Small Intestinal Slow Wave Dysrhythmia and Blunted Postprandial Responses in Diabetic Rats

Neurogastroenterology & Motility, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Gastric dysmotility and gastric slow wave dysrhythmias have been well documented in patients with diabetes. However, little is known on the effect of hyperglycemia small intestine motility, such as intestinal waves, due to limited options measuring its activity. Moreover, food intake digestion process reported alter motility normal rats, but their roles that diabetic rats remains unknown. This study aimed explore myoelectrical activity (IMA) responses various meals rats. IMA was recorded via chronically implanted serosal electrodes proximal type 2 diabetes induced by high-fat diet feeding followed a low dose streptozotocin (30 mg/kg) The percentage (%NSW), dominant power, frequency (DF) were assessed from under conditions. Oral glucose tolerance test performed, blood collected tail vein at baseline 15, 30, 60, 90, 120, 180 min after administration for measurement glucose. Regular laboratory chow, diet, or large nutrient liquid meal used different (1) Compared postprandial increase DF (p = 0.007), showed blunted response 0.145) regular chow. no difference found %NSW between both fasting fed states; (2) In state, correlated level (r -0.817, p 0.004, N 8) HbA1C -0.871, 0.005, 8). After administration, decrease -0.655, < 0.001, (3) during 30-min state not altered meal, either solid, suggesting an absence gastric-small reflex. regularity waves negatively states. Diabetic exhibit compared There seems be lack reflex upon ingestion

Language: Английский

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Vagal nerve stimulation dynamically alters anxiety-like behavior in rats.

Brain stimulation, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Genetic labeling of the nucleus of tractus solitarius neurons associated with electrical stimulation of the cervical or auricular vagus nerve in mice

Brain stimulation, Journal Year: 2024, Volume and Issue: 17(5), P. 987 - 1000

Published: Aug. 23, 2024

Vagus nerve stimulation (VNS) is clinically useful for treating epilepsy, depression, and chronic pain. Currently, cervical VNS (cVNS) treatment well-established, while auricular (aVNS) under development. Vagal regulates functions in diverse brain regions; therefore, it critical to better understand how electrically-evoked vagal inputs following cVNS aVNS engage with different regions.

Language: Английский

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Hindbrain Networks: Exploring the Hidden Anxiety Circuits in Rodents

Behavioural Brain Research, Journal Year: 2024, Volume and Issue: 476, P. 115281 - 115281

Published: Oct. 5, 2024

Language: Английский

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