Rat Models in Post-Traumatic Stress Disorder Research: Strengths, Limitations, and Implications for Translational Studies DOI Creative Commons
Alexey Sarapultsev, Maria Komelkova, Oleg Lookin

et al.

Pathophysiology, Journal Year: 2024, Volume and Issue: 31(4), P. 709 - 760

Published: Dec. 6, 2024

Post-Traumatic Stress Disorder (PTSD) is a multifaceted psychiatric disorder triggered by traumatic events, leading to prolonged psychological distress and varied symptoms. Rat models have been extensively used explore the biological, behavioral, neurochemical underpinnings of PTSD. This review critically examines strengths limitations commonly rat models, such as single stress (SPS), stress–re-stress (S-R), predator-based paradigms, in replicating human PTSD pathology. While these provide valuable insights into neuroendocrine responses, genetic predispositions, potential therapeutic targets, they face challenges capturing full complexity PTSD, particularly terms ethological relevance translational validity. We assess degree which mimic neurobiological behavioral aspects highlighting areas where succeed fall short. also discusses future directions refining improve their utility for research, aiming bridge gap between preclinical findings clinical applications.

Language: Английский

Rat Models in Post-Traumatic Stress Disorder Research: Strengths, Limitations, and Implications for Translational Studies DOI Creative Commons
Alexey Sarapultsev, Maria Komelkova, Oleg Lookin

et al.

Pathophysiology, Journal Year: 2024, Volume and Issue: 31(4), P. 709 - 760

Published: Dec. 6, 2024

Post-Traumatic Stress Disorder (PTSD) is a multifaceted psychiatric disorder triggered by traumatic events, leading to prolonged psychological distress and varied symptoms. Rat models have been extensively used explore the biological, behavioral, neurochemical underpinnings of PTSD. This review critically examines strengths limitations commonly rat models, such as single stress (SPS), stress–re-stress (S-R), predator-based paradigms, in replicating human PTSD pathology. While these provide valuable insights into neuroendocrine responses, genetic predispositions, potential therapeutic targets, they face challenges capturing full complexity PTSD, particularly terms ethological relevance translational validity. We assess degree which mimic neurobiological behavioral aspects highlighting areas where succeed fall short. also discusses future directions refining improve their utility for research, aiming bridge gap between preclinical findings clinical applications.

Language: Английский

Citations

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