Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Dec. 13, 2022
Abundant
heterogeneous
immune
cells
infiltrate
lesions
in
chronic
inflammatory
diseases
and
characterization
of
these
is
needed
to
distinguish
disease-promoting
from
bystander
cells.
Here,
we
investigate
the
landscape
non-communicable
skin
(ncISD)
by
spatial
transcriptomics
resulting
a
large
repository
62,000
spatially
defined
human
cutaneous
transcriptomes
31
patients.
Despite
expected
cell
infiltration,
observe
rather
low
numbers
pathogenic
disease
promoting
cytokine
transcripts
(IFNG,
IL13
IL17A),
i.e.
>125
times
less
compared
mean
expression
all
other
genes
over
lesional
sections.
Nevertheless,
limited
presented
disease-specific
pattern.
Leveraging
density-based
clustering
method,
identify
specific
responder
gene
signatures
direct
proximity
cytokines,
confirm
that
detected
initiate
amplification
cascades
up
thousands
forming
localized
epidermal
clusters.
Thus,
within
abundant
infiltrates
ncISD,
only
number
their
translated
proteins
promote
initiating
an
cascade
local
microenvironment.
Cells,
Journal Year:
2020,
Volume and Issue:
9(5), P. 1157 - 1157
Published: May 7, 2020
Exosomes
are
nano-sized
vesicles
that
serve
as
mediators
for
cell-to-cell
communication.
With
their
unique
nucleic
acids,
proteins,
and
lipids
cargo
compositions
reflect
the
characteristics
of
producer
cells,
exosomes
can
be
utilized
cell-free
therapeutics.
Among
derived
from
various
cellular
origins,
mesenchymal
stem
cell-derived
(MSC-exosomes)
have
gained
great
attention
due
to
immunomodulatory
regenerative
functions.
Indeed,
many
studies
shown
anti-inflammatory,
anti-aging
wound
healing
effects
MSC-exosomes
in
vitro
vivo
models.
In
addition,
recent
advances
field
exosome
biology
enabled
development
specific
guidelines
quality
control
methods,
which
will
ultimately
lead
clinical
application
exosomes.
This
review
highlights
investigate
therapeutic
potential
relevant
mode
actions
skin
diseases,
well
measures
required
exosome-derived
Advanced Materials,
Journal Year:
2020,
Volume and Issue:
32(33)
Published: June 29, 2020
Abstract
Skin
infections
caused
by
bacteria,
viruses
and
fungi
are
difficult
to
treat
conventional
topical
administration
because
of
poor
drug
penetration
across
the
stratum
corneum.
This
results
in
low
bioavailability
drugs
infection
site,
as
well
lack
prolonged
release.
Emerging
antimicrobial
transdermal
ocular
microneedle
patches
have
become
promising
medical
devices
for
delivery
various
antibacterial,
antifungal,
antiviral
therapeutics.
In
present
review,
skin
anatomy
its
barriers
along
with
discussed.
Potential
strategies
designing
microneedles
their
targeted
therapy
outlined.
Finally,
biosensing
associated
personalized
selective
toxicity
toward
specific
microbial
species
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(22), P. 8790 - 8790
Published: Nov. 20, 2020
As
the
most
dominant
cell
type
in
skin,
keratinocytes
play
critical
roles
wound
repair
not
only
as
structural
cells
but
also
exerting
important
immune
functions.
This
review
focuses
on
communications
between
and
healing,
which
are
mediated
by
various
cytokines,
chemokines,
extracellular
vesicles.
Keratinocytes
can
directly
interact
with
T
via
antigen
presentation.
Moreover,
produce
antimicrobial
peptides
that
kill
invading
pathogens
contribute
to
many
aspects.
We
reviewed
epigenetic
mechanisms
known
regulate
keratinocyte
functions,
including
histone
modifications,
non-protein-coding
RNAs
(e.g.,
microRNAs,
long
noncoding
RNAs),
chromatin
dynamics.
Lastly,
we
summarized
current
evidence
dysregulated
functions
of
chronic
nonhealing
wounds.
Based
their
crucial
skin
propose
significantly
pathogenesis
inflammation.
hope
this
will
trigger
an
interest
investigating
pathology,
may
open
up
new
avenues
for
developing
innovative
treatments.
Cosmetics,
Journal Year:
2021,
Volume and Issue:
8(3), P. 69 - 69
Published: Aug. 4, 2021
Acidic
pH
of
the
skin
surface
has
been
recognized
as
a
regulating
factor
for
maintenance
stratum
corneum
homeostasis
and
barrier
permeability.
The
most
important
functions
acidic
seem
to
be
related
keratinocyte
differentiation
process,
formation
function
epidermal
lipids
corneocyte
lipid
envelope,
microbiome
and,
consequently,
disturbances
diseases.
As
acknowledged
extrinsic
factors
that
affect
pH,
topically
applied
products
could
contribute
health
via
value
control.
obtained
knowledge
on
skins’
used
in
formulation
more
effective
topical
products,
which
would
add
development
so-called
‘for
maintenance’.
There
is
high
level
agreement
should
acidified
possess
range
4
6.
However,
formulators,
dermatologists
consumers
benefit
from
some
precise
guidance
concerning
favorable
values
selection
cosmetic
ingredients
responsible
acidification,
together
with
extensive
understanding
mechanisms
underlaying
process
acidification
by
products.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(4), P. 3950 - 3950
Published: Feb. 16, 2023
Our
skin
is
the
largest
organ
of
body,
serving
as
an
important
barrier
against
harsh
extrinsic
environment.
Alongside
preventing
desiccation,
chemical
damage
and
hypothermia,
this
protects
body
from
invading
pathogens
through
a
sophisticated
innate
immune
response
co-adapted
consortium
commensal
microorganisms,
collectively
termed
microbiota.
These
microorganisms
inhabit
distinct
biogeographical
regions
dictated
by
physiology.
Thus,
it
follows
that
perturbations
to
normal
homeostasis,
occurs
with
ageing,
diabetes
disease,
can
cause
microbial
dysbiosis
increase
infection
risk.
In
review,
we
discuss
emerging
concepts
in
microbiome
research,
highlighting
pertinent
links
between
cutaneous
repair.
Moreover,
address
gaps
current
knowledge
highlight
key
areas
requiring
further
exploration.
Future
advances
field
could
revolutionise
way
treat
associated
ageing
other
pathologies.
Human
skin
is
home
to
a
variety
of
commensal
bacteria,
including
many
species
coagulase-negative
staphylococci
(CoNS).
While
it
well
established
that
the
microbiota
as
whole
maintains
homeostasis
and
excludes
pathogens
(i.e.,
colonization
resistance),
relatively
little
known
about
unique
contributions
individual
CoNS
these
interactions.
Staphylococcus
hominis
second
most
frequently
isolated
from
healthy
skin,
there
emerging
evidence
suggest
may
play
an
important
role
in
excluding
pathogens,
aureus
,
colonizing
or
infecting
skin.
Cells,
Journal Year:
2023,
Volume and Issue:
12(23), P. 2745 - 2745
Published: Nov. 30, 2023
An
intact
barrier
function
of
the
skin
is
important
in
maintaining
health.
The
regulation
depends
on
a
multitude
molecular
and
immunological
signaling
pathways.
By
examining
healthy
barrier,
including
maintenance
acid
mantle
appropriate
levels
ceramides,
dermatologists
can
better
formulate
solutions
to
address
issues
that
are
related
disrupted
barrier.
Conversely,
by
understanding
specific
disruptions
associated
with
conditions,
such
as
atopic
dermatitis
or
psoriasis,
development
new
compounds
could
target
pathways
provide
more
effective
relief
for
patients.
We
aim
review
key
factors
mediating
inflammation,
acidity,
interleukins,
nuclear
factor
kappa
B,
sirtuin
3.
Furthermore,
we
will
discuss
current
emerging
treatment
options
conditions.
Journal of Cosmetic Dermatology,
Journal Year:
2024,
Volume and Issue:
23(5), P. 1518 - 1526
Published: Feb. 26, 2024
Abstract
Background
The
skin
is
the
largest
organ
in
human
body,
not
only
resisting
invasion
of
harmful
substances,
but
also
preventing
loss
moisture
and
nutrients.
Maintaining
homeostasis
a
prerequisite
for
proper
functioning
body.
Any
damage
to
can
lead
decrease
local
homeostasis,
such
as
ultraviolet
radiation,
seasonal
changes,
air
pollution,
which
tissue
affect
function
barrier.
Objective
This
article
reviews
maintenance
mechanism
influencing
factors
symptoms
imbalance.
Methods
We
searched
articles
published
between
1990
2022
English
Chinese
using
PubMed,
Web
Science,
CNKI,
other
databases
subject
area
dermatology,
following
search
terms
various
combinations:
“skin
homeostasis,”
barrier,”
“unstable
skin.”
Based
on
our
results,
we
further
refined
criteria
include
series
common
problems
caused
by
destruction
its
treatments.
Limitations
lack
research
dermatological
cosmetic
triggered
disruption
homeostasis.
Results
study
describes
neuroendocrine‐immune
system,
barrier
structure,
metabolic
system
that
maintain
In
addition,
discuss
several
occur
when
out
balance,
dryness,
redness,
acne,
sensitivity,
aging,
explain
these
symptoms.
Conclusion
provides
an
update
review
students
practitioners,
theoretical
basis
development
care
products
repair
