anti-inflammatory antioxidant properties, have shown unique advantages preventing potentially through modulating ferroptosis. This article provides an overview latest research on ferroptosis, with focus role DBJDs therapeutic potential natural products this pathway, offering novel insights prevention treatment DBJDs.

Language: Английский

LGR4 (GPR48): The Emerging Inter-Bridge in Osteoimmunology DOI Creative Commons
Wonbong Lim

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 607 - 607

Published: March 2, 2025

Leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4), a member of the (GPCR) family, has been implicated in various regulatory functions across multiple differentiation stages and numerous target sites bone diseases. Therefore, LGR4 is potential regulator nuclear factor-κB ligand (RANKL) during osteoclast differentiation. However, comprehensive investigation its applications immunology lacking. This review discusses molecular characteristics, signaling pathways, role osteoimmunology, with particular focus on interactions RANKL differentiation, while identifying gaps that warrant further research.

Language: Английский

Citations

0
DPHB inhibits osteoclastogenesis by suppressing NF-κB and MAPK signaling and alleviates inflammatory bone destruction DOI
Caixia Liu,

Min Zuo,

Jing Zhao

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 152, P. 114377 - 114377

Published: March 4, 2025

Language: Английский

Citations

0
Association between leukocyte-based inflammatory indices and bone mineral density in hemodialysis patients DOI Open Access
Javid Mohammadzadeh Azarabadi,

Neveen Shalalfa

Journal of Medicine and Palliative Care, Journal Year: 2025, Volume and Issue: 6(2), P. 131 - 137

Published: March 23, 2025

Aims: Osteoporosis and osteopenia are common among hemodialysis (HD) patients, yet current methods for risk stratification remain limited. This study aimed to investigate the relationship between leukocyte-based inflammatory indices osteoporosis in HD patients assess their diagnostic performance differentiating these conditions. Methods: A retrospective analysis was conducted on 168 classified into normal bone mineral density (BMD) (n=43), (n=70), (n=55) based T-scores by dual-energy X-ray absorptiometry measurements. The were calculated as follows: Platelet lymphocyte ratio (PLR)=platelet count/ count ratio; neutrophil o (NLR)=neutrophil systemic immune inflammation index (SII)=platelet count×neutrophil / ratio, response (SIRI)=neutrophil count×monocyte ratio. Results: Osteopenia identified 41.7% 32.7% of respectively. Patients with exhibited higher monocyte counts lower (p

Language: Английский

Citations

0
Development of a peri-implantitis model in New Zealand white rabbits: A preclinical study DOI
Jian Sun, Yang Sun, Liang Song

et al.

Journal of Prosthetic Dentistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Bone-protective effects of neutralizing angiopoietin-like protein 4 monoclonal antibody in rheumatoid arthritis DOI

Liqing Ke,

Qifei He,

Jing Qu

et al.

Molecular Therapy, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

2
Advanced Bioresponsive Drug Delivery Systems for Promoting Diabetic Vascularized Bone Regeneration DOI
Xiaojun Zhou, Shuo Chen, Andrij Pich

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 11(1), P. 182 - 207

Published: Dec. 12, 2024

The treatment of bone defects in diabetes mellitus (DM) patients remains a major challenge since the diabetic microenvironments significantly impede regeneration. Many abnormal factors including hyperglycemia, elevated oxidative stress, increased inflammation, imbalanced osteoimmune, and impaired vascular system microenvironment will result high rate impaired, delayed, or even nonhealing events tissue. Stimuli-responsive biomaterials that can respond to endogenous biochemical signals have emerged as effective therapeutic systems treat via combination microenvironmental regulation enhanced osteogenic capacity. Following natural healing processes, coupling angiogenesis osteogenesis by advanced bioresponsive drug delivery has proved be significant approach for promoting repair DM. In this Review, we systematically summarized mechanisms strategies DM-induced healing, outlined design systems, highlighted vascularization Accordingly, then overview recent advances developing facilitate vascularized regeneration remodeling modulating multiple regenerative cues. Furthermore, discuss development adaptable with unique features guiding DM-associated future.

Language: Английский

Citations

1
Natural Products in the Prevention of Degenerative Bone and Joint Diseases: Mechanisms Based on the Regulation of Ferroptosis DOI Open Access

Kuanhui Gao,

Lizhi Lv, Zhichao Li

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Degenerative bone and joint diseases (DBJDs), characterized by osteoporosis, osteoarthritis, chronic inflammation of surrounding soft tissues, are systemic conditions primarily affecting the skeletal system. Ferroptosis, a programmed cell death pathway distinct from apoptosis, autophagy, necroptosis. Accumulating evidence suggests that ferroptosis is intricately linked to pathogenesis DBJDs, targeting its regulation could be beneficial in managing these conditions. Natural products, known for their anti-inflammatory antioxidant properties, have shown unique advantages preventing potentially through modulating ferroptosis. This article provides an overview latest research on ferroptosis, with focus role DBJDs therapeutic potential natural products this pathway, offering novel insights prevention treatment DBJDs.

Language: Английский

Citations

0