Nano Express,
Journal Year:
2024,
Volume and Issue:
5(4), P. 045009 - 045009
Published: Nov. 14, 2024
Abstract
Microbial
diseases
represent
a
significant
challenge
to
global
health,
highlighting
the
importance
of
developing
novel
alternative
antibacterial
agents.
The
widely
used
spice
and
traditional
medicinal
plant
Zingiber
officinale
its
derivatives
have
been
demonstrated
possess
promising
properties.
aim
present
study
was
assess
efficacy
-derived
exosome-like
nanoparticles
(ZODENs)
against
model
bacterium,
Escherichia
coli
(
E.
).
ZODENs
were
isolated
from
rhizome
subjected
morphological,
size
distribution,
zeta
potential
characterization.
bacterial
growth
curve
assays
colony
formation
that
remarkably
inhibited
following
incubation
with
ZODENs.
observed
be
internalized
by
bacteria
incubation,
subsequently
remarkable
killing
effects.
Furthermore,
ZODEN-derived
lipids,
rather
than
remaining
fractions,
capacity
inhibit
cells,
indicating
activity
at
least
partially
attributable
lipid
content.
These
findings
paved
way
for
development
ZODEN-based
agents
will
facilitate
future
clinical
translation
plant-derived
nanomedicines.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 6161 - 6176
Published: June 1, 2024
Abstract:
Idiopathic
pulmonary
fibrosis
(IPF)
poses
a
formidable
clinical
challenge,
characterized
by
the
thickening
of
alveolar
septa
and
onset
fibrosis.
The
pronounced
activation
oxidative
stress
emerges
as
pivotal
hallmark
inflammation.
Traditional
application
exogenous
antioxidants
proves
inadequate
in
addressing
stress,
necessitating
exploration
into
strategies
to
augment
their
antioxidant
efficacy.
Exosomes,
nano-sized
extracellular
vesicles
harboring
diverse
array
bioactive
factors,
present
promising
carriers
with
potential
meet
this
challenge.
Recent
attention
has
been
directed
towards
applications
exosomes
IPF,
fueling
impetus
for
comprehensive
review.
We
have
compiled
fresh
insights
role
modulating
IPF
delved
regulating
endogenous
reactive
oxygen
species
generation.
This
review
endeavors
bridge
divide
between
exosome
research
traversing
from
bedside
bench.
Through
synthesis
recent
findings,
we
propose
novel
strategy
improving
outcomes
therapy.
Keywords:
idiopathic
fibrosis,
exosomes,
treatment
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: Sept. 9, 2024
With
outstanding
therapeutic
potential
in
the
tissue
regeneration
and
anti-inflammation,
mesenchymal
stem
cell-derived
exosomes
(MSC-EXOs)
have
emerged
as
a
prominent
recent.
However,
poor
production
yield
reproducibility
remained
significant
challenges
of
their
practical
applications.
To
surmount
these
challenges,
various
alternative
materials
with
cell-like
functions,
been
recently
investigated,
however,
there
has
no
comprehensive
analysis
alternatives
so
far.
Here,
we
discuss
recent
progress
MSC-EXOs,
including
exosome-like
nanovesicles
from
biological
sources
such
plants,
milk,
microbes,
body
fluids.
Moreover,
extensively
compare
each
by
summarizing
unique
functions
mode
actions
to
suggest
expected
target
future
directions
for
developing
MSC-EXOs.
Nano Express,
Journal Year:
2024,
Volume and Issue:
5(4), P. 045009 - 045009
Published: Nov. 14, 2024
Abstract
Microbial
diseases
represent
a
significant
challenge
to
global
health,
highlighting
the
importance
of
developing
novel
alternative
antibacterial
agents.
The
widely
used
spice
and
traditional
medicinal
plant
Zingiber
officinale
its
derivatives
have
been
demonstrated
possess
promising
properties.
aim
present
study
was
assess
efficacy
-derived
exosome-like
nanoparticles
(ZODENs)
against
model
bacterium,
Escherichia
coli
(
E.
).
ZODENs
were
isolated
from
rhizome
subjected
morphological,
size
distribution,
zeta
potential
characterization.
bacterial
growth
curve
assays
colony
formation
that
remarkably
inhibited
following
incubation
with
ZODENs.
observed
be
internalized
by
bacteria
incubation,
subsequently
remarkable
killing
effects.
Furthermore,
ZODEN-derived
lipids,
rather
than
remaining
fractions,
capacity
inhibit
cells,
indicating
activity
at
least
partially
attributable
lipid
content.
These
findings
paved
way
for
development
ZODEN-based
agents
will
facilitate
future
clinical
translation
plant-derived
nanomedicines.
