Study of the relationship between iron metabolism disorders and sepsis-associated liver injury: A prospective observational study DOI
Tianwei Wang, Lulu Zhou, Jing Yuan

et al.

World Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 31(14)

Published: April 9, 2025

Sepsis-associated liver injury (SALI) refers to secondary function impairment caused by sepsis, patients with SALI often have worse clinical outcomes. The early identification and assessment of the occurrence progression are pressing issues that urgently need be resolved. To investigate relationship between iron metabolism SALI. In this prospective study, 139 were recruited, 53 assigned group. relationships various metabolism-related biomarkers examined. These included serum (SI), total iron-binding capacity (TIBC), ferritin, transferrin, transferrin saturation. identify independent risk factors for SALI, both univariate multivariate logistic regression analyses performed. Additionally, receiver operating characteristic curve analysis was utilized assess predictive value these There no statistically significant differences in age, sex, body mass index, Sequential Organ Failure Assessment scores (excluding function), or APACHE II two groups patients. Compared sepsis group, group presented significantly higher SI (P < 0.001), TIBC ferritin = 0.005), saturation levels 0.001). Multivariate revealed (odds ratio 1.24, 95% confidence interval: 1.11-1.40, P 0.001) 1.13, 1.05-1.21, predictors Receiver had areas under 0.816 0.757, respectively, indicating moderate accuracy Iron disorders closely associated development may serve as potential biomarkers. combined use has superior diagnostic efficacy findings provide valuable insights management among sepsis.

Language: Английский

Luteolin modulates liver macrophage subtype polarization and play protective role in sepsis induced acute hepatic injury DOI

Liangyong Deng,

Qinwei Yu,

Gang Kuang

et al.

Inflammation Research, Journal Year: 2025, Volume and Issue: 74(1)

Published: March 28, 2025

Language: Английский

Citations

0
METTL3-mediated m6A modification in sepsis: current evidence and future perspectives DOI
Zijun Wu, Changhong Miao, Hao Zhang

et al.

Epigenomics, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: April 19, 2025

Sepsis, a severe systemic inflammatory condition triggered by infection, is associated with high morbidity and mortality worldwide. While medical diagnosis treatment have advanced in recent years, specific therapy remains unavailable. Recently, significant progress has been made studying the epigenetic RNA modification N6-methyladenosine (m6A) its core methyltransferase METTL3. The role of m6A sepsis also increasingly elucidated. This review aims to explore pathological mechanisms relationship m6A, focusing on key writer, METTL3, sepsis.

Language: Английский

Citations

0
CLICs Inhibitor IAA94 Alleviates Inflammation and Injury in Septic Liver by Preventing Pyroptosis in Macrophages DOI Creative Commons
Jing Liu, Jingwen Hu,

Xulei Yao

et al.

Inflammation, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Macrophage pyroptosis represents a pivotal mechanism underlying acute liver injury during sepsis. Chloride intracellular channel proteins (CLICs) have been linked to inflammatory reflexes, with IAA94 serving as an inhibitor of formation characteristic CLICs. In mouse model, demonstrated efficacy in reducing pro-inflammatory cytokines tissues, decreasing macrophage the liver, inhibiting development pro-fibrosis phenotype, and alleviating tissue injury. Additionally, exhibited inhibitory effects on activation NLRP3 inflammasome, leading suppression J774A.1 cells liver. was observed impede interaction between NEK7 NLRP3. Furthermore, it that conditioned medium pyroptotic macrophages treated induced attenuated response hepatocytes comparison by macrophages. However, overexpression impeded beneficial IAA94. conclusion, has capacity inflammasome formation-mediated blocking CLICs-mediated chloride efflux inhibition NEK7-NLRP3 interactions, thereby establishing CLICs promising therapeutic target against inflammation.

Language: Английский

Citations

0
Study of the relationship between iron metabolism disorders and sepsis-associated liver injury: A prospective observational study DOI
Tianwei Wang, Lulu Zhou, Jing Yuan

et al.

World Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 31(14)

Published: April 9, 2025

Sepsis-associated liver injury (SALI) refers to secondary function impairment caused by sepsis, patients with SALI often have worse clinical outcomes. The early identification and assessment of the occurrence progression are pressing issues that urgently need be resolved. To investigate relationship between iron metabolism SALI. In this prospective study, 139 were recruited, 53 assigned group. relationships various metabolism-related biomarkers examined. These included serum (SI), total iron-binding capacity (TIBC), ferritin, transferrin, transferrin saturation. identify independent risk factors for SALI, both univariate multivariate logistic regression analyses performed. Additionally, receiver operating characteristic curve analysis was utilized assess predictive value these There no statistically significant differences in age, sex, body mass index, Sequential Organ Failure Assessment scores (excluding function), or APACHE II two groups patients. Compared sepsis group, group presented significantly higher SI (P < 0.001), TIBC ferritin = 0.005), saturation levels 0.001). Multivariate revealed (odds ratio 1.24, 95% confidence interval: 1.11-1.40, P 0.001) 1.13, 1.05-1.21, predictors Receiver had areas under 0.816 0.757, respectively, indicating moderate accuracy Iron disorders closely associated development may serve as potential biomarkers. combined use has superior diagnostic efficacy findings provide valuable insights management among sepsis.

Language: Английский

Citations

0