Bioactive Compounds from Propolis on Bone Homeostasis: A Narrative Review

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 81 - 81

Published: Jan. 12, 2025

This narrative review explores the potential effects of Propolis and its bioactive compounds on bone health. Propolis, a resinous product collected by bees, is renowned for antimicrobial, anti-inflammatory, antioxidant properties. Recent research emphasizes positive role in osteogenesis, primarily through modulation osteoclast osteoblast activity via molecular pathways. Key mechanisms include reducing inflammatory cytokines, protecting against oxidative stress, upregulating growth factor essential formation. While such as Caffeic Acid Phenethyl Ester, Apigenin, Quercetin, Ferulic have been well-documented, emerging evidence points to significant roles less-studied like Pinocembrin, Kaempferol, p-Coumaric acid, Galangin. synthesizes current literature, focusing which these influence osteogenesis. Firstly, it techniques characterizing presented propolis, chemogeographic variations composition, both crude extracts isolated tissue, offering comprehensive analysis recent findings across different experimental models. Further, discusses In summary, modulate signaling pathways, including nuclear kappa beta, wingless-related integration site, mitogen-activated protein kinase, vascular endothelial factor, reactive oxygen species. These pathways receptor activator kappa-β/receptor kappa-β ligand/osteoprotegerin system, fostering cell differentiation. regulation mitigates excessive formation, stimulates activity, ultimately contributes restoration homeostasis maintaining balanced remodeling process.

Language: Английский

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Tannic Acid Mitigates Salmonella-Induced Lung Injury via Gut-lung Axis in Broilers

Poultry Science, Journal Year: 2025, Volume and Issue: 104(4), P. 104973 - 104973

Published: March 3, 2025

Tannic acid (TA), a polyphenolic compound derived from plants, exhibits anti-inflammatory, antibacterial, antiviral, and antioxidant biological activities. Salmonella, prevalent foodborne pathogen, poses significant threat to poultry, resulting in considerable economic losses for the animal husbandry industry. In this study, we investigated protective effects of TA against lung intestinal injuries induced by transient Salmonella infection broilers. After ten-day period, although was not detected content broilers, infected broilers exhibited reduced body weight compromised barrier function. facilitated growth detrimental bacteria lungs ileums, triggering an inflammatory response. inhibited pathogen's colonization serum levels lipopolysaccharide (LPS) as well myeloperoxidase (MPO). Moreover, down-regulated expression pro-inflammatory cytokines hindered polarization M1 macrophages lungs. summary, mitigates Salmonella-induced inflammation immune imbalance its antibacterial properties

Language: Английский

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Flammulina velutipes residue Polysaccharide Alleviates Immunosuppression and Intestinal Injury by Modulating Gut Microbiota and Associated Metabolites

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

This study elucidated the mechanisms underlying immunoregulatory and gut-microbiota-modulating effects of Flammulina velutipes residue polysaccharide (FVRP) using cyclophosphamide (CTX)-induced mouse models. FVRP supplementation alleviated CTX-induced intestinal damage boosted antioxidant enzyme activity cytokine secretion. Additionally, enhanced diversity total species richness gut microbiota, promoting proliferation beneficial bacteria (e.g., Prevotellaceae), while reducing abundance CTX-derived (Lachnospiraceae Rikenellaceae). facilitates accumulation short-chain fatty acids. Untargeted metabolomic analyses cecal content revealed that treatment notably restored levels 32 endogenous metabolites altered by CTX. Based on a pseudosterility mice model, fecal microbiota transplantation (FMT), filtrate (FFT), associated were demonstrated to play crucial role in immunomodulatory protective against injury. In conclusion, exhibits significant potential as an immune enhancer natural therapeutic agent for alleviating inflammatory conditions.

Language: Английский

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Therapeutic effects of quercetin supplementation on oral and gut microbiota in Autism Spectrum Disorder (ASD)

Cuadernos de Educación y Desarrollo, Journal Year: 2025, Volume and Issue: 17(4), P. e7926 - e7926

Published: April 4, 2025

Due to the characterization of Autism Spectrum Disorder (ASD) as a multifaceted syndrome, most diagnoses are still not precise. To avoid pharmacological treatments, natural strategies with significant potential reduce oxidative stress sought. This study aims identify influence quercetin on oral and gut microbiota, well evaluate action this bioactive compound in relation signs symptoms that characterize ASD individuals. research, is systematic review, was conducted PubMed platform from 2014 2024. The keywords used were: “quercetin autismo”; “autism, antioxidante”; microbiota”; intestinal microbiota.” Evidences showed reduces under various conditions, both vitro vivo, indicated mitochondrial function optimization protection against xenobiotic-induced damage. It demonstrated benefits such improved cognitive function, reduced blood glucose levels, activation SIRT1 enzyme. preserved microbial diversity dominance inflammatory taxonomic groups. positively influenced microbiota by decreasing Firmicutes increasing Bacteroidetes. could represent novel approach conditions related gut-brain-microbiota axis. Studies suggest offers promising mitigate physiological manifestation challenges, improve responses, act potent antioxidant, modulate microbiota. hoped attention these individuals will continue grow progressively.

Language: Английский

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Sildenafil promotes osteogenic differentiation of human mesenchymal stem cells and inhibits bone loss by affecting the TGF-β signaling pathway

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 23, 2025

Osteoporosis, a common bone disorder, is primarily managed pharmacologically. However, existing medications are associated with non-trivial side-effects. Sildenafil, which already finds many clinical applications, promotes angiogenesis and cellular differentiation. Osteoporotic patients often exhibit reduced intraosseous vasculature impaired differentiation; sildenafil may thus usefully treat osteoporosis. Here, the effects of on osteogenic differentiation human mesenchymal stem cells (hMSCs) were explored, as molecular mechanisms in play. We treated hMSCs varying concentrations measured cell proliferation vitro. used mouse model subcutaneous ectopic osteogenesis to assess sildenafil's effect hMSC vivo. also explored loss tail-suspended (TS) ovariectomized (OVX) mice. Mechanistically, we employed RNA-sequencing define potentially relevant pathways. The appropriate significantly enhanced optimal concentration be 10 mg/L. Sildenafil mitigated osteoporosis OVX TS probably promoted by acting transforming growth factor-β (TGF-β) signaling pathway. In conclusion, inhibited loss. Our findings offer new insights into physiological medicine.

Language: Английский

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Dietary Fiber Intake Improves Osteoporosis Caused by Chronic Lead Exposure by Restoring the Gut–Bone Axis

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1513 - 1513

Published: April 29, 2025

Background: Lead (Pb), a pervasive environmental toxicant with specific toxicity to bone, has been recognized as significant etiological factor in the pathogenesis of osteoporosis. While dietary fiber (DF) demonstrates anti-osteoporotic potential, its protective role against Pb-induced bone loss remains unexplored. Methods: This study analyzed association between fiber, blood lead, and osteoporosis based on NHANES database, validated it by constructing lead exposed mouse model. Micro CT was used evaluate microstructure, ELISA detect markers, q-PCR/Western blot measure intestinal tight junction protein, flow cytometry analyze Treg cells colon/bone tissue, GC-MS short chain fatty acids, 16S rRNA sequencing changes gut microbiota. The regulatory mechanism metabolism barrier mice systematically evaluated. Results: Based data analysis, found that can reduce risk populations. Animal experiments have shown intervention significantly increases density, improves microstructure metabolic indicators, repairs damage caused exposure, regulates immune balance mice. At same time, promotes generation acids proliferation beneficial Conclusions: These findings indicate DF mitigates through restoration, SCFA-mediated immunomodulation, microbiota-driven cell expansion along gut–bone axis.

Language: Английский

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Investigating the mechanism of enhanced medicinal effects of Terminalia chebula fruit after processing based on intestinal flora and metabolomics

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113271 - 113271

Published: Oct. 4, 2024

Language: Английский

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Polysaccharides from Yupingfeng granules ameliorated cyclophosphamide-induced immune injury by protecting intestinal barrier

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 146, P. 113866 - 113866

Published: Dec. 21, 2024

Language: Английский

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