Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2571 - 2571
Published: Nov. 10, 2024
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Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 3, 2025
The crosstalk between immunity and cancer in the regulation of tumor growth is considered a hallmark cancer. Antitumor refers to innate adaptive immune responses that regulate development proliferation. Tumor evasion represents major hindrance effective anticancer treatment. Extracellular vesicles (EVs) are nano-sized lipid-bilayer-enclosed particles secreted extracellular space by all cell types. They critically involved numerous biological functions including intercellular communication. Tumor-derived (TEVs) can transport variety cargo modulate cells microenvironment (TME). This review provides latest update about how evade surveillance exploiting TEVs. First, biogenesis EVs cargo-sorting machinery discussed. Second, differentiation, activation, function via TEVs illustrated. Last but not least, novel antitumor strategies reverse escape summarized.
Language: Английский
Citations
2
Cellular and Molecular Immunology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 9, 2024
Abstract The view of neutrophils has shifted from simple phagocytic cells, whose main function is to kill pathogens, very complex cells that are also involved in immune regulation and tissue repair. These essential for maintaining regaining homeostasis. Neutrophils can be viewed as double-edged swords a range situations. potent killing machinery necessary responses pathogens easily lead collateral damage host tissues when inappropriately controlled. Furthermore, some subtypes pathogen killers, whereas others immunosuppressive or aid healing. Finally, tumor immunology, many examples both protumorigenic antitumorigenic properties have been described. This important consequences cancer therapy, targeting either suppressed stimulated antitumor responses. review will discuss the current knowledge regarding pro- roles neutrophils, leading concept confused state neutrophil-driven pro-/antitumor
Language: Английский
Citations
4
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: April 3, 2025
Language: Английский
Citations
0
Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 4813 - 4830
Published: April 1, 2025
Pancreatic cancer (PCA) is a highly malignant tumor with 5-year survival rate of <10%. It characterized as cold an immunosuppressive microenvironment. Liver dysfunction due to biliary obstruction can affect the inflammation index, indicator immune status. Adjusting indices for liver function may enhance their clinical utility predicting overall (OS) in PCA patients. Resected cases were selected using specific criteria. indicators identified by Spearman's analysis integrated into covariance refine indices, including modified neutrophil-to-lymphocyte ratio (mNLR), platelet-to-lymphocyte (mPLR), lymphocyte-to-monocyte (mLMR), systemic immune-inflammation index (mSII), and C-reactive protein (mCRP). These clinicopathological factors analyzed identify independent OS predictors. A nomogram was developed compared primary inflammation-based model calibration curves, decision curve (DCA), concordance (C-index). direct bilirubin (DBIL), indirect (IBIL), alanine aminotransferase (ALT), aspartate (AST), lactate dehydrogenase (LDH), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), albumin (ALB) indices. In patients, higher mNLR, mSII, CA19-9, T stage, N stage associated worse OS, while mLMR or PNI levels correlated better OS. Vascular invasion predicted poor whereas chemotherapy improved The model's surpassed that model. incorporating demonstrated superior utility. recommended prognostic prediction, especially patients obstruction. For advanced staging poorly differentiated tumors, intraoperative margin nanoknife ablation timely postoperative adjuvant are prognosis.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Sept. 24, 2024
Background Neutrophil extracellular traps (NETs) have long been consistently considered an innate immune defense against foreign pathogens, but this oversimplified view has decelerated the progression of perceiving NET biology in chronic diseases. It is now increasingly accepted that NETs are not exclusive to anti-infection responses, also central players with a double-edged sword role cancer progression. gradually emerged as tumor diagnostic, predictive, and prognostic biomarkers, strenuous endeavors devoted tapping their potential new therapeutic targets. Correspondingly, boom studies on tumors recent years achieved series scientific outputs, which opens up perspective for sophisticated landscapes microenvironment. However, there still much room translate NET-targeted immunotherapies into clinical practice. Therefore, it necessary explore knowledge structure latent hotspots links between using bibliometric analysis. Methods publications from 2006 2024 were extracted Web Science Core Collection. Bibliometric analysis visualization conducted Microsoft Excel, VOSviewer, CiteSpace, R-bibliometrix. Results The included 1,339 authored by 7,747 scholars affiliated 1,926 institutions across 70 countries/regions relevant articles published 538 journals. Despite China’s maximum number publications, United States continued dominate field global cooperation center overwhelming citation counts. Frontiers Immunology most whereas Blood was cited journal. Wagner, Denisa D. Kaplan, Mariana J. concurrently both top 10 prolific authors author lists. Tumor microenvironment immunotherapy will likely be focus future research. Conclusions A comprehensive first map current landscape link hope providing guidance fresh perspectives further research field. promising antitumor targets, perhaps eventual destination realm
Language: Английский
Citations
1
Deleted Journal, Journal Year: 2024, Volume and Issue: 4(2)
Published: May 29, 2024
Background: Chronic inflammation significantly contributes to cancer progression, including colorectal (CRC). Myeloperoxidase (MPO), a key enzyme produced by neutrophils, generates reactive oxygen species (ROS) that lead tissue damage and intensify inflammation. Objectives: This study examines MPO levels in CRC patients compared healthy controls explores the association between elevated other inflammatory markers, lactate dehydrogenase (LDH) erythrocyte sedimentation rate (ESR). Methods: The included 60 participants divided into two groups: Thirty diagnosed with 30 controls, aged 35 75 years. Colorectal were matched for age sex, no significant demographic differences groups. Myeloperoxidase, LDH, ESR measured blood samples using standard biochemical techniques. Statistical analysis was conducted compare groups, chi-square t-tests confirm comparability of characteristics. Results: (P < 0.01), indicating increased neutrophil activity chronic also showed LDH levels, suggesting widespread cellular injury an active response. Furthermore, positively correlated ESR, MPO-driven ROS may contribute systemic Conclusions: results demonstrate are linked damage. identifies as potential biomarker progression suggests targeting MPO-mediated could provide new therapeutic strategies managing CRC. Further research is necessary investigate regulation its target patients.
Language: Английский
Citations
0
Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2571 - 2571
Published: Nov. 10, 2024
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Citations
0