The Role of Mitochondrial Solute Carriers SLC25 in Cancer Metabolic Reprogramming: Current Insights and Future Perspectives DOI Open Access
Amer Ahmed, Giorgia Natalia Iaconisi, Daria Di Molfetta

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 92 - 92

Published: Dec. 26, 2024

Cancer cells undergo remarkable metabolic changes to meet their high energetic and biosynthetic demands. The Warburg effect is the most well-characterized alteration, driving cancer catabolize glucose through aerobic glycolysis promote proliferation. Another prominent hallmark of increased reliance on glutamine replenish tricarboxylic acid (TCA) cycle intermediates essential for ATP production, aspartate fatty synthesis, maintaining redox homeostasis. In this context, mitochondria, which are primarily used maintain energy homeostasis support balanced biosynthesis in normal cells, become central organelles fulfilling heightened demands proliferating cells. Mitochondrial coordination metabolite exchange with other cellular compartments crucial. human SLC25 mitochondrial carrier family, comprising 53 members, plays a pivotal role transporting TCA intermediates, amino acids, vitamins, nucleotides, cofactors across inner membrane, thereby facilitating cross-talk. Numerous studies have demonstrated that carriers altered actively contributing tumorigenesis. This review comprehensively discusses pathogenesis reprogramming based current experimental evidence. It also highlights research gaps need be addressed future studies. Understanding involvement these tumorigenesis may provide valuable novel targets drug development.

Language: Английский

A Novel Ferroptosis-Related Gene Prognosis Signature and Identifying Atorvastatin as a Potential Therapeutic Agent for Hepatocellular Carcinoma DOI Creative Commons

Ling Wang,

Xiaoqin He, Yang Shen

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(3), P. 201 - 201

Published: March 18, 2025

Among the most common malignant tumors, hepatocellular carcinoma (HCC) is a primary liver cancer type that has high mortality rate. HCC often presents insidiously, prone to recurrence, and limited treatment efficacy. Ferroptosis regulates tumorigenesis, progression, metastasis, which novel form of iron-dependent cell death. Numerous studies suggest sensitive ferroptosis, indicating targeted therapies aimed at inducing ferroptosis may represent promising new approach treatment. This study aims find genes associated with as well screen for potential agents cause in HCC. Transcriptome clinical sample data were obtained from TCGA database identify differentially expressed related ferroptosis. Using various regression survival analysis techniques, we developed prognostic model based on four core evaluated its predictive potential. Subsequently, screened therapeutic Connective Map (CMap) database, designated compound Atorvastatin, differential two risk groups Through experiments conducted vivo vitro, demonstrated Atorvastatin can induce cells while inhibiting their growth migration. In conclusion, this research targets therapy provides insights improving prediction prevention

Language: Английский

Citations

2
Recent Advances on the Role of B Vitamins in Cancer Prevention and Progression DOI Open Access

Zachary Frost,

Sandra Bakhit,

Chelsea N. Amaefuna

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1967 - 1967

Published: Feb. 25, 2025

Water-soluble B vitamins, mainly obtained through dietary intake of fruits, vegetables, grains, and dairy products, act as co-factors in various biochemical processes, including DNA synthesis, repair, methylation, energy metabolism. These vitamins include B1 (Thiamine), B2 (Riboflavin), B3 (Niacin), B5 (Pantothenic Acid), B6 (Pyridoxine), B7 (Biotin), B9 (Folate), B12 (Cobalamin). Recent studies have shown that besides their fundamental physiological roles, influence oncogenic metabolic pathways, glycolysis (Warburg effect), mitochondrial function, nucleotide biosynthesis. Although deficiencies these are associated with several complications, emerging evidence suggests excessive specific may also contribute to cancer progression interfere therapy due impaired genetic functions. This review discusses the tumor-suppressive tumor-progressive roles cancer. It explores recent on a comprehensive understanding relationship between vitamin metabolism underscores need for further research determine optimal balance prevention therapy.

Language: Английский

Citations

0
MCM4 potentiates evasion of hepatocellular carcinoma from sorafenib-induced ferroptosis through Nrf2 signaling pathway DOI

Xujin Liu,

Fan Zhang, Yu‐Chen Fan

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113107 - 113107

Published: Sept. 13, 2024

Language: Английский

Citations

3
The Role of Mitochondrial Solute Carriers SLC25 in Cancer Metabolic Reprogramming: Current Insights and Future Perspectives DOI Open Access
Amer Ahmed, Giorgia Natalia Iaconisi, Daria Di Molfetta

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 92 - 92

Published: Dec. 26, 2024

Cancer cells undergo remarkable metabolic changes to meet their high energetic and biosynthetic demands. The Warburg effect is the most well-characterized alteration, driving cancer catabolize glucose through aerobic glycolysis promote proliferation. Another prominent hallmark of increased reliance on glutamine replenish tricarboxylic acid (TCA) cycle intermediates essential for ATP production, aspartate fatty synthesis, maintaining redox homeostasis. In this context, mitochondria, which are primarily used maintain energy homeostasis support balanced biosynthesis in normal cells, become central organelles fulfilling heightened demands proliferating cells. Mitochondrial coordination metabolite exchange with other cellular compartments crucial. human SLC25 mitochondrial carrier family, comprising 53 members, plays a pivotal role transporting TCA intermediates, amino acids, vitamins, nucleotides, cofactors across inner membrane, thereby facilitating cross-talk. Numerous studies have demonstrated that carriers altered actively contributing tumorigenesis. This review comprehensively discusses pathogenesis reprogramming based current experimental evidence. It also highlights research gaps need be addressed future studies. Understanding involvement these tumorigenesis may provide valuable novel targets drug development.

Language: Английский

Citations

0