Efficacy of Ergosterol and Ergosterol peroxide in different anti-inflammatory models – a comparison study DOI Creative Commons
Luyao Li, Y. Zhu, Wenjing Cheng

et al.

Food and Agricultural Immunology, Journal Year: 2024, Volume and Issue: 35(1)

Published: Nov. 24, 2024

Ergosterol and its peroxide with important regulatory roles in a variety of intracellular biological processes. In this study, both the LPS- UVA-induced human keratinocyte (HaCaT) inflammatory models were established to investigate anti-inflammatory effects ES EP. The protective EP on UVA LPS-induced cell damage discussed by viability assays, reactive oxygen species levels, skin barrier-related proteins, factors, expression genes involved related signaling pathways analyzed. results showed that could reduce ROS levels; inhibit IL-8 IL-1β secretion; had significant promotion AQP3 FLG, inhibited gene expressions PI3K, AKt, not irritating according safety evaluation. summary, excellent provided degree protection against UVA/LPS-induced damage.

Language: Английский

Oxyberberine Revokes Letrozole-induced Polycystic Ovarian Syndrome and Depression-like Behavior in Female Sprague-Dawley Rats DOI
Manoj P. Dandekar,

Manasi Tadas,

Srilakshmi Satthi

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177613 - 177613

Published: April 1, 2025

Language: Английский

Citations

0
Efficacy of Ergosterol and Ergosterol peroxide in different anti-inflammatory models – a comparison study DOI Creative Commons
Luyao Li, Y. Zhu, Wenjing Cheng

et al.

Food and Agricultural Immunology, Journal Year: 2024, Volume and Issue: 35(1)

Published: Nov. 24, 2024

Ergosterol and its peroxide with important regulatory roles in a variety of intracellular biological processes. In this study, both the LPS- UVA-induced human keratinocyte (HaCaT) inflammatory models were established to investigate anti-inflammatory effects ES EP. The protective EP on UVA LPS-induced cell damage discussed by viability assays, reactive oxygen species levels, skin barrier-related proteins, factors, expression genes involved related signaling pathways analyzed. results showed that could reduce ROS levels; inhibit IL-8 IL-1β secretion; had significant promotion AQP3 FLG, inhibited gene expressions PI3K, AKt, not irritating according safety evaluation. summary, excellent provided degree protection against UVA/LPS-induced damage.

Language: Английский

Citations

1