The association between vitamin D receptor gene polymorphism FokI and type 2 diabetic kidney disease and its molecular mechanism: a case control study DOI Creative Commons

Yaping Zhao,

Zehui Liu, Shiyu Feng

et al.

BMC Medical Genomics, Journal Year: 2024, Volume and Issue: 17(1)

Published: Dec. 18, 2024

Language: Английский

Ferroptosis: a novel mechanism of cell death in ophthalmic conditions DOI Creative Commons
Yaqi Yang,

Yumeng Lin,

Zhongyu Han

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 27, 2024

Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation differs from death, such as apoptosis, necrosis, autophagy. Ferroptosis associated with variety physiological pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence development diseases targeting metabolic pathways signaling tumors, ischemic organ damage, other degenerative related to peroxidation. Increasing evidence suggests closely linked onset progression various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, retinoblastoma. Our review current research on reveals significant advancements our understanding pathogenesis, aetiology, treatment these conditions.

Language: Английский

Citations

5
HO-1-Mediated Ferroptosis Regulates Retinal Neovascularization via the COX2/VEGFA Axis DOI
Haixiang Zhou, Bingyan Li,

Zicong Wang

et al.

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 226, P. 84 - 95

Published: Nov. 12, 2024

Language: Английский

Citations

2
Multi-omics in exploring the pathophysiology of diabetic retinopathy DOI Creative Commons
Xinlu Li, Xifeng Dong, Wen Zhang

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 11, 2024

Diabetic retinopathy (DR) is a leading global cause of vision impairment, with its prevalence increasing alongside the rising rates diabetes mellitus (DM). Despite retina's complex structure, underlying pathology DR remains incompletely understood. Single-cell RNA sequencing (scRNA-seq) and recent advancements in multi-omics analyses have revolutionized molecular profiling, enabling high-throughput analysis comprehensive characterization biological systems. This review highlights significant contributions scRNA-seq, conjunction other technologies, to research. Integrated scRNA-seq transcriptomic revealed novel insights into pathogenesis, including alternative transcription start site events, fluctuations cell populations, altered gene expression profiles, critical signaling pathways within retinal cells. Furthermore, by integrating genetic association studies analyses, researchers identified biomarkers, susceptibility genes, potential therapeutic targets for DR, emphasizing importance specific types disease progression. The integration metabolomics has also been instrumental identifying metabolites dysregulated associated DR. It highly conceivable that continued synergy between approaches will accelerate discovery mechanisms development interventions

Language: Английский

Citations

0
The association between vitamin D receptor gene polymorphism FokI and type 2 diabetic kidney disease and its molecular mechanism: a case control study DOI Creative Commons

Yaping Zhao,

Zehui Liu, Shiyu Feng

et al.

BMC Medical Genomics, Journal Year: 2024, Volume and Issue: 17(1)

Published: Dec. 18, 2024

Language: Английский

Citations

0