Unveiling ferroptosis: a new frontier in skin disease research DOI Creative Commons
Ke Wang,

Yumeng Lin,

Dan Zhou

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 4, 2024

Ferroptosis, a form of regulated cell death distinct from apoptosis, necrosis, and autophagy, is increasingly recognized for its role in skin disease pathology. Characterized by iron accumulation lipid peroxidation, ferroptosis has been implicated the progression various conditions, including psoriasis, photosensitive dermatitis, melanoma. This review provides an in-depth analysis molecular mechanisms underlying compares cellular effects with other forms context health disease. We systematically examine five specific diseases, ichthyosis, polymorphous light eruption (PMLE), vitiligo, melanoma, detailing influence on pathogenesis progression. Moreover, we explore current clinical landscape ferroptosis-targeted therapies, discussing their potential managing treating diseases. Our aim to shed therapeutic modulating research practice.

Language: Английский

Lachnospiraceae-bacterium alleviates ischemia-reperfusion injury in steatotic donor liver by inhibiting ferroptosis via the Foxo3-Alox15 signaling pathway DOI Creative Commons
Shenghe Deng, Huan Cao,

Tongxi Li

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 30, 2025

Ischemia-reperfusion injury (IRI) is a major obstacle in liver transplantation, especially with steatotic donor livers. Dysbiosis of the gut microbiota has been implicated modulating IRI, and Lachnospiraceae plays pivotal role regulating host inflammatory immune responses, but its specific transplantation IRI remains unclear. This study explores whether can mitigate underlying mechanisms. We found Lachnospiraceae-bacterium (Lachn.) abundance was significantly reduced rats cirrhosis. Lachn.-treated exhibited improved intestinal permeability, severity both normal livers, decreased levels neutrophil macrophage infiltration, cytokines. Multi-omics analysis revealed elevated pyruvate transplanted livers after Lachn. treatment, alongside Alox15 Foxo3 expression. Mechanistically, Lachn.-derived inhibited expression ferroptosis Furthermore, nuclear translocation further suppressed expression, alleviating Clinical samples confirmed cirrhotic recipients high transplantation. In conclusion, alleviates by inhibiting via Foxo3-Alox15 axis, providing potential therapeutic strategy to modulate alleviate following

Language: Английский

Citations

2
From mechanisms to medicine: Ferroptosis as a Therapeutic target in liver disorders DOI Creative Commons
Yuqi He,

Yumeng Lin,

Jinfeng Song

et al.

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 7, 2025

In recent 10 years, ferroptosis has become a hot research direction in the scientific community as new way of cell death. Iron toxicity accumulation and lipotoxicity are unique features. Several studies have found that is involved regulation hepatic microenvironment various metabolisms, thereby mediating progression related liver diseases. For example, NRF2 FSP1, important regulatory proteins ferroptosis, development tumors failure. this manuscript, we present mechanisms concern with addition, summarize clinical advances targeted therapy for We expect manuscript can provide perspective treatment

Language: Английский

Citations

0
Exploring mechanisms of skin aging: insights for clinical treatment DOI Creative Commons

Meiqi Zhang,

Yumeng Lin,

Zhongyu Han

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 8, 2024

The skin is the largest organ in human body and made up of various cells structures. Over time, will age, which not only influenced by internal factors, but also external environmental especially ultraviolet radiation. Aging causes immune system weakening elderly, makes them more susceptible to dermatosis, such as type 2 inflammatory mediated pruritus. response this condition marked senescent consistently releasing low amounts pro-inflammatory cytokines through a senescence-associated secretory phenotype (SASP). This continuous inflammation may accelerate aging establish connection between diseases. In addition, two chronic pigmentation disorders, vitiligo chloasma, are associated with aging. Aged escape accumulate tissues, forming microenvironment that promotes cancer. At same "photoaging" caused excessive exposure radiation an important cause manuscript describes possible links inflammation, cancer suggests some treatment options.

Language: Английский

Citations

1
Unveiling ferroptosis: a new frontier in skin disease research DOI Creative Commons
Ke Wang,

Yumeng Lin,

Dan Zhou

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 4, 2024

Ferroptosis, a form of regulated cell death distinct from apoptosis, necrosis, and autophagy, is increasingly recognized for its role in skin disease pathology. Characterized by iron accumulation lipid peroxidation, ferroptosis has been implicated the progression various conditions, including psoriasis, photosensitive dermatitis, melanoma. This review provides an in-depth analysis molecular mechanisms underlying compares cellular effects with other forms context health disease. We systematically examine five specific diseases, ichthyosis, polymorphous light eruption (PMLE), vitiligo, melanoma, detailing influence on pathogenesis progression. Moreover, we explore current clinical landscape ferroptosis-targeted therapies, discussing their potential managing treating diseases. Our aim to shed therapeutic modulating research practice.

Language: Английский

Citations

0