Tactile suppression stems from specific sensorimotor predictions

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(20)

Published: May 9, 2022

Significance Tactile sensations on a moving hand are perceived weaker than when presented the same but stationary hand. There is an ongoing debate about whether this perception based sensorimotor predictions or due to blanket reduction in sensitivity. Here, we show greater suppression of matching predicted sensory feedback. This reinforces idea precise estimations future body states suppressing Our results shine light mechanisms human control and relevant for understanding clinical phenomena related predictive processes.

Language: Английский

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Neural Substrates of Body Ownership and Agency during Voluntary Movement

Journal of Neuroscience, Journal Year: 2023, Volume and Issue: 43(13), P. 2362 - 2380

Published: Feb. 17, 2023

Body ownership and the sense of agency are two central aspects bodily self-consciousness. While multiple neuroimaging studies have investigated neural correlates body separately, few relationship between these during voluntary movement when such experiences naturally combine. By eliciting moving rubber hand illusion with active or passive finger movements functional magnetic resonance imaging, we isolated activations reflecting agency, respectively, as well their interaction, assessed overlap anatomic segregation. We found that perceived was associated activity in premotor, posterior parietal, cerebellar regions, whereas over related to dorsal premotor cortex superior temporal cortex. Moreover, one section showed overlapping for somatosensory cortical reflected interaction higher both were experienced. further previously attributed left insular right temporoparietal junction synchrony asynchrony visuoproprioceptive stimuli rather than agency. Collectively, results reveal bases movement. Although representations largely distinct, there interactions neuroanatomical combination, which has bearing on theories SIGNIFICANCE STATEMENT How does brain generate being control (agency) parts belong one's (body ownership)? Using fMRI a triggered by movement, is cortex, regions. The sensations but an These findings advance our understanding interplay implications development advanced controllable prosthetic limbs feel like real limbs.

Language: Английский

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Dynamic changes in somatosensory and cerebellar activity mediate temporal recalibration of self-touch

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: May 3, 2024

Abstract An organism’s ability to accurately anticipate the sensations caused by its own actions is crucial for a wide range of behavioral, perceptual, and cognitive functions. Notably, sensorimotor expectations produced when touching one’s body attenuate such sensations, making them feel weaker less ticklish rendering easily distinguishable from potentially harmful touches external origin. How brain learns keeps these action-related sensory updated unclear. Here we employ psychophysics functional magnetic resonance imaging pinpoint behavioral neural substrates dynamic recalibration expected temporal delays in self-touch. Our psychophysical results reveal that self-touches are attenuated after systematic exposure delayed self-generated touches, while responses contralateral somatosensory cortex normally distinguish between nondelayed become indistinguishable. During exposure, ipsilateral anterior cerebellum shows increased activity, supporting proposed role recalibrating predictions. Moreover, cingulate areas gradually increase, suggesting as delay adaptation progresses, trigger activity related conflict. Together, our show predictions simplest act upheld sophisticated flexible mechanism maintains accurate time.

Language: Английский

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Cancelling cancellation? Sensorimotor control, agency, and prediction

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 145, P. 105012 - 105012

Published: Dec. 21, 2022

For decades, classic theories of action control and awareness have been built around the idea that brain predictively 'cancels' expected outcomes from perception. However, recent research casts doubt over this basic premise. What do these new findings mean for accounts action? Should we now 'cancel' old data, approaches generated under idea? In paper, argue 'No'. While doubts about predictive cancellation may urge us to fundamentally rethink how predictions shape perception, wider pyramid using ideas explain agentic experiences can remain largely intact. Some adaptive functions assigned be achieved through quasi-predictive processes, influence perception without actively tracking probabilistic structure environment. Other rely upon truly but not require cancel Appreciating role processes help move forward in explaining agents optimise their interactions with external world, even if is cancelled theory.

Language: Английский

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Action does not enhance but attenuates predicted touch

eLife, Journal Year: 2023, Volume and Issue: 12

Published: Dec. 15, 2023

Dominant motor control theories propose that the brain predicts and attenuates somatosensory consequences of actions, referred to as attenuation. Support comes from psychophysical neuroimaging studies showing touch applied on a passive hand elicits attenuated perceptual neural responses if it is actively generated by one's other hand, compared an identical external origin. However, recent experimental findings have challenged this view providing evidence perceived intensity enhanced active does not receive simultaneously with (somatosensory enhancement) further attributing attenuation double tactile stimulation hands upon contact. Here, we directly contrasted hypotheses enhancement models regarding how action influences perception manipulating whether contacts hand. We assessed in absence any predictive cues condition turned out be essential for interpreting findings. In three pre-registered experiments, demonstrate enhance predicted (Experiment 1), previously reported 'enhancement' effects are driven reference used 2), self-generated robustly regardless two make contact 3). Our results provide conclusive but prompt reappraisal which theoretical frameworks proposing prediction based.

Language: Английский

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The positive dimension of schizotypy is associated with a reduced attenuation and precision of self-generated touch

Schizophrenia, Journal Year: 2022, Volume and Issue: 8(1)

Published: June 29, 2022

The brain predicts the sensory consequences of our movements and uses these predictions to attenuate perception self-generated sensations. Accordingly, touch feels weaker than an externally generated identical intensity. In schizophrenia, this somatosensory attenuation is substantially reduced, suggesting that patients with positive symptoms fail accurately predict process touch. If impaired prediction underlies then a similar impairment should exist in healthy nonclinical individuals high schizotypal traits. One hundred participants (53 female), assessed for traits, underwent well-established psychophysics force discrimination task quantify how they perceived intensity tactile stimuli delivered their left index finger (magnitude) ability discriminate (precision) was measured. We observed higher traits were associated reduced poorer precision touch, both when treating schizotypy as continuous or categorical variable. These effects specific not negative disorganized dimensions schizotypy. results suggest are Given dimension represents analogue psychotic deficits processing information could indicate increased liability schizophrenia.

Language: Английский

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Emergence of sensory attenuation based upon the free-energy principle

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Aug. 25, 2022

Abstract The brain attenuates its responses to self-produced exteroceptions (e.g., we cannot tickle ourselves). Is this phenomenon, known as sensory attenuation, enabled innately, or acquired through learning? Here, our simulation study using a multimodal hierarchical recurrent neural network model, based on variational free-energy minimization, shows that mechanism for attenuation can develop learning of two distinct types sensorimotor experience, involving externally produced exteroceptions. For each context, particular state emerged interaction between top-down prediction with precision and bottom-up error from area. executive area in the served an information hub. Consequently, shifts contexts triggered transitions one another via control, which caused attenuating amplifying prediction-error-induced areas. This situates emergence (or self-other distinction) development states dynamic system.

Language: Английский

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Brief Temporal Perturbations in Somatosensory Reafference Disrupt Perceptual and Neural Attenuation and Increase Supplementary Motor Area–Cerebellar Connectivity

Journal of Neuroscience, Journal Year: 2023, Volume and Issue: 43(28), P. 5251 - 5263

Published: June 20, 2023

Intrinsic delays in sensory feedback can be detrimental for motor control. As a compensation strategy, the brain predicts consequences of movement via forward model on basis copy command. Using these predictions, attenuates somatosensory reafference to facilitate processing exafferent information. Theoretically, this predictive attenuation is disrupted by (even minimal) temporal errors between predicted and actual reafference; however, direct evidence such disruption lacking as previous neuroimaging studies contrasted nondelayed reafferent input with input. Here, we combined psychophysics functional magnetic resonance imaging test whether subtle perturbations timing disrupt its processing. Twenty-eight participants (14 women) generated touches their left index finger tapping sensor right finger. The were delivered close time contact two fingers or perturbation (i.e., 153 ms delay). We found that brief at both perceptual neural levels, leading greater cerebellar responses weaker connectivity cerebellum, proportional changes. interpret effects failure predictively attenuate perturbed reafference. Moreover, observed increased supplementary area cerebellum during perturbations, which could indicate communication prediction error back centers. SIGNIFICANCE STATEMENT Our receives from our movements delay. To counteract delays, control theories postulate sensations received time. Thus, self-generated touch feels than an identical external touch. However, how perturb remains unknown. show make otherwise attenuated feel stronger, elicit stronger responses, weaken areas, increase areas. These findings areas are fundamental forming predictions about movements.

Language: Английский

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Cerebellar Purkinje cells combine sensory and motor information to predict the sensory consequences of active self-motion in macaques

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 11, 2024

Abstract Accurate perception and behavior rely on distinguishing sensory signals arising from unexpected events those originating our own voluntary actions. In the vestibular system, input that is consequence of active self-motion canceled early at first central stage processing to ensure postural perceptual stability. However, source required cancellation signal was unknown. Here, we show cerebellum combines motor-related information predict consequences self-motion. Recordings during attempted but unrealized head movements in two male rhesus monkeys, revealed encoded by anterior vermis Purkinje cells explain their altered sensitivity versus passive Further, a model combining responses ~40 accounted for observed pathways. These findings establish how cerebellar outcomes self-movements, resolving long-standing issue suppression

Language: Английский

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Distinct role of central predictive mechanisms in tactile suppression

iScience, Journal Year: 2024, Volume and Issue: 27(8), P. 110582 - 110582

Published: July 25, 2024

Language: Английский

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